Structural basis for collagen recognition by the Streptococcus pyogenes M3 protein and its involvement in biofilm Article Swipe
Marta Wojnowska
,
Takeaki Wajima
,
Tamas Yelland
,
Hannes Ludewig
,
Robert M. Hagan
,
George Watt
,
Samir W. Hamaia
,
Dominique Bihan
,
Jean‐Daniel Malcor
,
Arkadiusz Bonna
,
Helena Bergsten
,
Mattias Svensson
,
Oddvar Oppegaard
,
Steinar Skrede
,
Per Arnell
,
Ole Hyldegaard
,
Richard W. Farndale
,
Anna Norrby‐Teglund
,
Ulrich Schwarz‐Linek
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.7554/elife.105539.1
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.7554/elife.105539.1
The M protein is an essential virulence factor of Streptococcus pyogenes, or group A streptococci (GAS), one of the most common and dangerous human pathogens. Molecular and functional characterization of M protein variants and their interactions with host components is crucial for understanding streptococcal pathogenesis and vaccine development. The M3 protein is produced by the prevalent emm3 GAS serotype, which is frequently associated with severe invasive diseases. Here we characterize the interaction of M3 with human collagens through detailed structural and biochemical binding analysis. High-resolution structures of the N-terminal M3 domain in the free state as well as bound to a collagen peptide derived from the Collagen Ligands Collection reveal a novel T-shaped protein fold that presents binding sites complementing the characteristic topology of collagen triple helices. The structure of the M3/collagen peptide complex explains how emm3 GAS and related streptococci, such as the emerging human pathogen Streptococcus dysgalactiae subsp. equisimilis, can target collagens to enable colonization of various tissues. In line with this, we demonstrate that the M3/collagen interaction promotes enhanced biofilm formation of emm3 GAS in an emm type specific manner, which can be inhibited with the recombinant M3 N-terminal domain fragment. Further, emm3 GAS, but not an emm1 strain, are shown to colocalize with collagen in tissue biopsies from patients with necrotizing soft tissue infections, where GAS biofilms are common. This observation is reproduced in organotypic skin models. Together, these data provide detailed molecular insights into an important streptococcal virulence mechanism with implications for the understanding of invasive infections, strategies for treating biofilm and M-protein based vaccine design.
Related Topics
Concepts
Streptococcus pyogenes
Biofilm
Microbiology
Basis (linear algebra)
Chemistry
Biology
Bacteria
Mathematics
Genetics
Staphylococcus aureus
Geometry
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.7554/elife.105539.1
- OA Status
- gold
- Cited By
- 1
- References
- 69
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4408359651
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4408359651Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.7554/elife.105539.1Digital Object Identifier
- Title
-
Structural basis for collagen recognition by the Streptococcus pyogenes M3 protein and its involvement in biofilmWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-03-12Full publication date if available
- Authors
-
Marta Wojnowska, Takeaki Wajima, Tamas Yelland, Hannes Ludewig, Robert M. Hagan, George Watt, Samir W. Hamaia, Dominique Bihan, Jean‐Daniel Malcor, Arkadiusz Bonna, Helena Bergsten, Mattias Svensson, Oddvar Oppegaard, Steinar Skrede, Per Arnell, Ole Hyldegaard, Richard W. Farndale, Anna Norrby‐Teglund, Ulrich Schwarz‐LinekList of authors in order
- Landing page
-
https://doi.org/10.7554/elife.105539.1Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.7554/elife.105539.1Direct OA link when available
- Concepts
-
Streptococcus pyogenes, Biofilm, Microbiology, Basis (linear algebra), Chemistry, Biology, Bacteria, Mathematics, Genetics, Staphylococcus aureus, GeometryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1Per-year citation counts (last 5 years)
- References (count)
-
69Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4408359651 |
|---|---|
| doi | https://doi.org/10.7554/elife.105539.1 |
| ids.doi | https://doi.org/10.7554/elife.105539.1 |
| ids.openalex | https://openalex.org/W4408359651 |
| fwci | 6.47427621 |
| type | preprint |
| title | Structural basis for collagen recognition by the Streptococcus pyogenes M3 protein and its involvement in biofilm |
| biblio.issue | |
| biblio.volume | |
| biblio.last_page | |
| biblio.first_page | |
| topics[0].id | https://openalex.org/T11153 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 1.0 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2739 |
| topics[0].subfield.display_name | Public Health, Environmental and Occupational Health |
| topics[0].display_name | Streptococcal Infections and Treatments |
| topics[1].id | https://openalex.org/T12297 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9843999743461609 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2725 |
| topics[1].subfield.display_name | Infectious Diseases |
| topics[1].display_name | Otolaryngology and Infectious Diseases |
| topics[2].id | https://openalex.org/T11551 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9765999913215637 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2713 |
| topics[2].subfield.display_name | Epidemiology |
