Structural and Functional Diversity of Animal Toxins Interacting With GPCRs Article Swipe
Anne-Cécile van Baelen
,
Philippe Robin
,
Pascal Kessler
,
Arhamatoulaye Maïga
,
Nicolas Gilles
,
Denis Servent
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3389/fmolb.2022.811365
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3389/fmolb.2022.811365
Peptide toxins from venoms have undergone a long evolutionary process allowing host defense or prey capture and making them highly selective and potent for their target. This has resulted in the emergence of a large panel of toxins from a wide diversity of species, with varied structures and multiple associated biological functions. In this way, animal toxins constitute an inexhaustible reservoir of druggable molecules due to their interesting pharmacological properties. One of the most interesting classes of therapeutic targets is the G-protein coupled receptors (GPCRs). GPCRs represent the largest family of membrane receptors in mammals with approximately 800 different members. They are involved in almost all biological functions and are the target of almost 30% of drugs currently on the market. Given the interest of GPCRs in the therapeutic field, the study of toxins that can interact with and modulate their activity with the purpose of drug development is of particular importance. The present review focuses on toxins targeting GPCRs, including peptide-interacting receptors or aminergic receptors, with a particular focus on structural aspects and, when relevant, on potential medical applications. The toxins described here exhibit a great diversity in size, from 10 to 80 amino acids long, in disulfide bridges, from none to five, and belong to a large panel of structural scaffolds. Particular toxin structures developed here include inhibitory cystine knot (ICK), three-finger fold, and Kunitz-type toxins. We summarize current knowledge on the structural and functional diversity of toxins interacting with GPCRs, concerning first the agonist-mimicking toxins that act as endogenous agonists targeting the corresponding receptor, and second the toxins that differ structurally from natural agonists and which display agonist, antagonist, or allosteric properties.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3389/fmolb.2022.811365
- OA Status
- gold
- Cited By
- 15
- References
- 233
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4210601043
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4210601043Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fmolb.2022.811365Digital Object Identifier
- Title
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Structural and Functional Diversity of Animal Toxins Interacting With GPCRsWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-02-07Full publication date if available
- Authors
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Anne-Cécile van Baelen, Philippe Robin, Pascal Kessler, Arhamatoulaye Maïga, Nicolas Gilles, Denis ServentList of authors in order
- Landing page
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https://doi.org/10.3389/fmolb.2022.811365Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.3389/fmolb.2022.811365Direct OA link when available
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G protein-coupled receptor, Druggability, Biology, Receptor, Computational biology, Functional diversity, Drug discovery, Structural motif, Bioinformatics, Biochemistry, Ecology, GeneTop concepts (fields/topics) attached by OpenAlex
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15Total citation count in OpenAlex
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2025: 3, 2024: 3, 2023: 6, 2022: 3Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.is | 79, 148 |
| abstract_inverted_index.of | 32, 36, 42, 61, 71, 76, 90, 112, 115, 124, 132, 145, 149, 210, 238 |
