Stromal-Vascular Fraction and Adipose-derived Stem Cell Therapies Improve Cartilage Regeneration in Osteoarthritis-induced Rats Article Swipe
Wanting Yang
,
Chun‐Yen Ke
,
Kuang‐Ting Yeh
,
Shyh-Geng Huang
,
Ziyang Lin
,
Wen‐Tien Wu
,
Ru‐Ping Lee
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-674309/v1
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-674309/v1
BackgroundThis study evaluated the effects of the stromal vascular fraction (SVF) and adipose-derived stem cells (ADSCs) on cartilage injury in an osteoarthritis (OA) rat model. MethodsSodium iodoacetate (3 mg/50 μL) was used to induce OA in the left knee joint of rats. On day 14 after OA induction, 50 μL of SVF (5 × 10 6 cells), ADSCs (1 × 10 6 cells), or 0.9% normal saline (NS) was injected into the left knee-joint cavity of each group. ResultsA macroscopic view of the articular cartilage revealed a damaged, concave, and inflamed appearance in the NS group. Histological sections revealed that the cartilage in the NS group was uneven and thin and had hyperchromatic cell infiltration. Notably, the conditions of articular cartilages improved on day 7 after the SVF and ADSC treatments. Furthermore, the cartilage surface had recovered to nearly normal and appeared smooth and bright on day 14 in the SVF and ADSC groups, and a thick cartilage layer was observed on histology. Additionally, the white blood cell counts in the SVF and ADSC groups were higher than those in the NS group on day 14. Plasma IL-1β levels on days 7 and 14 were reduced in the SVF and ADSC groups. ConclusionThese results indicated that both SVF and ADSC treatments may assist in articular cartilage regeneration after cartilage injury. Cell therapy may benefit patients with OA. However, clinical trials with humans are required before the application of SVF and ADSC treatments in patients with OA.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.3.rs-674309/v1
- https://www.researchsquare.com/article/rs-674309/latest.pdf
- OA Status
- green
- Cited By
- 2
- References
- 22
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3181891232
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3181891232Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.21203/rs.3.rs-674309/v1Digital Object Identifier
- Title
-
Stromal-Vascular Fraction and Adipose-derived Stem Cell Therapies Improve Cartilage Regeneration in Osteoarthritis-induced RatsWork title
- Type
-
preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
-
2021-07-08Full publication date if available
- Authors
-
Wanting Yang, Chun‐Yen Ke, Kuang‐Ting Yeh, Shyh-Geng Huang, Ziyang Lin, Wen‐Tien Wu, Ru‐Ping LeeList of authors in order
- Landing page
-
https://doi.org/10.21203/rs.3.rs-674309/v1Publisher landing page
- PDF URL
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https://www.researchsquare.com/article/rs-674309/latest.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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greenOpen access status per OpenAlex
- OA URL
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https://www.researchsquare.com/article/rs-674309/latest.pdfDirect OA link when available
- Concepts
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Stromal vascular fraction, Osteoarthritis, Adipose tissue, Regeneration (biology), Cartilage, Stromal cell, Stem cell, Mesenchymal stem cell, Cell biology, Medicine, Chemistry, Anatomy, Pathology, Endocrinology, Biology, Alternative medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
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2Total citation count in OpenAlex
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2024: 2Per-year citation counts (last 5 years)
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22Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| publication_date | 2021-07-08 |
| publication_year | 2021 |
| referenced_works | https://openalex.org/W2574647359, https://openalex.org/W1991120653, https://openalex.org/W2062491356, https://openalex.org/W2506184976, https://openalex.org/W2804495543, https://openalex.org/W3045295790, https://openalex.org/W1992595819, https://openalex.org/W2319952279, https://openalex.org/W2041636732, https://openalex.org/W2321700513, https://openalex.org/W3112676006, https://openalex.org/W2124136951, https://openalex.org/W2625285338, https://openalex.org/W2041891376, https://openalex.org/W2081563776, https://openalex.org/W2007762572, https://openalex.org/W2078410116, https://openalex.org/W2133075927, https://openalex.org/W1500980542, https://openalex.org/W2741507210, https://openalex.org/W2048785624, https://openalex.org/W2099669252 |
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