| topics[2].display_name | Infective Endocarditis Diagnosis and Management |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C2779306812 |
| concepts[0].level | 4 |
| concepts[0].score | 0.8757827281951904 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q131271 |
| concepts[0].display_name | Streptococcus pyogenes |
| concepts[1].id | https://openalex.org/C58123911 |
| concepts[1].level | 3 |
| concepts[1].score | 0.8128015995025635 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q467410 |
| concepts[1].display_name | Biofilm |
| concepts[2].id | https://openalex.org/C89423630 |
| concepts[2].level | 1 |
| concepts[2].score | 0.5978692770004272 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q7193 |
| concepts[2].display_name | Microbiology |
| concepts[3].id | https://openalex.org/C12426560 |
| concepts[3].level | 2 |
| concepts[3].score | 0.5118185877799988 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q189569 |
| concepts[3].display_name | Basis (linear algebra) |
| concepts[4].id | https://openalex.org/C185592680 |
| concepts[4].level | 0 |
| concepts[4].score | 0.4114489257335663 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[4].display_name | Chemistry |
| concepts[5].id | https://openalex.org/C86803240 |
| concepts[5].level | 0 |
| concepts[5].score | 0.3045486807823181 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[5].display_name | Biology |
| concepts[6].id | https://openalex.org/C523546767 |
| concepts[6].level | 2 |
| concepts[6].score | 0.14451643824577332 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q10876 |
| concepts[6].display_name | Bacteria |
| concepts[7].id | https://openalex.org/C33923547 |
| concepts[7].level | 0 |
| concepts[7].score | 0.12387546896934509 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q395 |
| concepts[7].display_name | Mathematics |
| concepts[8].id | https://openalex.org/C54355233 |
| concepts[8].level | 1 |
| concepts[8].score | 0.08850950002670288 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[8].display_name | Genetics |
| concepts[9].id | https://openalex.org/C2779489039 |
| concepts[9].level | 3 |
| concepts[9].score | 0.0703062117099762 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q188121 |
| concepts[9].display_name | Staphylococcus aureus |
| concepts[10].id | https://openalex.org/C2524010 |
| concepts[10].level | 1 |
| concepts[10].score | 0.0 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q8087 |
| concepts[10].display_name | Geometry |
| keywords[0].id | https://openalex.org/keywords/streptococcus-pyogenes |
| keywords[0].score | 0.8757827281951904 |
| keywords[0].display_name | Streptococcus pyogenes |
| keywords[1].id | https://openalex.org/keywords/biofilm |
| keywords[1].score | 0.8128015995025635 |
| keywords[1].display_name | Biofilm |
| keywords[2].id | https://openalex.org/keywords/microbiology |
| keywords[2].score | 0.5978692770004272 |
| keywords[2].display_name | Microbiology |
| keywords[3].id | https://openalex.org/keywords/basis |
| keywords[3].score | 0.5118185877799988 |
| keywords[3].display_name | Basis (linear algebra) |
| keywords[4].id | https://openalex.org/keywords/chemistry |
| keywords[4].score | 0.4114489257335663 |
| keywords[4].display_name | Chemistry |
| keywords[5].id | https://openalex.org/keywords/biology |
| keywords[5].score | 0.3045486807823181 |
| keywords[5].display_name | Biology |
| keywords[6].id | https://openalex.org/keywords/bacteria |
| keywords[6].score | 0.14451643824577332 |
| keywords[6].display_name | Bacteria |
| keywords[7].id | https://openalex.org/keywords/mathematics |
| keywords[7].score | 0.12387546896934509 |
| keywords[7].display_name | Mathematics |
| keywords[8].id | https://openalex.org/keywords/genetics |
| keywords[8].score | 0.08850950002670288 |
| keywords[8].display_name | Genetics |
| keywords[9].id | https://openalex.org/keywords/staphylococcus-aureus |
| keywords[9].score | 0.0703062117099762 |
| keywords[9].display_name | Staphylococcus aureus |
| language | en |
| locations[0].id | doi:10.7554/elife.105539.1 |
| locations[0].is_oa | True |
| locations[0].source | |
| locations[0].license | cc-by |
| locations[0].pdf_url | |
| locations[0].version | acceptedVersion |
| locations[0].raw_type | posted-content |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | False |
| locations[0].raw_source_name | |
| locations[0].landing_page_url | https://doi.org/10.7554/elife.105539.1 |
| indexed_in | crossref |
| authorships[0].author.id | https://openalex.org/A5070455235 |
| authorships[0].author.orcid | https://orcid.org/0000-0001-8954-5127 |
| authorships[0].author.display_name | Marta Wojnowska |
| authorships[0].countries | GB |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I16835326 |
| authorships[0].affiliations[0].raw_affiliation_string | Biomedical Sciences Research Complex, University of St Andrews |
| authorships[0].institutions[0].id | https://openalex.org/I16835326 |
| authorships[0].institutions[0].ror | https://ror.org/02wn5qz54 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I16835326 |
| authorships[0].institutions[0].country_code | GB |
| authorships[0].institutions[0].display_name | University of St Andrews |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Marta Wojnowska |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Biomedical Sciences Research Complex, University of St Andrews |
