Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis: A Systematic Review of Ophthalmic Management and Treatment Article Swipe
Korolos Sawires
,
Brendan Tao
,
Harrish Nithianandan
,
Larena Menant-Tay
,
Michael D. O’Connor
,
Peng Yan
,
Parnian Arjmand
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/vision9030078
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/vision9030078
Background: Stevens–Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare, life-threatening mucocutaneous disorders often associated with severe ophthalmic complications. Ocular involvement occurs in 50–68% of cases and can result in permanent vision loss. Despite this, optimal management strategies remain unclear, and treatment practices vary widely. Methods: A systematic review was conducted in accordance with PRISMA guidelines and prospectively registered on PROSPERO (CRD420251022655). Medline, Embase, and CENTRAL were searched from 1998 to 2024 for English-language studies reporting treatment outcomes for ocular SJS/TEN. Results: A total of 194 studies encompassing 6698 treated eyes were included. Best-corrected visual acuity (BCVA) improved in 52.2% of eyes, epithelial regeneration occurred in 16.8%, and symptom relief was reported in 26.3%. Common treatments included topical therapy (n = 1424), mucosal grafts (n = 1220), contact lenses (n = 1134), amniotic membrane transplantation (AMT) (n = 889), systemic medical therapy (n = 524), and punctal occlusion (n = 456). Emerging therapies included TNF-alpha inhibitors, anti-VEGF agents, photodynamic therapy, and 5-fluorouracil. Conclusions: Disease-stage-specific therapy is crucial in ocular SJS/TEN. Acute interventions such as AMT may prevent long-term complications, while chronic care targets structural and tear-film abnormalities. Further prospective studies are needed to standardize care and optimize visual outcomes.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3390/vision9030078
- https://www.mdpi.com/2411-5150/9/3/78/pdf?version=1757553997
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https://doi.org/10.3390/vision9030078Digital Object Identifier
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Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis: A Systematic Review of Ophthalmic Management and TreatmentWork title
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reviewOpenAlex work type
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2025Year of publication
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2025-09-11Full publication date if available
- Authors
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Korolos Sawires, Brendan Tao, Harrish Nithianandan, Larena Menant-Tay, Michael D. O’Connor, Peng Yan, Parnian ArjmandList of authors in order
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https://doi.org/10.3390/vision9030078Publisher landing page
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goldOpen access status per OpenAlex
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0Total citation count in OpenAlex
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| abstract_inverted_index.= | 121, 126, 131, 138, 144, 150 |
| abstract_inverted_index.A | 47, 83 |
| abstract_inverted_index.(n | 120, 125, 130, 137, 143, 149 |
| abstract_inverted_index.as | 174 |
| abstract_inverted_index.in | 23, 30, 52, 99, 106, 113, 168 |
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| abstract_inverted_index.of | 25, 85, 101 |
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| abstract_inverted_index.to | 71, 193 |
| abstract_inverted_index.194 | 86 |
| abstract_inverted_index.AMT | 175 |
| abstract_inverted_index.and | 4, 27, 41, 57, 65, 108, 146, 161, 185, 196 |
| abstract_inverted_index.are | 9, 191 |
| abstract_inverted_index.can | 28 |
| abstract_inverted_index.for | 73, 79 |
| abstract_inverted_index.may | 176 |
| abstract_inverted_index.was | 50, 111 |
| abstract_inverted_index.1998 | 70 |
| abstract_inverted_index.2024 | 72 |
| abstract_inverted_index.6698 | 89 |
| abstract_inverted_index.care | 182, 195 |
| abstract_inverted_index.eyes | 91 |
| abstract_inverted_index.from | 69 |
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| abstract_inverted_index.vary | 44 |
| abstract_inverted_index.were | 67, 92 |
| abstract_inverted_index.with | 16, 54 |
| abstract_inverted_index.(AMT) | 136 |
| abstract_inverted_index.(SJS) | 3 |
| abstract_inverted_index.(TEN) | 8 |
