Substrate structure modulates the catalytic dynamics of HDAC8 at the single-molecule level Article Swipe

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Seungyong You , Sakurako Tani , Sanku Mallik , Zhongyu Yang , Mohiuddin Quadir , Yongki Choi ·

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YOU? · · 2025 · Open Access · · DOI: https://doi.org/10.1039/d5cy00729a · OA: W4415402869

Single-molecule analysis reveals how ligand modifications synergistically control HDAC8 catalysis by stabilizing active conformations, providing mechanistic insights into ligand-regulated enzymatic catalysis.

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