| authorships[1].author.id | https://openalex.org/A5089140575 |
| authorships[1].author.orcid | https://orcid.org/0000-0001-9506-707X |
| authorships[1].author.display_name | Takeaki Wajima |
| authorships[1].countries | SE |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I1335113835 |
| authorships[1].affiliations[0].raw_affiliation_string | Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge |
| authorships[1].institutions[0].id | https://openalex.org/I1335113835 |
| authorships[1].institutions[0].ror | https://ror.org/00m8d6786 |
| authorships[1].institutions[0].type | healthcare |
| authorships[1].institutions[0].lineage | https://openalex.org/I1335113835 |
| authorships[1].institutions[0].country_code | SE |
| authorships[1].institutions[0].display_name | Karolinska University Hospital |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Takeaki Wajima |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge |
| authorships[2].author.id | https://openalex.org/A5088014114 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-1975-0114 |
| authorships[2].author.display_name | Tamas Yelland |
| authorships[2].countries | GB |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I4210143228 |
| authorships[2].affiliations[0].raw_affiliation_string | CRUK Beatson Institute |
| authorships[2].institutions[0].id | https://openalex.org/I4210143228 |
| authorships[2].institutions[0].ror | https://ror.org/03pv69j64 |
| authorships[2].institutions[0].type | facility |
| authorships[2].institutions[0].lineage | https://openalex.org/I2801316944, https://openalex.org/I4210143228 |
| authorships[2].institutions[0].country_code | GB |
| authorships[2].institutions[0].display_name | Cancer Research UK Scotland Institute |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Tamas Yelland |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | CRUK Beatson Institute |
| authorships[3].author.id | https://openalex.org/A5011227935 |
| authorships[3].author.orcid | https://orcid.org/0000-0003-1130-1442 |
| authorships[3].author.display_name | Hannes Ludewig |
| authorships[3].countries | GB |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I16835326 |
| authorships[3].affiliations[0].raw_affiliation_string | Biomedical Sciences Research Complex, University of St Andrews |
| authorships[3].institutions[0].id | https://openalex.org/I16835326 |
| authorships[3].institutions[0].ror | https://ror.org/02wn5qz54 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I16835326 |
| authorships[3].institutions[0].country_code | GB |
| authorships[3].institutions[0].display_name | University of St Andrews |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Hannes Ludewig |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Biomedical Sciences Research Complex, University of St Andrews |
| authorships[4].author.id | https://openalex.org/A5038518295 |
| authorships[4].author.orcid | |
| authorships[4].author.display_name | Robert M. Hagan |
| authorships[4].countries | GB |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I16835326 |
| authorships[4].affiliations[0].raw_affiliation_string | Biomedical Sciences Research Complex, University of St Andrews |
| authorships[4].institutions[0].id | https://openalex.org/I16835326 |
| authorships[4].institutions[0].ror | https://ror.org/02wn5qz54 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I16835326 |
| authorships[4].institutions[0].country_code | GB |
| authorships[4].institutions[0].display_name | University of St Andrews |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Robert M Hagan |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Biomedical Sciences Research Complex, University of St Andrews |
| authorships[5].author.id | https://openalex.org/A5112144750 |
| authorships[5].author.orcid | |
| authorships[5].author.display_name | George Watt |
| authorships[5].countries | GB |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I16835326 |
| authorships[5].affiliations[0].raw_affiliation_string | Biomedical Sciences Research Complex, University of St Andrews |
| authorships[5].institutions[0].id | https://openalex.org/I16835326 |
| authorships[5].institutions[0].ror | https://ror.org/02wn5qz54 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I16835326 |
| authorships[5].institutions[0].country_code | GB |
| authorships[5].institutions[0].display_name | University of St Andrews |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Grant Watt |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Biomedical Sciences Research Complex, University of St Andrews |
| authorships[6].author.id | https://openalex.org/A5025470726 |
| authorships[6].author.orcid | |
| authorships[6].author.display_name | Samir W. Hamaia |
| authorships[6].countries | GB |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I241749 |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Biochemistry, University of Cambridge |
| authorships[6].institutions[0].id | https://openalex.org/I241749 |
| authorships[6].institutions[0].ror | https://ror.org/013meh722 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I241749 |
| authorships[6].institutions[0].country_code | GB |
| authorships[6].institutions[0].display_name | University of Cambridge |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Samir W Hamaia |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Department of Biochemistry, University of Cambridge |
