Study on the significance correlation between CEBPA and Calreticulin at mRNA level diagnosed in de nevo AML patients Article Swipe
Fatemeh Salarpour
,
Kourosh Goudarzipour
,
Mohammad Hossein Mohammadi
,
Abbas Hajifathali
,
Mehdi Allahbakhshian Farsani
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3329/bjms.v19i4.46633
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3329/bjms.v19i4.46633
Objectives: Calreticulin (CALR) and CCAAT/enhancer binding protein (C/EBP) alpha (CEBPA) are two important multifunctional proteins which play different roles in regulation of hematopoiesis. Expressional changes of these genes were related to the malignancy. Methods: The present study aimed to investigate the expression levels of CALR and CEBPA genes in 96 de novo AML patients compared to 18 normal people as the control group through the Real-Time-PCR. Results: Results of the present study revealed that the expression of these genes was significantly higher in patients with AML than the normal group (P <0.0001). Furthermore, there was a significant and positive correlation between CALR and CEBPA (P= 0.001 and r= 0.348). Discussion: Higher level of CALR expression was expected, but the overexpression of CEBPA was on the contrary to its well-known role in the myeloid maturation. Based on the studies, CALR probably played roles in the expression of oncogenic CEBPA and it repressed the CEBPA translation in tumor suppressor gene (TSG). Conclusion: The present study first indicated the over-expression of CALR in AML patients and compared it with the healthy normal control group and also found a positive relationship between CALR and CEBPA expression in the AML patients. Bangladesh Journal of Medical Science Vol.19(4) 2020 p.730-736
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3329/bjms.v19i4.46633
- https://www.banglajol.info/index.php/BJMS/article/download/46633/34102
- OA Status
- diamond
- Cited By
- 3
- References
- 24
- Related Works
- 10
- OpenAlex ID
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3017017164Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3329/bjms.v19i4.46633Digital Object Identifier
- Title
-
Study on the significance correlation between CEBPA and Calreticulin at mRNA level diagnosed in de nevo AML patientsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
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2020-04-12Full publication date if available
- Authors
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Fatemeh Salarpour, Kourosh Goudarzipour, Mohammad Hossein Mohammadi, Abbas Hajifathali, Mehdi Allahbakhshian FarsaniList of authors in order
- Landing page
-
https://doi.org/10.3329/bjms.v19i4.46633Publisher landing page
- PDF URL
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https://www.banglajol.info/index.php/BJMS/article/download/46633/34102Direct link to full text PDF
- Open access
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YesWhether a free full text is available
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diamondOpen access status per OpenAlex
- OA URL
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https://www.banglajol.info/index.php/BJMS/article/download/46633/34102Direct OA link when available
- Concepts
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CEBPA, Calreticulin, Medicine, Gene, Myeloid leukemia, Cancer research, Messenger RNA, Internal medicine, Oncology, Biology, Genetics, Endoplasmic reticulum, Transcription factorTop concepts (fields/topics) attached by OpenAlex
- Cited by
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3Total citation count in OpenAlex
- Citations by year (recent)
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2025: 2, 2024: 1Per-year citation counts (last 5 years)
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24Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| referenced_works | https://openalex.org/W6644035497, https://openalex.org/W1992604276, https://openalex.org/W2142541925, https://openalex.org/W2057733834, https://openalex.org/W2002374697, https://openalex.org/W7074036461, https://openalex.org/W2054693693, https://openalex.org/W2160883482, https://openalex.org/W1975905680, https://openalex.org/W2081773938, https://openalex.org/W2191486239, https://openalex.org/W2081580118, https://openalex.org/W2756171353, https://openalex.org/W2086915316, https://openalex.org/W2029422337, https://openalex.org/W2888939981, https://openalex.org/W2057572797, https://openalex.org/W1573959016, https://openalex.org/W2470037465, https://openalex.org/W1995145790, https://openalex.org/W1974734211, https://openalex.org/W2065582394, https://openalex.org/W2114570899, https://openalex.org/W2052464502 |
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