| abstract_inverted_index.on | 118, 156, 170, 176, 232 |
| abstract_inverted_index.or | 13, 163, 272 |
| abstract_inverted_index.to | 65, 192, 202, 206 |
| abstract_inverted_index.30% | 114 |
| abstract_inverted_index.800 | 97 |
| abstract_inverted_index.One | 70 |
| abstract_inverted_index.The | 152, 180 |
| abstract_inverted_index.act | 249 |
| abstract_inverted_index.all | 105 |
| abstract_inverted_index.and | 16, 21, 47, 108, 138, 204, 225, 235, 257, 267 |
| abstract_inverted_index.are | 101, 109 |
| abstract_inverted_index.can | 135 |
| abstract_inverted_index.due | 64 |
| abstract_inverted_index.for | 23 |
| abstract_inverted_index.has | 27 |
| abstract_inverted_index.the | 30, 72, 80, 87, 110, 119, 122, 127, 130, 143, 233, 245, 254, 259 |
| abstract_inverted_index.They | 100 |
| abstract_inverted_index.This | 26 |
| abstract_inverted_index.and, | 173 |
| abstract_inverted_index.drug | 146 |
| abstract_inverted_index.from | 2, 38, 190, 200, 264 |
| abstract_inverted_index.have | 4 |
| abstract_inverted_index.here | 183, 217 |
| abstract_inverted_index.host | 11 |
| abstract_inverted_index.knot | 221 |
| abstract_inverted_index.long | 7 |
| abstract_inverted_index.most | 73 |
| abstract_inverted_index.none | 201 |
| abstract_inverted_index.prey | 14 |
| abstract_inverted_index.that | 134, 248, 261 |
| abstract_inverted_index.them | 18 |
| abstract_inverted_index.this | 53 |
| abstract_inverted_index.way, | 54 |
| abstract_inverted_index.when | 174 |
| abstract_inverted_index.wide | 40 |
| abstract_inverted_index.with | 44, 95, 137, 142, 166, 241 |
| abstract_inverted_index.GPCRs | 85, 125 |
| abstract_inverted_index.Given | 121 |
| abstract_inverted_index.acids | 195 |
| abstract_inverted_index.amino | 194 |
| abstract_inverted_index.drugs | 116 |
| abstract_inverted_index.first | 244 |
| abstract_inverted_index.five, | 203 |
| abstract_inverted_index.focus | 169 |
| abstract_inverted_index.fold, | 224 |
| abstract_inverted_index.great | 186 |
| abstract_inverted_index.large | 34, 208 |
| abstract_inverted_index.long, | 196 |
| abstract_inverted_index.panel | 35, 209 |
| abstract_inverted_index.size, | 189 |
| abstract_inverted_index.study | 131 |
| abstract_inverted_index.their | 24, 66, 140 |
| abstract_inverted_index.toxin | 214 |
| abstract_inverted_index.which | 268 |
| abstract_inverted_index.(ICK), | 222 |
| abstract_inverted_index.GPCRs, | 159, 242 |
| abstract_inverted_index.almost | 104, 113 |
| abstract_inverted_index.animal | 55 |
| abstract_inverted_index.belong | 205 |
| abstract_inverted_index.differ | 262 |
| abstract_inverted_index.family | 89 |
| abstract_inverted_index.field, | 129 |
| abstract_inverted_index.highly | 19 |
| abstract_inverted_index.making | 17 |
| abstract_inverted_index.potent | 22 |
| abstract_inverted_index.review | 154 |
| abstract_inverted_index.second | 258 |
| abstract_inverted_index.target | 111 |
| abstract_inverted_index.toxins | 1, 37, 56, 133, 157, 181, 239, 247, 260 |
| abstract_inverted_index.varied | 45 |
| abstract_inverted_index.venoms | 3 |
| abstract_inverted_index.Peptide | 0 |
| abstract_inverted_index.aspects | 172 |
| abstract_inverted_index.capture | 15 |
| abstract_inverted_index.classes | 75 |
| abstract_inverted_index.coupled | 82 |
| abstract_inverted_index.current | 230 |
| abstract_inverted_index.cystine | 220 |
| abstract_inverted_index.defense | 12 |
| abstract_inverted_index.display | 269 |
| abstract_inverted_index.exhibit | 184 |
| abstract_inverted_index.focuses | 155 |
| abstract_inverted_index.include | 218 |
| abstract_inverted_index.largest | 88 |
| abstract_inverted_index.mammals | 94 |
| abstract_inverted_index.market. | 120 |
| abstract_inverted_index.medical | 178 |
| abstract_inverted_index.natural | 265 |
| abstract_inverted_index.present | 153 |
| abstract_inverted_index.process | 9 |