| authorships[7].author.id | https://openalex.org/A5086257480 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-4837-3389 |
| authorships[7].author.display_name | Dominique Bihan |
| authorships[7].countries | GB |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I241749 |
| authorships[7].affiliations[0].raw_affiliation_string | Department of Biochemistry, University of Cambridge |
| authorships[7].institutions[0].id | https://openalex.org/I241749 |
| authorships[7].institutions[0].ror | https://ror.org/013meh722 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I241749 |
| authorships[7].institutions[0].country_code | GB |
| authorships[7].institutions[0].display_name | University of Cambridge |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Dominique Bihan |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Department of Biochemistry, University of Cambridge |
| authorships[8].author.id | https://openalex.org/A5043009093 |
| authorships[8].author.orcid | https://orcid.org/0000-0003-4208-1294 |
| authorships[8].author.display_name | Jean‐Daniel Malcor |
| authorships[8].countries | GB |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I241749 |
| authorships[8].affiliations[0].raw_affiliation_string | Department of Biochemistry, University of Cambridge |
| authorships[8].institutions[0].id | https://openalex.org/I241749 |
| authorships[8].institutions[0].ror | https://ror.org/013meh722 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I241749 |
| authorships[8].institutions[0].country_code | GB |
| authorships[8].institutions[0].display_name | University of Cambridge |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Jean-Daniel Malcor |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Department of Biochemistry, University of Cambridge |
| authorships[9].author.id | https://openalex.org/A5057515518 |
| authorships[9].author.orcid | https://orcid.org/0000-0002-3957-7849 |
| authorships[9].author.display_name | Arkadiusz Bonna |
| authorships[9].countries | GB |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I241749 |
| authorships[9].affiliations[0].raw_affiliation_string | Department of Biochemistry, University of Cambridge |
| authorships[9].institutions[0].id | https://openalex.org/I241749 |
| authorships[9].institutions[0].ror | https://ror.org/013meh722 |
| authorships[9].institutions[0].type | education |
| authorships[9].institutions[0].lineage | https://openalex.org/I241749 |
| authorships[9].institutions[0].country_code | GB |
| authorships[9].institutions[0].display_name | University of Cambridge |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Arkadiusz Bonna |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Department of Biochemistry, University of Cambridge |
| authorships[10].author.id | https://openalex.org/A5031937176 |
| authorships[10].author.orcid | https://orcid.org/0000-0002-5094-1883 |
| authorships[10].author.display_name | Helena Bergsten |
| authorships[10].countries | SE |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I1335113835 |
| authorships[10].affiliations[0].raw_affiliation_string | Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge |
| authorships[10].institutions[0].id | https://openalex.org/I1335113835 |
| authorships[10].institutions[0].ror | https://ror.org/00m8d6786 |
| authorships[10].institutions[0].type | healthcare |
| authorships[10].institutions[0].lineage | https://openalex.org/I1335113835 |
| authorships[10].institutions[0].country_code | SE |
| authorships[10].institutions[0].display_name | Karolinska University Hospital |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Helena Bergsten |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge |
| authorships[11].author.id | https://openalex.org/A5103237050 |
| authorships[11].author.orcid | https://orcid.org/0000-0003-1695-7934 |
| authorships[11].author.display_name | Mattias Svensson |
| authorships[11].countries | SE |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I1335113835 |
| authorships[11].affiliations[0].raw_affiliation_string | Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge |
| authorships[11].institutions[0].id | https://openalex.org/I1335113835 |
| authorships[11].institutions[0].ror | https://ror.org/00m8d6786 |
| authorships[11].institutions[0].type | healthcare |
| authorships[11].institutions[0].lineage | https://openalex.org/I1335113835 |
| authorships[11].institutions[0].country_code | SE |
| authorships[11].institutions[0].display_name | Karolinska University Hospital |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Mattias Svensson |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge |
| authorships[12].author.id | https://openalex.org/A5076094296 |
| authorships[12].author.orcid | https://orcid.org/0000-0002-9665-218X |
| authorships[12].author.display_name | Oddvar Oppegaard |
| authorships[12].countries | NO |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I2800740805, https://openalex.org/I4432739 |
| authorships[12].affiliations[0].raw_affiliation_string | Department of Medicine, Haukeland University Hospital and Department of Clinical Science, University of Bergen |
| authorships[12].institutions[0].id | https://openalex.org/I2800740805 |
| authorships[12].institutions[0].ror | https://ror.org/03np4e098 |