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| abstract_inverted_index.52.2% | 100 |
| abstract_inverted_index.524), | 145 |
| abstract_inverted_index.889), | 139 |
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| abstract_inverted_index.Toxic | 5 |
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| abstract_inverted_index.eyes, | 102 |
| abstract_inverted_index.loss. | 33 |
| abstract_inverted_index.often | 14 |
| abstract_inverted_index.rare, | 10 |
| abstract_inverted_index.this, | 35 |
| abstract_inverted_index.total | 84 |
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| abstract_inverted_index.(BCVA) | 97 |
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| abstract_inverted_index.1220), | 127 |
| abstract_inverted_index.1424), | 122 |
| abstract_inverted_index.16.8%, | 107 |
| abstract_inverted_index.26.3%. | 114 |
| abstract_inverted_index.Common | 115 |
| abstract_inverted_index.Ocular | 20 |
| abstract_inverted_index.PRISMA | 55 |
| abstract_inverted_index.acuity | 96 |
| abstract_inverted_index.grafts | 124 |
| abstract_inverted_index.lenses | 129 |
| abstract_inverted_index.needed | 192 |
| abstract_inverted_index.occurs | 22 |
| abstract_inverted_index.ocular | 80, 169 |
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| abstract_inverted_index.CENTRAL | 66 |
| abstract_inverted_index.Despite | 34 |
| abstract_inverted_index.Embase, | 64 |
| abstract_inverted_index.Further | 188 |
| abstract_inverted_index.agents, | 158 |
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| abstract_inverted_index.medical | 141 |
| abstract_inverted_index.mucosal | 123 |
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| abstract_inverted_index.treated | 90 |
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| abstract_inverted_index.50–68% | 24 |
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| abstract_inverted_index.Medline, | 63 |
| abstract_inverted_index.Methods: | 46 |
| abstract_inverted_index.PROSPERO | 61 |
| abstract_inverted_index.Results: | 82 |
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| abstract_inverted_index.anti-VEGF | 157 |
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| abstract_inverted_index.included. | 93 |
| abstract_inverted_index.long-term | 178 |
| abstract_inverted_index.occlusion | 148 |
| abstract_inverted_index.outcomes. | 199 |
| abstract_inverted_index.permanent | 31 |
| abstract_inverted_index.practices | 43 |
| abstract_inverted_index.reporting | 76 |
| abstract_inverted_index.tear-film | 186 |
| abstract_inverted_index.therapies | 153 |
| abstract_inverted_index.treatment | 42, 77 |
| abstract_inverted_index.Necrolysis | 7 |
| abstract_inverted_index.accordance | 53 |
| abstract_inverted_index.associated | 15 |
| abstract_inverted_index.epithelial | 103 |
| abstract_inverted_index.guidelines | 56 |
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| abstract_inverted_index.ophthalmic | 18 |
| abstract_inverted_index.registered | 59 |
| abstract_inverted_index.strategies | 38 |
| abstract_inverted_index.structural | 184 |
| abstract_inverted_index.systematic | 48 |
| abstract_inverted_index.treatments | 116 |
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| abstract_inverted_index.inhibitors, | 156 |
| abstract_inverted_index.involvement | 21 |
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| abstract_inverted_index.Conclusions: | 163 |
| abstract_inverted_index.encompassing | 88 |
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| abstract_inverted_index.interventions | 172 |
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| abstract_inverted_index.Best-corrected | 94 |
| abstract_inverted_index.abnormalities. | 187 |
| abstract_inverted_index.complications, | 179 |
| abstract_inverted_index.complications. | 19 |
| abstract_inverted_index.5-fluorouracil. | 162 |
| abstract_inverted_index.transplantation | 135 |
| abstract_inverted_index.English-language | 74 |
| abstract_inverted_index.life-threatening | 11 |
| abstract_inverted_index.Stevens–Johnson | 1 |
| abstract_inverted_index.(CRD420251022655). | 62 |
| abstract_inverted_index.Disease-stage-specific | 164 |
| cited_by_percentile_year | |
| corresponding_author_ids | https://openalex.org/A5033468037 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 7 |
| corresponding_institution_ids | https://openalex.org/I185261750, https://openalex.org/I530967 |
| citation_normalized_percentile.value | 0.44310214 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |