Stem Cell Microarrays for Assessing Growth Factor Signaling in Engineered Glycan Microenvironments Article Swipe
Austen L. Michalak
,
Greg W. Trieger
,
Kelsey A. Trieger
,
Kamil Godula
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1002/adhm.202101232
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1002/adhm.202101232
Extracellular glycans, such as glycosaminoglycans (GAGs), provide an essential regulatory component during the development and maintenance of tissues. GAGs, which harbor binding sites for a range of growth factors (GFs) and other morphogens, help establish gradients of these molecules in the extracellular matrix (ECM) and promote the formation of active signaling complexes when presented at the cell surface. As such, GAGs have been pursued as biologically active components for the development of biomaterials for cell‐based regenerative therapies. However, their structural complexity and compositional heterogeneity make establishing structure‐function relationships for this class of glycans difficult. Here, a stem cell array platform is described, in which chemically modified heparan sulfate (HS) GAG polysaccharides are conjugated to a gelatin matrix and introduced into a polyacrylamide hydrogel network. This array allowed for direct analysis of HS contributions to the signaling via the FGF2‐dependent mitogen activated protein kinase (MAPK) pathway in mouse embryonic stem cells. With the recent emergence of powerful synthetic and recombinant technologies to produce well‐defined GAG structures, a platform for analyzing both growth factor binding and signaling in response to the presence of these biomolecules will provide a powerful tool for integrating glycans into biomaterials to advance their biological properties and applications.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/adhm.202101232
- OA Status
- green
- Cited By
- 5
- References
- 33
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W3199788658Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/adhm.202101232Digital Object Identifier
- Title
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Stem Cell Microarrays for Assessing Growth Factor Signaling in Engineered Glycan MicroenvironmentsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-09-20Full publication date if available
- Authors
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Austen L. Michalak, Greg W. Trieger, Kelsey A. Trieger, Kamil GodulaList of authors in order
- Landing page
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https://doi.org/10.1002/adhm.202101232Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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greenOpen access status per OpenAlex
- OA URL
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https://www.ncbi.nlm.nih.gov/pmc/articles/8854331Direct OA link when available
- Concepts
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Cell biology, Extracellular matrix, Stem cell, Glycan, Growth factor, Signal transduction, Chemistry, Fibroblast growth factor, Regenerative medicine, Cell signaling, Biology, Biochemistry, Glycoprotein, ReceptorTop concepts (fields/topics) attached by OpenAlex
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5Total citation count in OpenAlex
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2025: 1, 2024: 3, 2022: 1Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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