| authorships[12].institutions[0].type | healthcare |
| authorships[12].institutions[0].lineage | https://openalex.org/I2800740805 |
| authorships[12].institutions[0].country_code | NO |
| authorships[12].institutions[0].display_name | Haukeland University Hospital |
| authorships[12].institutions[1].id | https://openalex.org/I4432739 |
| authorships[12].institutions[1].ror | https://ror.org/03zga2b32 |
| authorships[12].institutions[1].type | education |
| authorships[12].institutions[1].lineage | https://openalex.org/I4432739 |
| authorships[12].institutions[1].country_code | NO |
| authorships[12].institutions[1].display_name | University of Bergen |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Oddvar Oppegaard |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | Department of Medicine, Haukeland University Hospital and Department of Clinical Science, University of Bergen |
| authorships[13].author.id | https://openalex.org/A5012930529 |
| authorships[13].author.orcid | https://orcid.org/0000-0003-1615-4453 |
| authorships[13].author.display_name | Steinar Skrede |
| authorships[13].countries | NO |
| authorships[13].affiliations[0].institution_ids | https://openalex.org/I2800740805, https://openalex.org/I4432739 |
| authorships[13].affiliations[0].raw_affiliation_string | Department of Medicine, Haukeland University Hospital and Department of Clinical Science, University of Bergen |
| authorships[13].institutions[0].id | https://openalex.org/I2800740805 |
| authorships[13].institutions[0].ror | https://ror.org/03np4e098 |
| authorships[13].institutions[0].type | healthcare |
| authorships[13].institutions[0].lineage | https://openalex.org/I2800740805 |
| authorships[13].institutions[0].country_code | NO |
| authorships[13].institutions[0].display_name | Haukeland University Hospital |
| authorships[13].institutions[1].id | https://openalex.org/I4432739 |
| authorships[13].institutions[1].ror | https://ror.org/03zga2b32 |
| authorships[13].institutions[1].type | education |
| authorships[13].institutions[1].lineage | https://openalex.org/I4432739 |
| authorships[13].institutions[1].country_code | NO |
| authorships[13].institutions[1].display_name | University of Bergen |
| authorships[13].author_position | middle |
| authorships[13].raw_author_name | Steinar Skrede |
| authorships[13].is_corresponding | False |
| authorships[13].raw_affiliation_strings | Department of Medicine, Haukeland University Hospital and Department of Clinical Science, University of Bergen |
| authorships[14].author.id | https://openalex.org/A5034760490 |
| authorships[14].author.orcid | https://orcid.org/0000-0003-0140-4915 |
| authorships[14].author.display_name | Per Arnell |
| authorships[14].countries | SE |
| authorships[14].affiliations[0].institution_ids | https://openalex.org/I2801112325 |
| authorships[14].affiliations[0].raw_affiliation_string | Department of Anaesthesiology and Intensive Care Medicine, Sahlgrenska University Hospital |
| authorships[14].institutions[0].id | https://openalex.org/I2801112325 |
| authorships[14].institutions[0].ror | https://ror.org/04vgqjj36 |
| authorships[14].institutions[0].type | healthcare |
| authorships[14].institutions[0].lineage | https://openalex.org/I2801112325 |
| authorships[14].institutions[0].country_code | SE |
| authorships[14].institutions[0].display_name | Sahlgrenska University Hospital |
| authorships[14].author_position | middle |
| authorships[14].raw_author_name | Per Arnell |
| authorships[14].is_corresponding | False |
| authorships[14].raw_affiliation_strings | Department of Anaesthesiology and Intensive Care Medicine, Sahlgrenska University Hospital |
| authorships[15].author.id | https://openalex.org/A5032179507 |
| authorships[15].author.orcid | https://orcid.org/0000-0002-1147-379X |
| authorships[15].author.display_name | Ole Hyldegaard |
| authorships[15].countries | DK |
| authorships[15].affiliations[0].institution_ids | https://openalex.org/I124055696, https://openalex.org/I2802567020, https://openalex.org/I2802709434 |
| authorships[15].affiliations[0].raw_affiliation_string | Department of Anaesthesiology, Hyperbaric Medicine Center, Head and Orthopedic Center, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark and Department of Clinical Medicine, University of Copenhagen |
| authorships[15].institutions[0].id | https://openalex.org/I2802567020 |
| authorships[15].institutions[0].ror | https://ror.org/05bpbnx46 |
| authorships[15].institutions[0].type | healthcare |
| authorships[15].institutions[0].lineage | https://openalex.org/I2802567020 |
| authorships[15].institutions[0].country_code | DK |
| authorships[15].institutions[0].display_name | Copenhagen University Hospital |
| authorships[15].institutions[1].id | https://openalex.org/I2802709434 |
| authorships[15].institutions[1].ror | https://ror.org/03mchdq19 |
| authorships[15].institutions[1].type | healthcare |
| authorships[15].institutions[1].lineage | https://openalex.org/I2802567020, https://openalex.org/I2802709434, https://openalex.org/I4210145385 |
| authorships[15].institutions[1].country_code | DK |
| authorships[15].institutions[1].display_name | Rigshospitalet |
| authorships[15].institutions[2].id | https://openalex.org/I124055696 |
| authorships[15].institutions[2].ror | https://ror.org/035b05819 |
| authorships[15].institutions[2].type | education |
