Staphylococcus aureus Transcriptome Data and Metabolic Modelling Investigate the Interplay of Ser/Thr Kinase PknB, Its Phosphatase Stp, the glmR/yvcK Regulon and the cdaA Operon for Metabolic Adaptation Article Swipe
Chunguang Liang
,
Ana B. Rios‐Miguel
,
Marcel Jarick
,
Priya Neurgaonkar
,
Myriam Girard
,
Patrice François
,
Jacques Schrenzel
,
Eslam S. Ibrahim
,
Knut Ohlsen
,
Thomas Dandekar
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/microorganisms9102148
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/microorganisms9102148
Serine/threonine kinase PknB and its corresponding phosphatase Stp are important regulators of many cell functions in the pathogen S. aureus. Genome-scale gene expression data of S. aureus strain NewHG (sigB+) elucidated their effect on physiological functions. Moreover, metabolic modelling from these data inferred metabolic adaptations. We compared wild-type to deletion strains lacking pknB, stp or both. Ser/Thr phosphorylation of target proteins by PknB switched amino acid catabolism off and gluconeogenesis on to provide the cell with sufficient components. We revealed a significant impact of PknB and Stp on peptidoglycan, nucleotide and aromatic amino acid synthesis, as well as catabolism involving aspartate transaminase. Moreover, pyrimidine synthesis was dramatically impaired by stp deletion but only slightly by functional loss of PknB. In double knockouts, higher activity concerned genes involved in peptidoglycan, purine and aromatic amino acid synthesis from glucose but lower activity of pyrimidine synthesis from glucose compared to the wild type. A second transcriptome dataset from S. aureus NCTC 8325 (sigB−) validated the predictions. For this metabolic adaptation, PknB was found to interact with CdaA and the yvcK/glmR regulon. The involved GlmR structure and the GlmS riboswitch were modelled. Furthermore, PknB phosphorylation lowered the expression of many virulence factors, and the study shed light on S. aureus infection processes.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/microorganisms9102148
- https://www.mdpi.com/2076-2607/9/10/2148/pdf?version=1634292897
- OA Status
- gold
- Cited By
- 10
- References
- 54
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3207666385
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- OpenAlex ID
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https://openalex.org/W3207666385Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/microorganisms9102148Digital Object Identifier
- Title
-
Staphylococcus aureus Transcriptome Data and Metabolic Modelling Investigate the Interplay of Ser/Thr Kinase PknB, Its Phosphatase Stp, the glmR/yvcK Regulon and the cdaA Operon for Metabolic AdaptationWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-10-14Full publication date if available
- Authors
-
Chunguang Liang, Ana B. Rios‐Miguel, Marcel Jarick, Priya Neurgaonkar, Myriam Girard, Patrice François, Jacques Schrenzel, Eslam S. Ibrahim, Knut Ohlsen, Thomas DandekarList of authors in order
- Landing page
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https://doi.org/10.3390/microorganisms9102148Publisher landing page
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https://www.mdpi.com/2076-2607/9/10/2148/pdf?version=1634292897Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
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https://www.mdpi.com/2076-2607/9/10/2148/pdf?version=1634292897Direct OA link when available
- Concepts
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Regulon, Staphylococcus aureus, Operon, Transcriptome, Metabolic activity, Adaptation (eye), Biology, Phosphatase, Microbiology, Enzyme, Biochemistry, Genetics, Biological system, Bacterial protein, Neuroscience, Bacteria, Gene, Gene expression, Escherichia coliTop concepts (fields/topics) attached by OpenAlex
- Cited by
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10Total citation count in OpenAlex
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2025: 4, 2024: 1, 2023: 4, 2022: 1Per-year citation counts (last 5 years)
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54Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.from | 39, 135, 143, 154 |
| abstract_inverted_index.gene | 21 |
| abstract_inverted_index.loss | 116 |
| abstract_inverted_index.many | 12, 195 |
| abstract_inverted_index.only | 112 |
| abstract_inverted_index.shed | 201 |
| abstract_inverted_index.this | 164 |
| abstract_inverted_index.well | 96 |
| abstract_inverted_index.were | 186 |
