Striatal Crosstalk Between Dopamine and Serotonin Systems Article Swipe

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Yu Liu , Juan Enríquez-Traba , Christian Lüscher ·

YOU? · · 2025 · Open Access · · DOI: https://doi.org/10.7554/elife.107252

Dopamine (DA) and serotonin (5-HT) are neuromodulators in reward processing, decision- making, and motivated behavior. While often viewed as opposing or complementary systems, how DA and 5-HT release integrate in the striatum remains elusive. Using optogenetics, fiber photometry, and slice electrophysiology, we found that ventral tegmental area (VTA) DA neuron stimulation increased DA release without affecting 5-HT release. Dorsal raphe nucleus (DRN) 5-HT neuron activation, on the other hand, induced serotonin release and a transient increase in DA in the NAc, likely via glutamate co-release onto VTA DA neurons during the initial stimulation phase. These findings indicate that DA and 5-HT operate largely independently in the striatum, with selective circuit-dependent interactions. This work refines our understanding of DA-5HT interactions and provides a foundation for future research into their roles in motivated behaviors and neuropsychiatric disorders.

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Dopamine Serotonin Crosstalk Neuroscience Psychology Medicine Physics Internal medicine Optics Receptor

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Type: preprint
Language: en
Landing Page: https://doi.org/10.7554/elife.107252
OA Status: gold
References: 39
Related Works: 10
OpenAlex ID: https://openalex.org/W4412478764

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DOI: https://doi.org/10.7554/elife.107252

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Title: Striatal Crosstalk Between Dopamine and Serotonin Systems

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Type: preprint

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Language: en

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Publication year: 2025

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Publication date: 2025-07-16

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Authors: Yu Liu, Juan Enríquez-Traba, Christian Lüscher

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Landing page: https://doi.org/10.7554/elife.107252

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Concepts: Dopamine, Serotonin, Crosstalk, Neuroscience, Psychology, Medicine, Physics, Internal medicine, Optics, Receptor

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Cited by: 0

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References (count): 39

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