Statin Therapy and its Impact on Cognitive Functions in Elderly Patients: A Current Systematic Review Article Swipe

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Kemar Anthony Samuels , Antonia Lisseth Valle Villatoro , Sumera Afzal , Farzana Rahman , Benish Alam , Atif Rashid , Ifeoluwa Fadeyibi , Ngozi Amanze , Tambi Isaac , Jashanpreet Singh Ballagan , S. F. Lawal , Agho Osamede , Ghulam Muhammad Humayun , Olusayo Louise-Oluwasanmi , Omolola Okunromade ·

YOU? · · 2023 · Open Access · · DOI: https://doi.org/10.9734/jammr/2023/v35i215224

Introduction: Statin therapy is a well-established treatment for cardiovascular disease, with potential implications for cognitive function. However, reports have been inconsistent regarding statin therapy's impact on cognitive function in elderly patients. This systematic review aimed to evaluate the current evidence relating to the cognitive effects of statin therapy in the elderly population. Methods: A comprehensive literature search was conducted using the databases PubMed, Embase, and Cochrane Library, up to May 2023. Eligibility criteria included randomized controlled trials and observational studies involving elderly patients on statin therapy, with a focus on cognitive function outcomes. Studies were excluded if they did not provide comparative data for elderly patients not on statin therapy. Results: Out of fourteen studies, representing a diverse population of 68,724 participants, the majority suggested a neutral or beneficial impact of statin use on cognitive function in the elderly population. For instance, a large-scale study involving patients with cardiovascular disease demonstrated no adverse cognitive effects following statin therapy. Another study involving hypertensive elderly patients indicated a possible protective role of statins against cognitive impairment. On the whole, the results were heterogenous, with no substantial evidence pointing towards a harmful effect of statins on cognitive health. Conclusion: The review provides evidence that statin therapy does not appear to negatively impact cognitive functions in elderly patients. Rather, the findings lean toward a neutral or potentially protective effect. Considering the global prevalence of statin use, these findings should reassure clinicians and patients about the cognitive safety of these medications. However, given the importance of this issue, further large-scale studies are recommended to confirm these findings and further elucidate any potential cognitive benefits associated with statin therapy.

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Randomized Controlled Trial

Concepts

Medicine Statin Cognition Observational study Population Physical therapy Cochrane Library Adverse effect Randomized controlled trial Cognitive decline Disease Intensive care medicine Dementia Internal medicine Psychiatry Environmental health

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Type: article
Language: en
Landing Page: https://doi.org/10.9734/jammr/2023/v35i215224
PDF: https://journaljammr.com/index.php/JAMMR/article/view/5224/10418
OA Status: diamond
Cited By: 1
References: 22
Related Works: 10
OpenAlex ID: https://openalex.org/W4386829875

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DOI: https://doi.org/10.9734/jammr/2023/v35i215224

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Title: Statin Therapy and its Impact on Cognitive Functions in Elderly Patients: A Current Systematic Review

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Language: en

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Publication year: 2023

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Publication date: 2023-09-18

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Authors: Kemar Anthony Samuels, Antonia Lisseth Valle Villatoro, Sumera Afzal, Farzana Rahman, Benish Alam, Atif Rashid, Ifeoluwa Fadeyibi, Ngozi Amanze, Tambi Isaac, Jashanpreet Singh Ballagan, S. F. Lawal, Agho Osamede, Ghulam Muhammad Humayun, Olusayo Louise-Oluwasanmi, Omolola Okunromade

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Landing page: https://doi.org/10.9734/jammr/2023/v35i215224

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Concepts: Medicine, Statin, Cognition, Observational study, Population, Physical therapy, Cochrane Library, Adverse effect, Randomized controlled trial, Cognitive decline, Disease, Intensive care medicine, Dementia, Internal medicine, Psychiatry, Environmental health

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Cited by: 1

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