Strength of interactions in the Notch gene regulatory network determines patterning and fate in the notochord Article Swipe
Héctor Sánchez-Iranzo
,
Aliaksandr Halavatyi
,
Alba Diz-Muñoz
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.5445/ir/1000152242
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.5445/ir/1000152242
Development of multicellular organisms requires the generation of gene expression patterns that determines cell fate and organ shape. Groups of genetic interactions known as Gene Regulatory Networks (GRNs) play a key role in the generation of such patterns. However, how the topology and parameters of GRNs determine patterning in vivo remains unclear due to the complexity of most experimental systems. To address this, we use the zebrafish notochord, an organ where coin-shaped precursor cells are initially arranged in a simple unidimensional geometry. These cells then differentiate into vacuolated and sheath cells. Using newly developed transgenic tools together with in vivo imaging, we identify jag1a and her6/her9 as the main components of a Notch GRN that generates a lateral inhibition pattern and determines cell fate. Making use of this experimental system and mathematical modeling we show that lateral inhibition patterning is promoted when ligand-receptor interactions are stronger within the same cell than in neighboring cells. Altogether, we establish the zebrafish notochord as an experimental system to study pattern generation, and identify and characterize how the properties of GRNs determine self-organization of gene patterning and cell fate.
Related Topics
Concepts
Notochord
Zebrafish
Cell fate determination
Multicellular organism
Gene regulatory network
Biology
Notch signaling pathway
Cell biology
Regulation of gene expression
Cell type
Cell
Gene
Gene expression
Signal transduction
Genetics
Embryogenesis
Transcription factor
Embryo
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://publikationen.bibliothek.kit.edu/1000152242
- OA Status
- green
- Cited By
- 1
- References
- 82
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3197446343
All OpenAlex metadata
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https://doi.org/10.5445/ir/1000152242Digital Object Identifier
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Strength of interactions in the Notch gene regulatory network determines patterning and fate in the notochordWork title
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
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2022-01-01Full publication date if available
- Authors
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Héctor Sánchez-Iranzo, Aliaksandr Halavatyi, Alba Diz-MuñozList of authors in order
- Landing page
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https://publikationen.bibliothek.kit.edu/1000152242Publisher landing page
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YesWhether a free full text is available
- OA status
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greenOpen access status per OpenAlex
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https://publikationen.bibliothek.kit.edu/1000152242Direct OA link when available
- Concepts
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Notochord, Zebrafish, Cell fate determination, Multicellular organism, Gene regulatory network, Biology, Notch signaling pathway, Cell biology, Regulation of gene expression, Cell type, Cell, Gene, Gene expression, Signal transduction, Genetics, Embryogenesis, Transcription factor, EmbryoTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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2022: 1Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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| primary_location.raw_source_name | eLife, 11, Art.-Nr.: e75429 |
| primary_location.landing_page_url | https://publikationen.bibliothek.kit.edu/1000152242 |
| publication_date | 2022-01-01 |
| publication_year | 2022 |
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