State of the art of the molecular hyperselection to guide treatment with anti-EGFR antibodies in RAS WT mCRC: implications for clinical practice and future perspectives Article Swipe
Pilar García‐Alfonso
,
Manuel Valladares‐Ayerbes
,
Andrés J. Muñoz Martín
,
Rocío Morales Herrero
,
Eva Muñoz
,
Gerard Prat-Llorens
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1080/14712598.2025.2477192
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1080/14712598.2025.2477192
Negative hyperselection beyond RAS and BRAF in advanced colorectal cancer appears to be a powerful tool for predicting outcomes to anti-EGFR therapy and spare patients from unnecessary treatment. This improvement appears in both naïve and pre-treated patients. However, data come mainly from retrospective studies. Therefore, to validate and integrate these findings in the clinical practice, prospective studies should be conducted. It will be interesting to elucidate the role of ctDNA in this setting and the choice of molecular techniques, considering costs and accessibility, to guarantee its implementation in the clinic.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1080/14712598.2025.2477192
- https://www.tandfonline.com/doi/pdf/10.1080/14712598.2025.2477192?needAccess=true
- OA Status
- bronze
- Cited By
- 1
- References
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- Related Works
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4408341556Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1080/14712598.2025.2477192Digital Object Identifier
- Title
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State of the art of the molecular hyperselection to guide treatment with anti-EGFR antibodies in RAS WT mCRC: implications for clinical practice and future perspectivesWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-03-11Full publication date if available
- Authors
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Pilar García‐Alfonso, Manuel Valladares‐Ayerbes, Andrés J. Muñoz Martín, Rocío Morales Herrero, Eva Muñoz, Gerard Prat-LlorensList of authors in order
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https://doi.org/10.1080/14712598.2025.2477192Publisher landing page
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https://www.tandfonline.com/doi/pdf/10.1080/14712598.2025.2477192?needAccess=trueDirect link to full text PDF
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YesWhether a free full text is available
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bronzeOpen access status per OpenAlex
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https://www.tandfonline.com/doi/pdf/10.1080/14712598.2025.2477192?needAccess=trueDirect OA link when available
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Antibody, Clinical Practice, Medicine, Cancer research, Immunology, Family medicineTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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