Structure–Activity Relationship of Synthetic Cathinones: An Updated Review Article Swipe
Núria Nadal‐Gratacós
,
Martalu D. Pazos
,
David Pubill
,
Jorge Camarasa
,
Elena Escubedo
,
Xavier Berzosa
,
Raúl López‐Arnau
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1021/acsptsci.4c00299
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1021/acsptsci.4c00299
The escalating prevalence of new psychoactive substances (NPSs) poses a significant public health challenge, evidenced by the vast chemical diversity, with over 500 substances reported annually to the United Nations Office on Drugs and Crime-Early Warning Advisory (UNODC-EWA) in the past five years. Among NPSs, synthetic cathinones are gaining a lot of popularity among users. Notably, synthetic cathinones accounted for approximately 50% of the total quantity of NPSs reported as seized by EU Member States in 2021. Preliminary data from UNODC indicates that a total of 209 synthetic cathinones have been reported to date. As their popularity grows, studying the structure-activity relationship (SAR) of synthetic cathinones is essential. SAR studies elucidate how structural features impact biological effects, aiding in toxicity prediction, regulatory compliance, and forensic identification. Additionally, SAR studies play a pivotal role in guiding drug policies, aiding authorities in categorizing and regulating newly emerging synthetic cathinones, mitigate public health risks and offer valuable insights into potential therapeutic applications. Thus, our Review consolidates recent findings on the effects of different substitutions in the chemical scaffold of synthetic cathinones on their mechanism of action as well as pharmacological and toxicological effects of synthetic cathinones, thus enhancing understanding of the SAR of synthetic cathinones' pharmacology and potential implications.
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- Type
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- Language
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- Landing Page
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- OA Status
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https://doi.org/10.1021/acsptsci.4c00299Digital Object Identifier
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Structure–Activity Relationship of Synthetic Cathinones: An Updated ReviewWork title
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enPrimary language
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2024Year of publication
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2024-08-06Full publication date if available
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Núria Nadal‐Gratacós, Martalu D. Pazos, David Pubill, Jorge Camarasa, Elena Escubedo, Xavier Berzosa, Raúl López‐ArnauList of authors in order
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https://doi.org/10.1021/acsptsci.4c00299Publisher landing page
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://doi.org/10.1021/acsptsci.4c00299Direct OA link when available
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Popularity, Business, Political science, LawTop concepts (fields/topics) attached by OpenAlex
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