Super-Resolution Ultrasound Localization Microscopy of Microvascular Structure and Flow for Distinguishing Metastatic Lymph Nodes – An Initial Human Study Article Swipe
Jiaqi Zhu
,
Chao Zhang
,
Kirsten Christensen-Jeffries
,
Ge Zhang
,
Sevan Harput
,
Christopher Dunsby
,
Pintong Huang
,
Meng‐Xing Tang
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1055/a-1917-0016
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1055/a-1917-0016
Purpose Detecting and distinguishing metastatic lymph nodes (LNs) from those with benign lymphadenopathy are crucial for cancer diagnosis and prognosis but remain a clinical challenge. A recent advance in super-resolution ultrasound (SRUS) through localizing individual microbubbles has broken the diffraction limit and tracking enabled in vivo noninvasive imaging of vascular morphology and flow dynamics at a microscopic level. In this study we hypothesize that SRUS enables quantitative markers to distinguish metastatic LNs from benign ones in patients with lymphadenopathy. Materials and Methods Clinical contrast-enhanced ultrasound image sequences of LNs from 6 patients with lymph node metastasis and 4 with benign lymphadenopathy were acquired and motion-corrected. These were then used to generate super-resolution microvascular images and super-resolved velocity maps. From these SRUS images, morphological and functional measures were obtained including micro-vessel density, fractal dimension, mean flow speed, and Local Flow Direction Irregularity (LFDI) measuring the variance in local flow direction. These measures were compared between pathologically proven reactive and metastasis LNs. Results Our initial results indicate that the difference in the indicator of flow irregularity (LFDI) derived from the SRUS images is statistically significant between the two groups. The LFDI is 60% higher in metastatic LNs compared with reactive nodes. Conclusion This pilot study demonstrates the feasibility of super-resolution ultrasound for clinical imaging of lymph nodes and the potential of using the irregularity of local blood flow directions afforded by SRUS for the characterization of LNs.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1055/a-1917-0016
- http://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-1917-0016.pdf
- OA Status
- bronze
- Cited By
- 45
- References
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- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4303473228
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4303473228Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1055/a-1917-0016Digital Object Identifier
- Title
-
Super-Resolution Ultrasound Localization Microscopy of Microvascular Structure and Flow for Distinguishing Metastatic Lymph Nodes – An Initial Human StudyWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-10-07Full publication date if available
- Authors
-
Jiaqi Zhu, Chao Zhang, Kirsten Christensen-Jeffries, Ge Zhang, Sevan Harput, Christopher Dunsby, Pintong Huang, Meng‐Xing TangList of authors in order
- Landing page
-
https://doi.org/10.1055/a-1917-0016Publisher landing page
- PDF URL
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https://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-1917-0016.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
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bronzeOpen access status per OpenAlex
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https://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-1917-0016.pdfDirect OA link when available
- Concepts
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Lymph, Ultrasound, Lymph node, Medicine, Radiology, Metastasis, Biomedical engineering, Pathology, Cancer, Internal medicineTop concepts (fields/topics) attached by OpenAlex
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45Total citation count in OpenAlex
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2025: 19, 2024: 16, 2023: 8, 2022: 2Per-year citation counts (last 5 years)
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30Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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