Successful Diagnoses and Remarkable Metabolic Disorders in Patients With Solitary Hypothalamic Mass: A Case Series Report Article Swipe
Boni Xiang
,
Quanya Sun
,
Min He
,
Wei Wu
,
Bin Lü
,
Shuo Zhang
,
Zhaoyun Zhang
,
Yehong Yang
,
Yiming Li
,
Yue Wu
,
Zhenwei Yao
,
Haixia Cheng
,
Li Pan
,
Qing Miao
,
Yongfei Wang
,
Hongying Ye
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3389/fendo.2021.693669
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3389/fendo.2021.693669
Background Solitary intracranial hypothalamic mass occurs rarely. The etiological diagnosis of solitary hypothalamus lesion is challenging and often unachievable. Although previous studies indicated that lesions affecting the hypothalamus often cause significant metabolic disorders, few reports about the metabolic disturbances of patients with solitary hypothalamic mass have been reported. Method Twenty-five patients with solitary hypothalamus lesions who had been evaluated and treated in Huashan Hospital from January 2010 to December 2020 were retrospectively enrolled. The clinical manifestations, radiological features, endocrine and metabolic disorders, and pathology were analyzed. Results The male to female ratio was 5/20. The median age of onset was 22 (19, 35) years old. The most common initial symptom was polydipsia/polyuria (19/25, 76.0%) and amenorrhea (9/20, 45.0%). A high prevalence of hypopituitarism of different axes was found, with almost all no less than 80%. Central hypogonadism (21/22, 95.5%) and central diabetes insipidus (19/21, 90.5%) were the top two pituitary dysfunctions. Conclusive diagnoses were achieved by intracranial surgical biopsy/resection or stereotactic biopsy in 16 cases and by examining extracranial lesions in 3 cases. The pathological results were various, and the most common diagnoses were Langerhans cell histiocytosis (7/19) and hypothalamitis (5/19). The mean timespan from onset to diagnosis in the 19 cases was 34 ± 26 months. Metabolic evaluations revealed remarkable metabolic disorders, including hyperlipidemia (13/16, 81.3%), hyperglycemia (10/16, 62.5%), hyperuricemia (12/20, 60%), overweight/obesity (13/20, 65.0%), and hepatic adipose infiltration (10/13, 76.6%). Conclusion Either surgical or stereotactic biopsy will be a reliable and relatively safe procedure to help to confirm the pathological diagnosis of solitary hypothalamic mass. Metabolic disorders were severe in patients with solitary hypothalamic mass. The management of such cases should cover both the treatment of the primary disease, as well as the endocrine and metabolic disorders
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fendo.2021.693669
- https://www.frontiersin.org/articles/10.3389/fendo.2021.693669/pdf
- OA Status
- gold
- Cited By
- 2
- References
- 35
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3199086749
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3199086749Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/fendo.2021.693669Digital Object Identifier
- Title
-
Successful Diagnoses and Remarkable Metabolic Disorders in Patients With Solitary Hypothalamic Mass: A Case Series ReportWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-09-16Full publication date if available
- Authors
-
Boni Xiang, Quanya Sun, Min He, Wei Wu, Bin Lü, Shuo Zhang, Zhaoyun Zhang, Yehong Yang, Yiming Li, Yue Wu, Zhenwei Yao, Haixia Cheng, Li Pan, Qing Miao, Yongfei Wang, Hongying YeList of authors in order
- Landing page
-
https://doi.org/10.3389/fendo.2021.693669Publisher landing page
- PDF URL
-
https://www.frontiersin.org/articles/10.3389/fendo.2021.693669/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.frontiersin.org/articles/10.3389/fendo.2021.693669/pdfDirect OA link when available
- Concepts
-
Medicine, Diabetes insipidus, Hypopituitarism, Polyuria, Hypothalamic disease, Internal medicine, Diabetes mellitus, Pathology, Gastroenterology, Endocrinology, Hypogonadotropic hypogonadism, HormoneTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
2Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2Per-year citation counts (last 5 years)
- References (count)
-
35Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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