Study protocol: randomised controlled trial evaluating exercise therapy as a supplemental treatment strategy in early multiple sclerosis: the Early Multiple Sclerosis Exercise Study (EMSES) Article Swipe
Morten Riemenschneider
,
Lars G. Hvid
,
Steffen Ringgaard
,
Mikkel Nygaard
,
Simon Fristed Eskildsen
,
Thor Petersen
,
Egon Stenager
,
Ulrik Dalgas
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1136/bmjopen-2020-043699
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1136/bmjopen-2020-043699
Introduction In the relapsing remitting type of multiple sclerosis (MS) reducing relapses and neurodegeneration is crucial in halting the long-term impact of the disease. Medical disease-modifying treatments have proven effective, especially when introduced early in the disease course. However, patients still experience disease activity and disability progression, and therefore, supplemental early treatment strategies are warranted. Exercise appear to be one of the most promising supplemental treatment strategies, but a somewhat overlooked ‘window of opportunity’ exist early in the disease course. The objective of this study is to investigate exercise as a supplementary treatment strategy early in the disease course of MS. Methods and analysis The presented Early Multiple Sclerosis Exercise Study is a 48-week (plus 1-year follow-up) national multicentre single-blinded parallel group randomised controlled trial comparing two groups receiving usual care plus supervised high-intense exercise or plus health education (active control). Additionally, data will be compared with a population-based control group receiving usual care only obtained from the Danish MS Registry. The primary outcomes are annual relapse rate and MRI derived global brain atrophy. The secondary outcomes are disability progression, physical and cognitive function, MS-related symptoms, and exploratory MRI outcomes. All analyses will be performed as intention to treat. Ethics and dissemination The study is approved by The Central Denmark Region Committees on Health Research Ethics (1-10-72-388-17) and registered at the Danish Data Protection Agency (2016-051-000001 (706)). All study findings will be published in scientific peer-reviewed journals and presented at relevant scientific conferences. Trial registration number NCT03322761 .
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1136/bmjopen-2020-043699
- https://bmjopen.bmj.com/content/bmjopen/11/1/e043699.full.pdf
- OA Status
- gold
- Cited By
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- References
- 118
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3119439912
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3119439912Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1136/bmjopen-2020-043699Digital Object Identifier
- Title
-
Study protocol: randomised controlled trial evaluating exercise therapy as a supplemental treatment strategy in early multiple sclerosis: the Early Multiple Sclerosis Exercise Study (EMSES)Work title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-01-01Full publication date if available
- Authors
-
Morten Riemenschneider, Lars G. Hvid, Steffen Ringgaard, Mikkel Nygaard, Simon Fristed Eskildsen, Thor Petersen, Egon Stenager, Ulrik DalgasList of authors in order
- Landing page
-
https://doi.org/10.1136/bmjopen-2020-043699Publisher landing page
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https://bmjopen.bmj.com/content/bmjopen/11/1/e043699.full.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://bmjopen.bmj.com/content/bmjopen/11/1/e043699.full.pdfDirect OA link when available
- Concepts
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Medicine, Multiple sclerosis, Physical therapy, Randomized controlled trial, Alternative medicine, Protocol (science), Exercise therapy, Clinical trial, Neurology, Physical medicine and rehabilitation, Internal medicine, Pathology, PsychiatryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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16Total citation count in OpenAlex
- Citations by year (recent)
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2025: 3, 2024: 2, 2023: 4, 2022: 6, 2021: 1Per-year citation counts (last 5 years)
- References (count)
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118Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.secondary | 175 |
| abstract_inverted_index.symptoms, | 185 |
| abstract_inverted_index.treatment | 51, 65, 92 |
| abstract_inverted_index.‘window | 71 |
| abstract_inverted_index.Committees | 211 |
| abstract_inverted_index.MS-related | 184 |
| abstract_inverted_index.Protection | 223 |
| abstract_inverted_index.controlled | 123 |
| abstract_inverted_index.disability | 45, 178 |
| abstract_inverted_index.effective, | 29 |
| abstract_inverted_index.especially | 30 |
| abstract_inverted_index.experience | 41 |
| abstract_inverted_index.follow-up) | 116 |
| abstract_inverted_index.introduced | 32 |
| abstract_inverted_index.overlooked | 70 |
| abstract_inverted_index.randomised | 122 |
| abstract_inverted_index.registered | 218 |
| abstract_inverted_index.scientific | 234, 241 |
| abstract_inverted_index.strategies | 52 |
| abstract_inverted_index.supervised | 132 |
| abstract_inverted_index.therefore, | 48 |
| abstract_inverted_index.treatments | 26 |
| abstract_inverted_index.warranted. | 54 |
| abstract_inverted_index.NCT03322761 | 246 |
| abstract_inverted_index.exploratory | 187 |
| abstract_inverted_index.investigate | 87 |
| abstract_inverted_index.multicentre | 118 |
| abstract_inverted_index.strategies, | 66 |
| abstract_inverted_index.Introduction | 0 |
| abstract_inverted_index.conferences. | 242 |
| abstract_inverted_index.high-intense | 133 |
| abstract_inverted_index.progression, | 46, 179 |
| abstract_inverted_index.registration | 244 |
| abstract_inverted_index.supplemental | 49, 64 |
| abstract_inverted_index.Additionally, | 141 |
| abstract_inverted_index.dissemination | 201 |
| abstract_inverted_index.peer-reviewed | 235 |
| abstract_inverted_index.supplementary | 91 |
| abstract_inverted_index.opportunity’ | 73 |
| abstract_inverted_index.single-blinded | 119 |
| abstract_inverted_index.(1-10-72-388-17) | 216 |
| abstract_inverted_index.(2016-051-000001 | 225 |
| abstract_inverted_index.population-based | 148 |
| abstract_inverted_index.disease-modifying | 25 |
| abstract_inverted_index.neurodegeneration | 13 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5023683369 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 8 |
| corresponding_institution_ids | https://openalex.org/I204337017 |
| citation_normalized_percentile.value | 0.85703505 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |