[11C]Carbonyl Difluoride—a New and Highly Efficient [11C]Carbonyl Group Transfer Agent Article Swipe
Jimmy E. Jakobsson
,
Shuiyu Lu
,
Sanjay Telu
,
Victor W. Pike
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1002/anie.201915414
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1002/anie.201915414
Herein, the synthesis and use of [ 11 C]carbonyl difluoride for labeling heterocycles with [ 11 C]carbonyl groups in high molar activity is described. A very mild single‐pass gas‐phase conversion of [ 11 C]carbon monoxide into [ 11 C]carbonyl difluoride over silver(II) fluoride provides easy access to this new synthon in robust quantitative yield for labeling a broad range of cyclic substrates, for example, imidazolidin‐2‐ones, thiazolidin‐2‐ones, and oxazolidin‐2‐ones. Labeling reactions may utilize close‐to‐stoichiometric precursor quantities and short reaction times at room temperature in a wide range of solvents while also showing high water tolerability. The overall radiosynthesis protocol is both simple and reproducible. The required apparatus can be constructed from widely available parts and is therefore well suited to be automated for PET radiotracer production. We foresee that this straightforward method will gain wide acceptance for PET radiotracer syntheses across the radiochemistry community.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/anie.201915414
- OA Status
- green
- Cited By
- 18
- References
- 34
- Related Works
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- OpenAlex ID
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All OpenAlex metadata
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https://openalex.org/W3003374709Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/anie.201915414Digital Object Identifier
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[11C]Carbonyl Difluoride—a New and Highly Efficient [11C]Carbonyl Group Transfer AgentWork title
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
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2020-01-29Full publication date if available
- Authors
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Jimmy E. Jakobsson, Shuiyu Lu, Sanjay Telu, Victor W. PikeList of authors in order
- Landing page
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https://doi.org/10.1002/anie.201915414Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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greenOpen access status per OpenAlex
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https://www.ncbi.nlm.nih.gov/pmc/articles/7174138Direct OA link when available
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Synthon, Chemistry, Difluoride, Radiosynthesis, Stoichiometry, Carbon monoxide, Yield (engineering), Combinatorial chemistry, Organic chemistry, Catalysis, Biotechnology, In vivo, Materials science, Biology, MetallurgyTop concepts (fields/topics) attached by OpenAlex
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18Total citation count in OpenAlex
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2025: 1, 2024: 1, 2023: 6, 2022: 3, 2021: 3Per-year citation counts (last 5 years)
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34Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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