| abstract_inverted_index.purpose | 144 |
| abstract_inverted_index.target. | 25 |
| abstract_inverted_index.targets | 78 |
| abstract_inverted_index.toxins. | 227 |
| abstract_inverted_index.(GPCRs). | 84 |
| abstract_inverted_index.activity | 141 |
| abstract_inverted_index.agonist, | 270 |
| abstract_inverted_index.agonists | 252, 266 |
| abstract_inverted_index.allowing | 10 |
| abstract_inverted_index.bridges, | 199 |
| abstract_inverted_index.interact | 136 |
| abstract_inverted_index.interest | 123 |
| abstract_inverted_index.involved | 102 |
| abstract_inverted_index.members. | 99 |
| abstract_inverted_index.membrane | 91 |
| abstract_inverted_index.modulate | 139 |
| abstract_inverted_index.multiple | 48 |
| abstract_inverted_index.resulted | 28 |
| abstract_inverted_index.species, | 43 |
| abstract_inverted_index.G-protein | 81 |
| abstract_inverted_index.aminergic | 164 |
| abstract_inverted_index.currently | 117 |
| abstract_inverted_index.described | 182 |
| abstract_inverted_index.developed | 216 |
| abstract_inverted_index.different | 98 |
| abstract_inverted_index.disulfide | 198 |
| abstract_inverted_index.diversity | 41, 187, 237 |
| abstract_inverted_index.druggable | 62 |
| abstract_inverted_index.emergence | 31 |
| abstract_inverted_index.functions | 107 |
| abstract_inverted_index.including | 160 |
| abstract_inverted_index.knowledge | 231 |
| abstract_inverted_index.molecules | 63 |
| abstract_inverted_index.potential | 177 |
| abstract_inverted_index.receptor, | 256 |
| abstract_inverted_index.receptors | 83, 92, 162 |
| abstract_inverted_index.relevant, | 175 |
| abstract_inverted_index.represent | 86 |
| abstract_inverted_index.reservoir | 60 |
| abstract_inverted_index.selective | 20 |
| abstract_inverted_index.summarize | 229 |
| abstract_inverted_index.targeting | 158, 253 |
| abstract_inverted_index.undergone | 5 |
| abstract_inverted_index.Particular | 213 |
| abstract_inverted_index.allosteric | 273 |
| abstract_inverted_index.associated | 49 |
| abstract_inverted_index.biological | 50, 106 |
| abstract_inverted_index.concerning | 243 |
| abstract_inverted_index.constitute | 57 |
| abstract_inverted_index.endogenous | 251 |
| abstract_inverted_index.functional | 236 |
| abstract_inverted_index.functions. | 51 |
| abstract_inverted_index.inhibitory | 219 |
| abstract_inverted_index.particular | 150, 168 |
| abstract_inverted_index.receptors, | 165 |
| abstract_inverted_index.scaffolds. | 212 |
| abstract_inverted_index.structural | 171, 211, 234 |
| abstract_inverted_index.structures | 46, 215 |
| abstract_inverted_index.Kunitz-type | 226 |
| abstract_inverted_index.antagonist, | 271 |
| abstract_inverted_index.development | 147 |
| abstract_inverted_index.importance. | 151 |
| abstract_inverted_index.interacting | 240 |
| abstract_inverted_index.interesting | 67, 74 |
| abstract_inverted_index.properties. | 69, 274 |
| abstract_inverted_index.therapeutic | 77, 128 |
| abstract_inverted_index.evolutionary | 8 |
| abstract_inverted_index.structurally | 263 |
| abstract_inverted_index.three-finger | 223 |
| abstract_inverted_index.applications. | 179 |
| abstract_inverted_index.approximately | 96 |
| abstract_inverted_index.corresponding | 255 |
| abstract_inverted_index.inexhaustible | 59 |
| abstract_inverted_index.pharmacological | 68 |
| abstract_inverted_index.agonist-mimicking | 246 |
| abstract_inverted_index.peptide-interacting | 161 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 96 |
| corresponding_author_ids | https://openalex.org/A5017059477 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 6 |
| corresponding_institution_ids | https://openalex.org/I2738703131, https://openalex.org/I277688954, https://openalex.org/I4210128565 |
| citation_normalized_percentile.value | 0.82505208 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |