Subnormothermic Perfusion with H2S Donor AP39 Improves DCD Porcine Renal Graft Outcomes in an Ex Vivo Model of Kidney Preservation and Reperfusion Article Swipe
Smriti Juriasingani
,
Aushanth Ruthirakanthan
,
Mahms Richard-Mohamed
,
Masoud Akbari
,
Shahid Aquil
,
Sanjay V. Patel
,
Rafid Al-Ogaili
,
Matthew Whiteman
,
Patrick Luke
,
Alp Şener
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/biom11030446
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/biom11030446
Cold preservation is the standard of care for renal grafts. However, research on alternatives like perfusion at higher temperatures and supplementing preservation solutions with hydrogen sulfide (H2S) has gained momentum. In this study, we investigated whether adding H2S donor AP39 to porcine blood during subnormothermic perfusion at 21 °C improves renal graft outcomes. Porcine kidneys were nephrectomized after 30 min of clamping the renal pedicles and treated to 4 h of static cold storage (SCS) on ice or ex vivo subnormothermic perfusion at 21 °C with autologous blood alone (SNT) or with AP39 (SNTAP). All kidneys were reperfused ex vivo with autologous blood at 37 °C for 4 h. Urine output, histopathology and RNAseq were used to evaluate the renal graft function, injury and gene expression profiles, respectively. The SNTAP group exhibited significantly higher urine output than other groups during preservation and reperfusion, along with significantly lower apoptotic injury compared to the SCS group. The SNTAP group also exhibited differential pro-survival gene expression patterns compared to the SCS (downregulation of pro-apoptotic genes) and SNT (downregulation of hypoxia response genes) groups. Subnormothermic perfusion at 21 °C with H2S-supplemented blood improves renal graft outcomes. Further research is needed to facilitate the clinical translation of this approach.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/biom11030446
- https://www.mdpi.com/2218-273X/11/3/446/pdf?version=1616055535
- OA Status
- gold
- Cited By
- 22
- References
- 51
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3136025736
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- OpenAlex ID
-
https://openalex.org/W3136025736Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/biom11030446Digital Object Identifier
- Title
-
Subnormothermic Perfusion with H2S Donor AP39 Improves DCD Porcine Renal Graft Outcomes in an Ex Vivo Model of Kidney Preservation and ReperfusionWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-03-17Full publication date if available
- Authors
-
Smriti Juriasingani, Aushanth Ruthirakanthan, Mahms Richard-Mohamed, Masoud Akbari, Shahid Aquil, Sanjay V. Patel, Rafid Al-Ogaili, Matthew Whiteman, Patrick Luke, Alp ŞenerList of authors in order
- Landing page
-
https://doi.org/10.3390/biom11030446Publisher landing page
- PDF URL
-
https://www.mdpi.com/2218-273X/11/3/446/pdf?version=1616055535Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/2218-273X/11/3/446/pdf?version=1616055535Direct OA link when available
- Concepts
-
Ex vivo, Perfusion, Machine perfusion, Kidney, Cold storage, Medicine, Urology, In vivo, Downregulation and upregulation, Reperfusion injury, Andrology, Surgery, Transplantation, Ischemia, Internal medicine, Chemistry, Biology, Gene, Biochemistry, Biotechnology, Horticulture, Liver transplantationTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
22Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 3, 2024: 7, 2023: 4, 2022: 5, 2021: 3Per-year citation counts (last 5 years)
- References (count)
-
51Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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