Structural and functional characterization of the Curli adaptor protein CsgF Article Swipe
Tobias Schubeis
,
Johannes Spehr
,
Janika Viereck
,
Laura Köpping
,
Madhu Nagaraj
,
Mumdooh A.M. Ahmed
,
Christiane Ritter
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1002/1873-3468.13002
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1002/1873-3468.13002
Curli are functional amyloids that form a major part of the biofilm produced by many enterobacteriaceae. A multiprotein system around the outer membrane protein CsgG is in charge of the export and controlled propagation of the main Curli subunits, CsgA and CsgB. CsgF is essential for the linkage of the main amyloid‐forming proteins to the cell surface. Here, we present a profound biochemical and biophysical characterization of recombinant CsgF, highlighted by a solution NMR structure of CsgF in the presence of dihexanoylphosphocholine micelles. Interestingly, CsgF contains large unstructured domains and does not show a globular fold. The data presented shed new light on the molecular mechanism of Curli amyloid surface attachment.
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Metadata
- Type
- letter
- Language
- en
- Landing Page
- https://doi.org/10.1002/1873-3468.13002
- https://febs.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1873-3468.13002
- OA Status
- bronze
- Cited By
- 27
- References
- 36
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2789629259
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https://openalex.org/W2789629259Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/1873-3468.13002Digital Object Identifier
- Title
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Structural and functional characterization of the Curli adaptor protein CsgFWork title
- Type
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letterOpenAlex work type
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enPrimary language
- Publication year
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2018Year of publication
- Publication date
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2018-02-10Full publication date if available
- Authors
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Tobias Schubeis, Johannes Spehr, Janika Viereck, Laura Köpping, Madhu Nagaraj, Mumdooh A.M. Ahmed, Christiane RitterList of authors in order
- Landing page
-
https://doi.org/10.1002/1873-3468.13002Publisher landing page
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https://febs.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1873-3468.13002Direct link to full text PDF
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YesWhether a free full text is available
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bronzeOpen access status per OpenAlex
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https://febs.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1873-3468.13002Direct OA link when available
- Concepts
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Biofilm, Amyloid (mycology), Biophysics, Bacterial outer membrane, Recombinant DNA, Chemistry, Characterization (materials science), Cell biology, Biochemistry, Bacteria, Escherichia coli, Biology, Nanotechnology, Materials science, Gene, Genetics, Inorganic chemistryTop concepts (fields/topics) attached by OpenAlex
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27Total citation count in OpenAlex
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2025: 1, 2024: 1, 2023: 3, 2022: 2, 2021: 3Per-year citation counts (last 5 years)
- References (count)
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36Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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