Subsequent female breast cancer risk associated with anthracycline chemotherapy for childhood cancer Article Swipe
YOU?
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· 2023
· Open Access
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· DOI: https://doi.org/10.1038/s41591-023-02514-1
Anthracycline-based chemotherapy is associated with increased subsequent breast cancer (SBC) risk in female childhood cancer survivors, but the current evidence is insufficient to support early breast cancer screening recommendations for survivors treated with anthracyclines. In this study, we pooled individual patient data of 17,903 survivors from six well-established studies, of whom 782 (4.4%) developed a SBC, and analyzed dose-dependent effects of individual anthracycline agents on developing SBC and interactions with chest radiotherapy. A dose-dependent increased SBC risk was seen for doxorubicin (hazard ratio (HR) per 100 mg m − 2 : 1.24, 95% confidence interval (CI): 1.18–1.31), with more than twofold increased risk for survivors treated with ≥200 mg m −2 cumulative doxorubicin dose versus no doxorubicin (HR: 2.50 for 200–299 mg m − 2 , HR: 2.33 for 300–399 mg m − 2 and HR: 2.78 for ≥400 mg m − 2 ). For daunorubicin, the associations were not statistically significant. Epirubicin was associated with increased SBC risk (yes/no, HR: 3.25, 95% CI: 1.59–6.63). For patients treated with or without chest irradiation, HRs per 100 mg m − 2 of doxorubicin were 1.11 (95% CI: 1.02–1.21) and 1.26 (95% CI: 1.17–1.36), respectively. Our findings support that early initiation of SBC surveillance may be reasonable for survivors who received ≥200 mg m − 2 cumulative doxorubicin dose and should be considered in SBC surveillance guidelines for survivors and future treatment protocols.
Related Topics
- Type
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- https://www.nature.com/articles/s41591-023-02514-1.pdf
- OA Status
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- OpenAlex ID
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Raw OpenAlex JSON
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https://openalex.org/W4386609943Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1038/s41591-023-02514-1Digital Object Identifier
- Title
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Subsequent female breast cancer risk associated with anthracycline chemotherapy for childhood cancerWork title
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articleOpenAlex work type
- Language
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enPrimary language
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2023Year of publication
- Publication date
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2023-09-01Full publication date if available
- Authors
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Yuehan Wang, Cécile M. Ronckers, Flora E. van Leeuwen, Chaya S. Moskowitz, Wendy M. Leisenring, Gregory T. Armstrong, Florent de Vathaire, Melissa M. Hudson, Claudia E. Kuehni, Michael Arnold, Charlotte Demoor‐Goldschmidt, Daniel M. Green, Tara O. Henderson, Rebecca M. Howell, Matthew J. Ehrhardt, Joseph P. Neglia, Kevin C. Oeffinger, Helena J. H. van der Pal, Leslie L. Robison, Michael Schaapveld, Lucie M. Turcotte, Nicolas Waespe, Leontien C. M. Kremer, Jop C. Teepen, Flora E. van Leeuwen, Florent de Vathaire, Helena J. H. van der Pal, Nadia Haddy, Ibrahima Diallo, K. Scott Baker, Amy Berrington de González, Miriam Conces, Louis S. Constine, Mike Hawkins, Jacqueline J. Loonen, Marloes Louwerens, Geert O. Janssens, Lene Mellemkjær, Raoul C. Reulen, Jeanette Falck WintherList of authors in order
- Landing page
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https://doi.org/10.1038/s41591-023-02514-1Publisher landing page
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https://www.nature.com/articles/s41591-023-02514-1.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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hybridOpen access status per OpenAlex
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https://www.nature.com/articles/s41591-023-02514-1.pdfDirect OA link when available
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Anthracycline, Breast cancer, Medicine, Childhood cancer, Oncology, Chemotherapy, Internal medicine, CancerTop concepts (fields/topics) attached by OpenAlex
- Cited by
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36Total citation count in OpenAlex
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2025: 12, 2024: 23, 2023: 1Per-year citation counts (last 5 years)
- References (count)
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34Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| institutions_distinct_count | 40 |
| corresponding_institution_ids | https://openalex.org/I4210127118 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8500000238418579 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.99727013 |
| citation_normalized_percentile.is_in_top_1_percent | True |
| citation_normalized_percentile.is_in_top_10_percent | True |