Structure-Function Analysis of the Transmembrane Protein AmpG from Pseudomonas aeruginosa Article Swipe
Peizhen Li
,
Jun Ying
,
Guangjian Yang
,
Aifang Li
,
Jian Wang
,
Junwan Lu
,
Junrong Wang
,
Teng Xu
,
Huiguang Yi
,
Kewei Li
,
Shouguang Jin
,
Qiyu Bao
,
Kaibo Zhang
·
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pone.0168060
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pone.0168060
AmpG is a transmembrane protein with permease activity that transports meuropeptide from the periplasm to the cytoplasm, which is essential for the induction of the ampC encoding β-lactamase. To obtain new insights into the relationship between AmpG structure and function, comparative genomics analysis, secondary and tertiary structure modeling, site-directed mutational analyses and genetic complementation experiments were performed in this study. AmpGs from different genera of bacteria (Escherichia coli, Vibrio cholerae and Acinetobacter baumannii) could complement AmpG function in Pseudomonas aeruginosa. The minimal inhibitory concentration (MIC) to ampicillin is 512 μg/ml for wild type strain PAO1, while it is 32 μg/ml for an ampG deletion mutant strain (PAO1ΔampG) with a corresponding decrease in the activity of the ampC-encoded β-lactamase. Site-directed mutagenesis of conserved AmpG residues (G29, A129, Q131 and A197) resulted in a loss of function, resulting in a loss of resistance to ampicillin in PAO1ΔampG. The G29A, G29V, A129T, A129V, A129D, A197S and A197D mutants had lower resistance to ampicillin and significantly decreased activity of the AmpC β-lactamase. The G29A, G29V, A129V, A197S and A197D mutants had decreased ampG mRNA transcript levels. The A129T and A129D mutants had normal ampG mRNA transcript levels, but the function of the protein was drastically reduced. Our experimental results demonstrate that the conserved amino acids played essential roles in maintaining the function of AmpG. Combined with the AmpG structural information, these critical amino acids can be targeted for the development of new anti-bacterial agents.
Related Topics
Concepts
Periplasmic space
Complementation
Biology
Mutant
Pseudomonas aeruginosa
Vibrio cholerae
Escherichia coli
Mutagenesis
Microbiology
Bacterial outer membrane
Amp resistance
Transmembrane protein
Biochemistry
Genetics
Gene
Bacteria
Receptor
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1371/journal.pone.0168060
- https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0168060&type=printable
- OA Status
- gold
- Cited By
- 14
- References
- 35
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2563221447
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2563221447Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1371/journal.pone.0168060Digital Object Identifier
- Title
-
Structure-Function Analysis of the Transmembrane Protein AmpG from Pseudomonas aeruginosaWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2016Year of publication
- Publication date
-
2016-12-13Full publication date if available
- Authors
-
Peizhen Li, Jun Ying, Guangjian Yang, Aifang Li, Jian Wang, Junwan Lu, Junrong Wang, Teng Xu, Huiguang Yi, Kewei Li, Shouguang Jin, Qiyu Bao, Kaibo ZhangList of authors in order
- Landing page
-
https://doi.org/10.1371/journal.pone.0168060Publisher landing page
- PDF URL
-
https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0168060&type=printableDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0168060&type=printableDirect OA link when available
- Concepts
-
Periplasmic space, Complementation, Biology, Mutant, Pseudomonas aeruginosa, Vibrio cholerae, Escherichia coli, Mutagenesis, Microbiology, Bacterial outer membrane, Amp resistance, Transmembrane protein, Biochemistry, Genetics, Gene, Bacteria, ReceptorTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
14Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 3, 2023: 1, 2022: 3, 2021: 1, 2019: 1Per-year citation counts (last 5 years)
- References (count)
-
35Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.had | 155, 176, 187 |
| abstract_inverted_index.new | 30, 237 |
| abstract_inverted_index.the | 12, 15, 21, 24, 33, 112, 115, 165, 194, 197, 207, 216, 222, 234 |
| abstract_inverted_index.was | 199 |
| abstract_inverted_index.AmpC | 166 |
| abstract_inverted_index.AmpG | 0, 36, 75, 122, 223 |
| abstract_inverted_index.Q131 | 126 |
| abstract_inverted_index.ampC | 25 |
| abstract_inverted_index.ampG | 102, 178, 189 |
| abstract_inverted_index.from | 11, 61 |
| abstract_inverted_index.into | 32 |
| abstract_inverted_index.loss | 132, 138 |
| abstract_inverted_index.mRNA | 179, 190 |
| abstract_inverted_index.that | 8, 206 |
| abstract_inverted_index.this | 58 |
| abstract_inverted_index.type | 92 |
| abstract_inverted_index.were | 55 |
| abstract_inverted_index.wild | 91 |
| abstract_inverted_index.with | 5, 107, 221 |
| abstract_inverted_index.(G29, | 124 |
| abstract_inverted_index.(MIC) | 84 |
| abstract_inverted_index.A129, | 125 |
| abstract_inverted_index.A129D | 185 |
| abstract_inverted_index.A129T | 183 |
| abstract_inverted_index.A197) | 128 |
| abstract_inverted_index.A197D | 153, 174 |
| abstract_inverted_index.A197S | 151, 172 |
| abstract_inverted_index.AmpG. | 219 |
| abstract_inverted_index.AmpGs | 60 |
| abstract_inverted_index.G29A, | 146, 169 |
| abstract_inverted_index.G29V, | 147, 170 |
| abstract_inverted_index.PAO1, | 94 |
| abstract_inverted_index.acids | 210, 229 |
| abstract_inverted_index.amino | 209, 228 |
| abstract_inverted_index.coli, | 67 |
| abstract_inverted_index.could | 73 |
| abstract_inverted_index.lower | 156 |
| abstract_inverted_index.roles | 213 |
| abstract_inverted_index.these | 226 |
| abstract_inverted_index.which | 17 |
| abstract_inverted_index.while | 95 |
| abstract_inverted_index.A129D, | 150 |
| abstract_inverted_index.A129T, | 148 |
| abstract_inverted_index.A129V, | 149, 171 |
| abstract_inverted_index.Vibrio | 68 |
| abstract_inverted_index.genera | 63 |
| abstract_inverted_index.mutant | 104 |
| abstract_inverted_index.normal | 188 |
| abstract_inverted_index.obtain | 29 |
| abstract_inverted_index.played | 211 |
| abstract_inverted_index.strain | 93, 105 |
| abstract_inverted_index.study. | 59 |
| abstract_inverted_index.μg/ml | 89, 99 |
| abstract_inverted_index.agents. | 239 |
| abstract_inverted_index.between | 35 |
| abstract_inverted_index.genetic | 52 |
| abstract_inverted_index.levels, | 192 |
| abstract_inverted_index.levels. | 181 |
| abstract_inverted_index.minimal | 81 |
| abstract_inverted_index.mutants | 154, 175, 186 |
| abstract_inverted_index.protein | 4, 198 |
| abstract_inverted_index.results | 204 |
| abstract_inverted_index.Combined | 220 |
| abstract_inverted_index.activity | 7, 113, 163 |
| abstract_inverted_index.analyses | 50 |
| abstract_inverted_index.bacteria | 65 |
| abstract_inverted_index.cholerae | 69 |
| abstract_inverted_index.critical | 227 |
| abstract_inverted_index.decrease | 110 |
| abstract_inverted_index.deletion | 103 |
| abstract_inverted_index.encoding | 26 |
| abstract_inverted_index.function | 76, 195, 217 |
| abstract_inverted_index.genomics | 41 |
| abstract_inverted_index.insights | 31 |
| abstract_inverted_index.permease | 6 |
| abstract_inverted_index.reduced. | 201 |
| abstract_inverted_index.residues | 123 |
| abstract_inverted_index.resulted | 129 |
| abstract_inverted_index.targeted | 232 |
| abstract_inverted_index.tertiary | 45 |
| abstract_inverted_index.analysis, | 42 |
| abstract_inverted_index.conserved | 121, 208 |
| abstract_inverted_index.decreased | 162, 177 |
| abstract_inverted_index.different | 62 |
| abstract_inverted_index.essential | 19, 212 |
| abstract_inverted_index.function, | 39, 134 |
| abstract_inverted_index.induction | 22 |
| abstract_inverted_index.modeling, | 47 |
| abstract_inverted_index.performed | 56 |
| abstract_inverted_index.periplasm | 13 |
| abstract_inverted_index.resulting | 135 |
| abstract_inverted_index.secondary | 43 |
| abstract_inverted_index.structure | 37, 46 |
| abstract_inverted_index.ampicillin | 86, 142, 159 |
| abstract_inverted_index.baumannii) | 72 |
| abstract_inverted_index.complement | 74 |
| abstract_inverted_index.cytoplasm, | 16 |
| abstract_inverted_index.inhibitory | 82 |
| abstract_inverted_index.mutational | 49 |
| abstract_inverted_index.resistance | 140, 157 |
| abstract_inverted_index.structural | 224 |
| abstract_inverted_index.transcript | 180, 191 |
| abstract_inverted_index.transports | 9 |
| abstract_inverted_index.PAO1ΔampG. | 144 |
| abstract_inverted_index.Pseudomonas | 78 |
| abstract_inverted_index.aeruginosa. | 79 |
| abstract_inverted_index.comparative | 40 |
| abstract_inverted_index.demonstrate | 205 |
| abstract_inverted_index.development | 235 |
| abstract_inverted_index.drastically | 200 |
| abstract_inverted_index.experiments | 54 |
| abstract_inverted_index.maintaining | 215 |
| abstract_inverted_index.mutagenesis | 119 |
| abstract_inverted_index.(Escherichia | 66 |
| abstract_inverted_index.(PAO1ΔampG) | 106 |
| abstract_inverted_index.ampC-encoded | 116 |
| abstract_inverted_index.experimental | 203 |
| abstract_inverted_index.information, | 225 |
| abstract_inverted_index.meuropeptide | 10 |
| abstract_inverted_index.relationship | 34 |
| abstract_inverted_index.Acinetobacter | 71 |
| abstract_inverted_index.Site-directed | 118 |
| abstract_inverted_index.concentration | 83 |
| abstract_inverted_index.corresponding | 109 |
| abstract_inverted_index.significantly | 161 |
| abstract_inverted_index.site-directed | 48 |
| abstract_inverted_index.transmembrane | 3 |
| abstract_inverted_index.β-lactamase. | 27, 117, 167 |
| abstract_inverted_index.anti-bacterial | 238 |
| abstract_inverted_index.complementation | 53 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5087478830, https://openalex.org/A5101943568, https://openalex.org/A5003791054, https://openalex.org/A5040873566, https://openalex.org/A5101953347, https://openalex.org/A5036438615, https://openalex.org/A5087461678, https://openalex.org/A5102006839, https://openalex.org/A5102016185, https://openalex.org/A5100370474, https://openalex.org/A5009099198, https://openalex.org/A5006942289, https://openalex.org/A5101760487 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 13 |
| corresponding_institution_ids | https://openalex.org/I27781120, https://openalex.org/I3129496460, https://openalex.org/I33213144, https://openalex.org/I4210144189 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/15 |
| sustainable_development_goals[0].score | 0.41999998688697815 |
| sustainable_development_goals[0].display_name | Life in Land |
| citation_normalized_percentile.value | 0.71707748 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |