Subthreshold delayed afterdepolarizations provide an important arrhythmogenic substrate in the border zone of infarcted hearts Article Swipe

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Medicine Border zone Cardiology Ventricular tachycardia Internal medicine Myocardial infarction Afterdepolarization Infarction Fibrosis Tachycardia Subthreshold conduction Electrophysiology Repolarization Physics Quantum mechanics Voltage Transistor

Fernando O. Campos , Yohannes Shiferaw , John Whitaker , Gernot Plank , Martin J. Bishop ·

YOU? · · 2022 · Open Access · · DOI: https://doi.org/10.1016/j.hrthm.2022.10.026 · OA: W4308261788

Sudden cardiac arrest resulting from myocardial infarction (MI) is most often due to ventricular tachycardia (VT). In the infarcted heart, VT has been shown to originate at the periphery of the scar1. Such tissue is often termed the infarct border zone (BZ) and is comprised of a heterogeneous admixture of fibrosis and surviving cardiomyocytes2. Extended regions of BZ tissue that penetrate through non-conducting necrotic core scar can give rise to anatomical isthmuses which provide slow conducting re-entrant pathways that can help sustain VT circuits3.