| authorships[15].institutions[2].lineage | https://openalex.org/I124055696 |
| authorships[15].institutions[2].country_code | DK |
| authorships[15].institutions[2].display_name | University of Copenhagen |
| authorships[15].author_position | middle |
| authorships[15].raw_author_name | Ole Hyldegaard |
| authorships[15].is_corresponding | False |
| authorships[15].raw_affiliation_strings | Department of Anaesthesiology, Hyperbaric Medicine Center, Head and Orthopedic Center, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark and Department of Clinical Medicine, University of Copenhagen |
| authorships[16].author.id | https://openalex.org/A5074848089 |
| authorships[16].author.orcid | https://orcid.org/0000-0001-6130-8808 |
| authorships[16].author.display_name | Richard W. Farndale |
| authorships[16].countries | GB |
| authorships[16].affiliations[0].institution_ids | https://openalex.org/I241749 |
| authorships[16].affiliations[0].raw_affiliation_string | Department of Biochemistry, University of Cambridge |
| authorships[16].institutions[0].id | https://openalex.org/I241749 |
| authorships[16].institutions[0].ror | https://ror.org/013meh722 |
| authorships[16].institutions[0].type | education |
| authorships[16].institutions[0].lineage | https://openalex.org/I241749 |
| authorships[16].institutions[0].country_code | GB |
| authorships[16].institutions[0].display_name | University of Cambridge |
| authorships[16].author_position | middle |
| authorships[16].raw_author_name | Richard W Farndale |
| authorships[16].is_corresponding | False |
| authorships[16].raw_affiliation_strings | Department of Biochemistry, University of Cambridge |
| authorships[17].author.id | https://openalex.org/A5080532498 |
| authorships[17].author.orcid | https://orcid.org/0000-0001-9372-1795 |
| authorships[17].author.display_name | Anna Norrby‐Teglund |
| authorships[17].countries | SE |
| authorships[17].affiliations[0].institution_ids | https://openalex.org/I1335113835 |
| authorships[17].affiliations[0].raw_affiliation_string | Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge |
| authorships[17].institutions[0].id | https://openalex.org/I1335113835 |
| authorships[17].institutions[0].ror | https://ror.org/00m8d6786 |
| authorships[17].institutions[0].type | healthcare |
| authorships[17].institutions[0].lineage | https://openalex.org/I1335113835 |
| authorships[17].institutions[0].country_code | SE |
| authorships[17].institutions[0].display_name | Karolinska University Hospital |
| authorships[17].author_position | middle |
| authorships[17].raw_author_name | Anna Norrby-Teglund |
| authorships[17].is_corresponding | False |
| authorships[17].raw_affiliation_strings | Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge |
| authorships[18].author.id | https://openalex.org/A5072685344 |
| authorships[18].author.orcid | https://orcid.org/0000-0003-0526-223X |
| authorships[18].author.display_name | Ulrich Schwarz‐Linek |
| authorships[18].countries | GB |
| authorships[18].affiliations[0].institution_ids | https://openalex.org/I16835326 |
| authorships[18].affiliations[0].raw_affiliation_string | Biomedical Sciences Research Complex, University of St Andrews |
| authorships[18].institutions[0].id | https://openalex.org/I16835326 |
| authorships[18].institutions[0].ror | https://ror.org/02wn5qz54 |
| authorships[18].institutions[0].type | education |
| authorships[18].institutions[0].lineage | https://openalex.org/I16835326 |
| authorships[18].institutions[0].country_code | GB |
| authorships[18].institutions[0].display_name | University of St Andrews |
| authorships[18].author_position | last |
| authorships[18].raw_author_name | Ulrich Schwarz-Linek |
| authorships[18].is_corresponding | False |
| authorships[18].raw_affiliation_strings | Biomedical Sciences Research Complex, University of St Andrews |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://doi.org/10.7554/elife.105539.1 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Structural basis for collagen recognition by the Streptococcus pyogenes M3 protein and its involvement in biofilm |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-25T14:43:58.451035 |
| primary_topic.id | https://openalex.org/T11153 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 1.0 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2739 |
| primary_topic.subfield.display_name | Public Health, Environmental and Occupational Health |
| primary_topic.display_name | Streptococcal Infections and Treatments |
| related_works | https://openalex.org/W4396580402, https://openalex.org/W2896567050, https://openalex.org/W1641596209, https://openalex.org/W2091185511, https://openalex.org/W3131527100, https://openalex.org/W2336024593, https://openalex.org/W4388202013, https://openalex.org/W2911275491, https://openalex.org/W3133938346, https://openalex.org/W3180304755 |
| cited_by_count | 1 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 1 |
| locations_count | 1 |
| best_oa_location.id | doi:10.7554/elife.105539.1 |
| best_oa_location.is_oa | True |
| best_oa_location.source | |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | |
| best_oa_location.version | acceptedVersion |
| best_oa_location.raw_type | posted-content |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | False |
| best_oa_location.raw_source_name | |
| best_oa_location.landing_page_url | https://doi.org/10.7554/elife.105539.1 |
| primary_location.id | doi:10.7554/elife.105539.1 |
| primary_location.is_oa | True |
| primary_location.source | |
| primary_location.license | cc-by |
| primary_location.pdf_url | |
| primary_location.version | acceptedVersion |
| primary_location.raw_type | posted-content |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | False |
| primary_location.raw_source_name | |
| primary_location.landing_page_url | https://doi.org/10.7554/elife.105539.1 |
| publication_date | 2025-03-12 |
| publication_year | 2025 |
| referenced_works | https://openalex.org/W4323669754, https://openalex.org/W2171780167, https://openalex.org/W2115748395, https://openalex.org/W4317686272, https://openalex.org/W2081550727, https://openalex.org/W2162247277, https://openalex.org/W2145736155, https://openalex.org/W2043875489, https://openalex.org/W2141541463, https://openalex.org/W2103458678, https://openalex.org/W2079105039, https://openalex.org/W2066557507, https://openalex.org/W2477195065, https://openalex.org/W2512144974, https://openalex.org/W2030200046, https://openalex.org/W1543474898, https://openalex.org/W4213345389, https://openalex.org/W2462129657, https://openalex.org/W2107963892, https://openalex.org/W2999475560, https://openalex.org/W2117498485, https://openalex.org/W2022027892, https://openalex.org/W2147115561, https://openalex.org/W1881544354, https://openalex.org/W2060993096, https://openalex.org/W1999965330, https://openalex.org/W2099055520, https://openalex.org/W1979783118, https://openalex.org/W2959359783, https://openalex.org/W4229594555, https://openalex.org/W2019376311, https://openalex.org/W1993758713, https://openalex.org/W2040437764, https://openalex.org/W2132616675, https://openalex.org/W4395069207, https://openalex.org/W2097910973, https://openalex.org/W3129079010, https://openalex.org/W2111457654, https://openalex.org/W2158181018, https://openalex.org/W1995541867, https://openalex.org/W2062038668, https://openalex.org/W2154513381, https://openalex.org/W2129508689, https://openalex.org/W2160075959, https://openalex.org/W2040479916, https://openalex.org/W1991612575, https://openalex.org/W2032571358, https://openalex.org/W4309858927, https://openalex.org/W4396721167, https://openalex.org/W2017105523, https://openalex.org/W3197410080, https://openalex.org/W2178114386, https://openalex.org/W2799660885, https://openalex.org/W2072433694, https://openalex.org/W4402970390, https://openalex.org/W4399878750, https://openalex.org/W4212971541, https://openalex.org/W2028561215, https://openalex.org/W2072507746, https://openalex.org/W2072008893, https://openalex.org/W2169821755, https://openalex.org/W2169707043, https://openalex.org/W2163341755, https://openalex.org/W2124026197, https://openalex.org/W2159211495, https://openalex.org/W2154714625, https://openalex.org/W2143340646, https://openalex.org/W2149143432, https://openalex.org/W2068206952 |
| referenced_works_count | 69 |
| abstract_inverted_index.A | 14 |
| abstract_inverted_index.M | 2, 31 |
| abstract_inverted_index.a | 101, 111 |
| abstract_inverted_index.In | 161 |
| abstract_inverted_index.M3 | 50, 74, 90, 191 |
| abstract_inverted_index.an | 5, 179, 200, 240 |
| abstract_inverted_index.as | 96, 98, 143 |
| abstract_inverted_index.be | 186 |
| abstract_inverted_index.by | 54 |
| abstract_inverted_index.in | 92, 178, 209, 228 |
| abstract_inverted_index.is | 4, 40, 52, 61, 226 |
| abstract_inverted_index.of | 9, 18, 30, 73, 87, 124, 130, 158, 175, 250 |
| abstract_inverted_index.or | 12 |
| abstract_inverted_index.to | 100, 155, 205 |
| abstract_inverted_index.we | 69, 165 |
| abstract_inverted_index.GAS | 58, 138, 177, 220 |
| abstract_inverted_index.The | 1, 49, 128 |
| abstract_inverted_index.and | 22, 27, 34, 46, 81, 139, 257 |
| abstract_inverted_index.are | 203, 222 |
| abstract_inverted_index.but | 198 |
| abstract_inverted_index.can | 152, 185 |
| abstract_inverted_index.emm | 180 |
| abstract_inverted_index.for | 42, 247, 254 |
| abstract_inverted_index.how | 136 |
| abstract_inverted_index.not | 199 |
| abstract_inverted_index.one | 17 |
| abstract_inverted_index.the | 19, 55, 71, 88, 93, 106, 121, 131, 144, 168, 189, 248 |
| abstract_inverted_index.GAS, | 197 |
| abstract_inverted_index.Here | 68 |
| abstract_inverted_index.This | 224 |
| abstract_inverted_index.data | 234 |
| abstract_inverted_index.emm1 | 201 |
| abstract_inverted_index.emm3 | 57, 137, 176, 196 |
| abstract_inverted_index.fold | 115 |
| abstract_inverted_index.free | 94 |
| abstract_inverted_index.from | 105, 212 |
| abstract_inverted_index.host | 38 |
| abstract_inverted_index.into | 239 |
| abstract_inverted_index.line | 162 |
| abstract_inverted_index.most | 20 |
| abstract_inverted_index.skin | 230 |
| abstract_inverted_index.soft | 216 |
| abstract_inverted_index.such | 142 |
| abstract_inverted_index.that | 116, 167 |
| abstract_inverted_index.type | 181 |
| abstract_inverted_index.well | 97 |
| abstract_inverted_index.with | 37, 64, 75, 163, 188, 207, 214, 245 |
| abstract_inverted_index.based | 259 |
| abstract_inverted_index.bound | 99 |
| abstract_inverted_index.group | 13 |
| abstract_inverted_index.human | 24, 76, 146 |
| abstract_inverted_index.novel | 112 |
| abstract_inverted_index.shown | 204 |
| abstract_inverted_index.sites | 119 |
