Stereodivergent Palladium-Catalyzed C–F Bond Functionalization of gem-Difluoroalkenes Article Swipe
Related Concepts
Chemistry
Palladium
Surface modification
Catalysis
Combinatorial chemistry
Medicinal chemistry
Organic chemistry
Physical chemistry
Yanhui Wang
,
Gavin Chit Tsui
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1021/acs.orglett.4c02112
· OA: W4400129684
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1021/acs.orglett.4c02112
· OA: W4400129684
We herein describe a stereodivergent C-F bond functionalization of <i>gem</i>-difluoroalkenes. Using trisubstituted β,β-difluoroacrylates, both <i>E</i> and <i>Z</i> monofluoroalkene products can be obtained with excellent diastereoselectivities. The design of two different reaction manifolds, i.e., Pd(II)- versus Pd(0)-catalyzed cross-coupling of boronic acids, is the key to stereocontrol.
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