| abstract_inverted_index.wild | 148 |
| abstract_inverted_index.with | 75, 172 |
| abstract_inverted_index.NewHG | 28 |
| abstract_inverted_index.PknB. | 118 |
| abstract_inverted_index.amino | 64, 92, 132 |
| abstract_inverted_index.both. | 55 |
| abstract_inverted_index.found | 169 |
| abstract_inverted_index.genes | 125 |
| abstract_inverted_index.light | 202 |
| abstract_inverted_index.lower | 138 |
| abstract_inverted_index.pknB, | 52 |
| abstract_inverted_index.study | 200 |
| abstract_inverted_index.their | 31 |
| abstract_inverted_index.these | 40 |
| abstract_inverted_index.type. | 149 |
| abstract_inverted_index.aureus | 26, 156, 205 |
| abstract_inverted_index.double | 120 |
| abstract_inverted_index.effect | 32 |
| abstract_inverted_index.higher | 122 |
| abstract_inverted_index.impact | 82 |
| abstract_inverted_index.kinase | 1 |
| abstract_inverted_index.purine | 129 |
| abstract_inverted_index.second | 151 |
| abstract_inverted_index.strain | 27 |
| abstract_inverted_index.target | 59 |
| abstract_inverted_index.(sigB+) | 29 |
| abstract_inverted_index.Ser/Thr | 56 |
| abstract_inverted_index.aureus. | 19 |
| abstract_inverted_index.dataset | 153 |
| abstract_inverted_index.glucose | 136, 144 |
| abstract_inverted_index.lacking | 51 |
| abstract_inverted_index.lowered | 191 |
| abstract_inverted_index.provide | 72 |
| abstract_inverted_index.strains | 50 |
| abstract_inverted_index.activity | 123, 139 |
| abstract_inverted_index.aromatic | 91, 131 |
| abstract_inverted_index.compared | 46, 145 |
| abstract_inverted_index.deletion | 49, 110 |
| abstract_inverted_index.factors, | 197 |
| abstract_inverted_index.impaired | 107 |
| abstract_inverted_index.inferred | 42 |
| abstract_inverted_index.interact | 171 |
| abstract_inverted_index.involved | 126, 179 |
| abstract_inverted_index.pathogen | 17 |
| abstract_inverted_index.proteins | 60 |
| abstract_inverted_index.regulon. | 177 |
| abstract_inverted_index.revealed | 79 |
| abstract_inverted_index.slightly | 113 |
| abstract_inverted_index.switched | 63 |
| abstract_inverted_index.(sigB−) | 159 |
| abstract_inverted_index.Moreover, | 36, 102 |
| abstract_inverted_index.aspartate | 100 |
| abstract_inverted_index.concerned | 124 |
| abstract_inverted_index.functions | 14 |
| abstract_inverted_index.important | 9 |
| abstract_inverted_index.infection | 206 |
| abstract_inverted_index.involving | 99 |
| abstract_inverted_index.metabolic | 37, 43, 165 |
| abstract_inverted_index.modelled. | 187 |
| abstract_inverted_index.modelling | 38 |
| abstract_inverted_index.structure | 181 |
| abstract_inverted_index.synthesis | 104, 134, 142 |
| abstract_inverted_index.validated | 160 |
| abstract_inverted_index.virulence | 196 |
| abstract_inverted_index.wild-type | 47 |
| abstract_inverted_index.yvcK/glmR | 176 |
| abstract_inverted_index.catabolism | 66, 98 |
| abstract_inverted_index.elucidated | 30 |
| abstract_inverted_index.expression | 22, 193 |
| abstract_inverted_index.functional | 115 |
| abstract_inverted_index.functions. | 35 |
| abstract_inverted_index.knockouts, | 121 |
| abstract_inverted_index.nucleotide | 89 |
| abstract_inverted_index.processes. | 207 |
| abstract_inverted_index.pyrimidine | 103, 141 |
| abstract_inverted_index.regulators | 10 |
| abstract_inverted_index.riboswitch | 185 |
| abstract_inverted_index.sufficient | 76 |
| abstract_inverted_index.synthesis, | 94 |
| abstract_inverted_index.adaptation, | 166 |
| abstract_inverted_index.components. | 77 |
| abstract_inverted_index.phosphatase | 6 |
| abstract_inverted_index.significant | 81 |
| abstract_inverted_index.Furthermore, | 188 |
| abstract_inverted_index.Genome-scale | 20 |
| abstract_inverted_index.adaptations. | 44 |
| abstract_inverted_index.dramatically | 106 |
| abstract_inverted_index.predictions. | 162 |
| abstract_inverted_index.corresponding | 5 |
| abstract_inverted_index.physiological | 34 |
| abstract_inverted_index.transaminase. | 101 |
| abstract_inverted_index.transcriptome | 152 |
| abstract_inverted_index.peptidoglycan, | 88, 128 |
| abstract_inverted_index.gluconeogenesis | 69 |
| abstract_inverted_index.phosphorylation | 57, 190 |
| abstract_inverted_index.Serine/threonine | 0 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5086202312, https://openalex.org/A5107393601 |
| countries_distinct_count | 4 |
| institutions_distinct_count | 10 |
| corresponding_institution_ids | https://openalex.org/I25974101 |
| citation_normalized_percentile.value | 0.64223858 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |