Structure of the Mammalian Mediator Article Swipe

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Haiyan Zhao , Natalie Young , Jens Kalchschmidt , Jenna Ariel Lieberman , Laïla El Khattabi , Rafael Casellas , Francisco J. Asturias ·

YOU? · · 2020 · Open Access · · DOI: https://doi.org/10.1101/2020.10.05.326918

The Mediator complex plays an essential and multi-faceted role in regulation of RNA polymerase II transcription in all eukaryotes. Structural analysis of yeast Mediator has provided an understanding of the conserved core of the complex and its interaction with RNA polymerase II but failed to reveal the structure of the Tail module that contains most subunits targeted by activators and repressors. Here we present a molecular model of mammalian ( Mus musculus ) Mediator, derived from a 4.0 Å resolution cryo-EM map of the complex. The mammalian Mediator structure reveals that the previously unresolved Tail module, which includes a number of metazoan specific subunits, interacts extensively with core Mediator and has the potential to influence its conformation and interactions.

Related Topics

Biology

Cell Biology

Computational Biology

Rna Polymerase

Reverse Transcription Polymerase Chain Reaction

Rna

Gene Expression

Philosophy

Concepts

Mediator RNA polymerase II Biology Transcription (linguistics) Cell biology Computational biology Protein subunit RNA polymerase Repressor Polymerase Genetics RNA Transcription factor Gene Promoter Gene expression Philosophy Linguistics

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Type: preprint
Language: en
Landing Page: https://doi.org/10.1101/2020.10.05.326918
PDF: https://www.biorxiv.org/content/biorxiv/early/2020/10/06/2020.10.05.326918.full.pdf
OA Status: green
Cited By: 1
References: 34
Related Works: 10
OpenAlex ID: https://openalex.org/W3092633424

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DOI: https://doi.org/10.1101/2020.10.05.326918

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Title: Structure of the Mammalian Mediator

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Type: preprint

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Language: en

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Publication year: 2020

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Publication date: 2020-10-06

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Authors: Haiyan Zhao, Natalie Young, Jens Kalchschmidt, Jenna Ariel Lieberman, Laïla El Khattabi, Rafael Casellas, Francisco J. Asturias

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Landing page: https://doi.org/10.1101/2020.10.05.326918

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Concepts: Mediator, RNA polymerase II, Biology, Transcription (linguistics), Cell biology, Computational biology, Protein subunit, RNA polymerase, Repressor, Polymerase, Genetics, RNA, Transcription factor, Gene, Promoter, Gene expression, Philosophy, Linguistics

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Cited by: 1

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