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Patrick K. Mescher ·

YOU? · · 2023 · Open Access · · DOI: https://doi.org/10.1016/b978-0-323-91259-4.00068-0 · OA: W4385981185

Randomized controlled trials, systemic reviews, and meta-analyses, if performed carefully and thoughtfully, are at the pinnacle of evidence-based medicine. However, these types of studies can suffer from two major complications, subject nonadherence, and missing outcomes. The purpose of this chapter is to provide an overview of intention-to-treat, as-treated, and per-protocol methodology in the setting of randomized control trials and discuss the effects of employing one method over another.