| abstract_inverted_index.state | 95 |
| abstract_inverted_index.their | 35 |
| abstract_inverted_index.these | 233 |
| abstract_inverted_index.this, | 164 |
| abstract_inverted_index.where | 219 |
| abstract_inverted_index.which | 60, 184 |
| abstract_inverted_index.(GAS), | 16 |
| abstract_inverted_index.common | 21 |
| abstract_inverted_index.domain | 91, 193 |
| abstract_inverted_index.enable | 156 |
| abstract_inverted_index.factor | 8 |
| abstract_inverted_index.reveal | 110 |
| abstract_inverted_index.severe | 65 |
| abstract_inverted_index.subsp. | 150 |
| abstract_inverted_index.target | 153 |
| abstract_inverted_index.tissue | 210, 217 |
| abstract_inverted_index.triple | 126 |
| abstract_inverted_index.Ligands | 108 |
| abstract_inverted_index.binding | 83, 118 |
| abstract_inverted_index.biofilm | 173, 256 |
| abstract_inverted_index.common. | 223 |
| abstract_inverted_index.complex | 134 |
| abstract_inverted_index.crucial | 41 |
| abstract_inverted_index.derived | 104 |
| abstract_inverted_index.design. | 261 |
| abstract_inverted_index.manner, | 183 |
| abstract_inverted_index.models. | 231 |
| abstract_inverted_index.peptide | 103, 133 |
| abstract_inverted_index.protein | 3, 32, 51, 114 |
| abstract_inverted_index.provide | 235 |
| abstract_inverted_index.related | 140 |
| abstract_inverted_index.strain, | 202 |
| abstract_inverted_index.through | 78 |
| abstract_inverted_index.vaccine | 47, 260 |
| abstract_inverted_index.various | 159 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.Collagen | 107 |
| abstract_inverted_index.Further, | 195 |
| abstract_inverted_index.T-shaped | 113 |
| abstract_inverted_index.biofilms | 221 |
| abstract_inverted_index.biopsies | 211 |
| abstract_inverted_index.collagen | 102, 125, 208 |
| abstract_inverted_index.detailed | 79, 236 |
| abstract_inverted_index.emerging | 145 |
| abstract_inverted_index.enhanced | 172 |
| abstract_inverted_index.explains | 135 |
| abstract_inverted_index.helices. | 127 |
| abstract_inverted_index.insights | 238 |
| abstract_inverted_index.invasive | 66, 251 |
| abstract_inverted_index.pathogen | 147 |
| abstract_inverted_index.patients | 213 |
| abstract_inverted_index.presents | 117 |
| abstract_inverted_index.produced | 53 |
| abstract_inverted_index.promotes | 171 |
| abstract_inverted_index.specific | 182 |
| abstract_inverted_index.tissues. | 160 |
| abstract_inverted_index.topology | 123 |
| abstract_inverted_index.treating | 255 |
| abstract_inverted_index.variants | 33 |
| abstract_inverted_index.M-protein | 258 |
| abstract_inverted_index.Molecular | 26 |
| abstract_inverted_index.Together, | 232 |
| abstract_inverted_index.analysis. | 84 |
| abstract_inverted_index.collagens | 77, 154 |
| abstract_inverted_index.dangerous | 23 |
| abstract_inverted_index.diseases. | 67 |
| abstract_inverted_index.essential | 6 |
| abstract_inverted_index.formation | 174 |
| abstract_inverted_index.fragment. | 194 |
| abstract_inverted_index.important | 241 |
| abstract_inverted_index.inhibited | 187 |
| abstract_inverted_index.mechanism | 244 |
| abstract_inverted_index.molecular | 237 |
| abstract_inverted_index.prevalent | 56 |
| abstract_inverted_index.pyogenes, | 11 |
| abstract_inverted_index.serotype, | 59 |
| abstract_inverted_index.structure | 129 |
| abstract_inverted_index.virulence | 7, 243 |
| abstract_inverted_index.Collection | 109 |
| abstract_inverted_index.N-terminal | 89, 192 |
| abstract_inverted_index.associated | 63 |
| abstract_inverted_index.colocalize | 206 |
| abstract_inverted_index.components | 39 |
| abstract_inverted_index.frequently | 62 |
| abstract_inverted_index.functional | 28 |
| abstract_inverted_index.pathogens. | 25 |
| abstract_inverted_index.reproduced | 227 |
| abstract_inverted_index.strategies | 253 |
| abstract_inverted_index.structural | 80 |
| abstract_inverted_index.structures | 86 |
| abstract_inverted_index.M3/collagen | 132, 169 |
| abstract_inverted_index.biochemical | 82 |
| abstract_inverted_index.demonstrate | 166 |
| abstract_inverted_index.infections, | 218, 252 |
| abstract_inverted_index.interaction | 72, 170 |
| abstract_inverted_index.necrotizing | 215 |
| abstract_inverted_index.observation | 225 |
| abstract_inverted_index.organotypic | 229 |
| abstract_inverted_index.recombinant | 190 |
| abstract_inverted_index.characterize | 70 |
| abstract_inverted_index.colonization | 157 |
| abstract_inverted_index.development. | 48 |
| abstract_inverted_index.dysgalactiae | 149 |
| abstract_inverted_index.equisimilis, | 151 |
| abstract_inverted_index.implications | 246 |
| abstract_inverted_index.interactions | 36 |
| abstract_inverted_index.pathogenesis | 45 |
| abstract_inverted_index.streptococci | 15 |
| abstract_inverted_index.Streptococcus | 10, 148 |
| abstract_inverted_index.complementing | 120 |
| abstract_inverted_index.streptococcal | 44, 242 |
| abstract_inverted_index.streptococci, | 141 |
| abstract_inverted_index.understanding | 43, 249 |
| abstract_inverted_index.characteristic | 122 |
| abstract_inverted_index.High-resolution | 85 |
| abstract_inverted_index.characterization | 29 |
| cited_by_percentile_year.max | 95 |
| cited_by_percentile_year.min | 91 |
| countries_distinct_count | 4 |
| institutions_distinct_count | 19 |
| citation_normalized_percentile.value | 0.86956695 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |