Stereoselective Synthesis of β, γ‐Fused Bicyclic γ‐Ureasultams via an Intramolecular Mannich and aza‐Michael Addition Cascade Article Swipe
Related Concepts
Bicyclic molecule
Intramolecular force
Cascade
Stereoselectivity
Michael reaction
Chemistry
Stereochemistry
Combinatorial chemistry
Organic chemistry
Catalysis
Chromatography
Fucheng Yin
,
Lailiang Qu
,
Yifan Chen
,
Zhongwen Luo
,
Lingyi Kong
,
Xiaobing Wang
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1002/chem.202400438
· OA: W4392701860
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1002/chem.202400438
· OA: W4392701860
A novel approach has been developed for the synthesis of bicyclic β, γ ‐fused bicyclic γ ‐ureasultams containing two consecutive chiral centers through an intramolecular Mannich and aza‐Michael addition cascade of alkenyl sulfamides. The straightforward practical procedure and readily available starting materials enable the synthesis of variously substituted ureasultams. In addition, bicyclic γ ‐ureasultams is a class of potential biotin analogues.
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