Structure-based amelioration of PXR transactivation in a novel series of macrocyclic allosteric inhibitors of HIV-1 integrase Article Swipe
Prasanna Sivaprakasam
,
Zhongyu Wang
,
Nicholas A. Meanwell
,
Javed Khan
,
David R. Langley
,
Stephen R. Johnson
,
Li Guo
,
Annapurna Pendri
,
Timothy P. Connolly
,
Mian Gao
,
Daniel M. Camac
,
Cheryl Klakouski
,
Tatyana Zvyaga
,
Christopher Cianci
,
Brian McAuliffe
,
Bo Ding
,
Linda Discotto
,
Mark Krystal
,
Susan Jenkins
,
Kevin M. Peese
,
B. Narasimhulu Naidu
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1016/j.bmcl.2020.127531
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1016/j.bmcl.2020.127531
Related Topics
Concepts
Pregnane X receptor
Transactivation
Chemistry
Allosteric regulation
Stereochemistry
Structure–activity relationship
Cocrystal
Rational design
Molecular model
Nuclear receptor
Pharmacology
Biochemistry
Enzyme
In vitro
Transcription factor
Biology
Molecule
Organic chemistry
Gene
Genetics
Hydrogen bond
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.bmcl.2020.127531
- OA Status
- green
- Cited By
- 7
- References
- 20
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3082710438
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3082710438Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1016/j.bmcl.2020.127531Digital Object Identifier
- Title
-
Structure-based amelioration of PXR transactivation in a novel series of macrocyclic allosteric inhibitors of HIV-1 integraseWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-09-02Full publication date if available
- Authors
-
Prasanna Sivaprakasam, Zhongyu Wang, Nicholas A. Meanwell, Javed Khan, David R. Langley, Stephen R. Johnson, Li Guo, Annapurna Pendri, Timothy P. Connolly, Mian Gao, Daniel M. Camac, Cheryl Klakouski, Tatyana Zvyaga, Christopher Cianci, Brian McAuliffe, Bo Ding, Linda Discotto, Mark Krystal, Susan Jenkins, Kevin M. Peese, B. Narasimhulu NaiduList of authors in order
- Landing page
-
https://doi.org/10.1016/j.bmcl.2020.127531Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.7270/q2db85g5Direct OA link when available
- Concepts
-
Pregnane X receptor, Transactivation, Chemistry, Allosteric regulation, Stereochemistry, Structure–activity relationship, Cocrystal, Rational design, Molecular model, Nuclear receptor, Pharmacology, Biochemistry, Enzyme, In vitro, Transcription factor, Biology, Molecule, Organic chemistry, Gene, Genetics, Hydrogen bondTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
7Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2023: 1, 2022: 4, 2021: 1Per-year citation counts (last 5 years)
- References (count)
-
20Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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