Structural Characterization of Mono- and Dimethylphosphatidylethanolamines from Various Organisms Using a Complex Analytical Strategy including Chiral Chromatography Article Swipe
Tomáš Řezanka
,
Andrea Palyzová
,
Milada Vítová
,
Tomáš Brányik
,
Markéta Kulišová
,
Irena Kolouchová
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/sym14030616
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/sym14030616
Two minor phospholipids, i.e., mono- and/or dimethylphosphatidylethanolamines, are widespread in many organisms, from bacteria to higher plants and animals. A molecular mixture of methyl-PE and dimethyl-PE was obtained from total lipids by liquid chromatography and further identified by mass spectrometry. Total methyl-PE and dimethyl-PE were cleaved by phospholipase C, and the resulting diacylglycerols, in the form of acetyl derivatives, were separated into alkyl-acyl, alkenyl-acyl, and diacylglycerols. Reversed-phase LC/MS allowed dozens of molecular species to be identified and further analyzed. This was performed on a chiral column, and identification by tandem positive ESI revealed that diacyl derivatives from all four bacteria were mixtures of both R and S enantiomers. The same applied to alkenyl-acyl derivatives of anaerobic bacteria. Analysis thus confirmed that some bacteria biosynthesize phospholipids having both sn-glycerol-3-phosphate and sn-glycerol-1-phosphate as precursors. These findings were further supported by data already published in GenBank. The use of chiral chromatography made it possible to prove that both enantiomers of glycerol phosphate of some molecular species of mono- and dimethylphosphatidylethanolamines are present. The result of the analysis can be interpreted that the cultured bacteria do not have homochiral membranes but, on the contrary, have an asymmetric, i.e., heterochiral membranes.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/sym14030616
- https://www.mdpi.com/2073-8994/14/3/616/pdf?version=1648014866
- OA Status
- gold
- Cited By
- 3
- References
- 81
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4221084561
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Raw OpenAlex JSON
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https://openalex.org/W4221084561Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/sym14030616Digital Object Identifier
- Title
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Structural Characterization of Mono- and Dimethylphosphatidylethanolamines from Various Organisms Using a Complex Analytical Strategy including Chiral ChromatographyWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-03-19Full publication date if available
- Authors
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Tomáš Řezanka, Andrea Palyzová, Milada Vítová, Tomáš Brányik, Markéta Kulišová, Irena KolouchováList of authors in order
- Landing page
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https://doi.org/10.3390/sym14030616Publisher landing page
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https://www.mdpi.com/2073-8994/14/3/616/pdf?version=1648014866Direct link to full text PDF
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goldOpen access status per OpenAlex
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https://www.mdpi.com/2073-8994/14/3/616/pdf?version=1648014866Direct OA link when available
- Concepts
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Enantiomer, Bacteria, Chemistry, Glycerol, Chromatography, Phospholipid, Alkyl, Membrane, Tandem mass spectrometry, Mass spectrometry, Organic chemistry, Biochemistry, Biology, GeneticsTop concepts (fields/topics) attached by OpenAlex
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3Total citation count in OpenAlex
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2024: 1, 2023: 2Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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