Stem cell homing as a promising strategy for bone regeneration: focus on biomaterials Article Swipe
Shubin Liu
,
Yao Liu
,
Zhong Zheng
,
Li Bl
,
Jiaru Shao
,
Xingxu Huang
,
En Luo
,
Hong Liu
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.22203/ecm.v051a05
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.22203/ecm.v051a05
Bone regeneration, predominantly orchestrated via stem cell, holds significant implications for orthopedic and reconstructive surgery. Owing to the inherent limitations associated with stem cell transplantation and related modalities, the strategy of biomaterial-mediated endogenous stem cell homing has emerged as a promising alternative, which has garnered substantial interest from both the academic and clinical communities. This innovative approach employs chemokines and other molecular cues to direct the recruitment of endogenous stem cells to the site of bone defect, thereby promoting bone regeneration in a more physiologically relevant manner. Bone marrow is recognized as the primary niche and a major reservoir for a diverse array of stem cells. In this comprehensive review, we meticulously delineate the endogenous stem cell homing paradigm and describe the biological factors affecting stem cell homing. Moreover, we provide an in-depth analysis of the latest developments in functionally enriched biomaterials that are specifically designed to facilitate the homing, survival, and functional integration of stem cell at the site of bone injury.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.22203/ecm.v051a05
- OA Status
- gold
- Cited By
- 1
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4411681217
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4411681217Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.22203/ecm.v051a05Digital Object Identifier
- Title
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Stem cell homing as a promising strategy for bone regeneration: focus on biomaterialsWork title
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articleOpenAlex work type
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enPrimary language
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2025Year of publication
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2025-06-26Full publication date if available
- Authors
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Shubin Liu, Yao Liu, Zhong Zheng, Li Bl, Jiaru Shao, Xingxu Huang, En Luo, Hong LiuList of authors in order
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https://doi.org/10.22203/ecm.v051a05Publisher landing page
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.22203/ecm.v051a05Direct OA link when available
- Concepts
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Homing (biology), Regeneration (biology), Focus (optics), Stem cell, Cell biology, Biomedical engineering, Biology, Medicine, Physics, Ecology, OpticsTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1Per-year citation counts (last 5 years)
- Related works (count)
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10Other works algorithmically related by OpenAlex
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