Stimulation of ROS Generation by Extract of Warburgia ugandensis Leading to G0/G1 Cell Cycle Arrest and Antiproliferation in A549 Cells Article Swipe
Yongli Zhang
,
Guilin Chen
,
Ye Liu
,
Xiao-Cui Zhuang
,
Mingquan Guo
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/antiox10101559
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/antiox10101559
Warburgia ugandensis Sprague (WU) is a traditional medicinal plant used for the treatment of various diseases, including cancer, in Africa. This study aimed to evaluate the anti-non-small cell lung cancer (NSCLC) activities of WU against A549 cells and to reveal potential molecular mechanisms. The cytotoxicity of various WU extracts was evaluated with HeLa (cervical cancer), HepG2 (liver cancer), HT-29 (colorectal cancer), and A549 (non-small cell lung cancer) cells by means of Sulforhodamine B (SRB) assay. Therein, the dimethyl carbonate extract of WU (WUD) was tested with the most potent anti-proliferative activity against the four cancer cell lines, and its effects on cell viability, cell cycle progression, DNA damage, intracellular reactive oxygen species (ROS), and expression levels of G0/G1-related proteins in A549 cells were further examined. First, it was found that WUD inhibited the proliferation of A549 cells in a time- and dose-dependent manner. In addition, WUD induced G0/G1 phase arrest and modulated the expression of G0/G1 phase-associated proteins Cyclin D1, Cyclin E1, and P27 in A549 cells. Furthermore, WUD increased the protein abundance of P27 by inhibiting FOXO3A/SKP2 axis-mediated protein degradation and also significantly induced the γH2AX expression and intracellular ROS generation of A549 cells. It was also found that the inhibitory effect of WUD on the proliferation and G0/G1 cell cycle progression of A549 cells could be attenuated by NAC, a ROS scavenger. On the other hand, phytochemical analysis of WUD with UPLC-QTOF-MS/MS indicated 10 sesquiterpenoid compounds. In conclusion, WUD exhibited remarkable anti-proliferative effects on A549 cells by improving the intracellular ROS level and by subsequently modulating the cell proliferation and G0/G1 cell cycle progression of A549 cells. These findings proved the good therapeutic potential of WU for the treatment of NSCLC.
Related Topics
Concepts
A549 cell
Cell cycle
Cell cycle checkpoint
Cell growth
Viability assay
Cancer cell
Chemistry
HeLa
G1 phase
Cyclin E
Biology
Cell biology
Molecular biology
Cyclin D1
Cancer research
Cell
Cancer
Biochemistry
Genetics
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/antiox10101559
- https://www.mdpi.com/2076-3921/10/10/1559/pdf?version=1634719848
- OA Status
- gold
- Cited By
- 12
- References
- 77
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3203222678
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3203222678Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/antiox10101559Digital Object Identifier
- Title
-
Stimulation of ROS Generation by Extract of Warburgia ugandensis Leading to G0/G1 Cell Cycle Arrest and Antiproliferation in A549 CellsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-09-30Full publication date if available
- Authors
-
Yongli Zhang, Guilin Chen, Ye Liu, Xiao-Cui Zhuang, Mingquan GuoList of authors in order
- Landing page
-
https://doi.org/10.3390/antiox10101559Publisher landing page
- PDF URL
-
https://www.mdpi.com/2076-3921/10/10/1559/pdf?version=1634719848Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
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https://www.mdpi.com/2076-3921/10/10/1559/pdf?version=1634719848Direct OA link when available
- Concepts
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A549 cell, Cell cycle, Cell cycle checkpoint, Cell growth, Viability assay, Cancer cell, Chemistry, HeLa, G1 phase, Cyclin E, Biology, Cell biology, Molecular biology, Cyclin D1, Cancer research, Cell, Cancer, Biochemistry, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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12Total citation count in OpenAlex
- Citations by year (recent)
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2025: 3, 2024: 2, 2023: 4, 2022: 2, 2021: 1Per-year citation counts (last 5 years)
- References (count)
-
77Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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