Supplemental Figure 6 from KT-253, a Novel MDM2 Degrader and p53 Stabilizer, Has Superior Potency and Efficacy than MDM2 Small-Molecule Inhibitors Article Swipe

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Yogesh K. Chutake , Michele Mayo , Nancy Dumont , Jessica Filiatrault , Susanne B. Breitkopf , Patricia Cho , Dapeng Chen , Vaishali Dixit , William Proctor , Eric Kuhn , Sarah Bollinger Martinez , Alice McDonald , Jianfeng Qi , Kan‐Nian Hu , Rahul Karnik , Joseph D. Growney , Kirti Sharma , Stefanie S. Schalm , Ashwin Gollerkeri , Nello Mainolfi , Juliet Williams , Matthew M. Weiss ·

YOU? · · 2025 · Open Access · · DOI: https://doi.org/10.1158/1535-7163.28713642

Supplemental Figure 6: KT 253 activity in p53 WT ABC subtype DLBCL model but not p53 mutated ABC subtype DLBCL model.

Related Topics

Mdm2

Potency (Pharmacology)

Mechanical Engineering

Concepts

Mdm2 Potency Small molecule Stabilizer (aeronautics) Chemistry Medicine Biochemistry Engineering In vitro Mechanical engineering Gene

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Type: preprint
Language: en
Landing Page: https://doi.org/10.1158/1535-7163.28713642
OA Status: gold
Related Works: 10
OpenAlex ID: https://openalex.org/W4409079805

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DOI: https://doi.org/10.1158/1535-7163.28713642

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Title: Supplemental Figure 6 from KT-253, a Novel MDM2 Degrader and p53 Stabilizer, Has Superior Potency and Efficacy than MDM2 Small-Molecule Inhibitors

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Type: preprint

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Language: en

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Publication year: 2025

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Publication date: 2025-04-02

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Authors: Yogesh K. Chutake, Michele Mayo, Nancy Dumont, Jessica Filiatrault, Susanne B. Breitkopf, Patricia Cho, Dapeng Chen, Vaishali Dixit, William Proctor, Eric Kuhn, Sarah Bollinger Martinez, Alice McDonald, Jianfeng Qi, Kan‐Nian Hu, Rahul Karnik, Joseph D. Growney, Kirti Sharma, Stefanie S. Schalm, Ashwin Gollerkeri, Nello Mainolfi, Juliet Williams, Matthew M. Weiss

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Landing page: https://doi.org/10.1158/1535-7163.28713642

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Concepts: Mdm2, Potency, Small molecule, Stabilizer (aeronautics), Chemistry, Medicine, Biochemistry, Engineering, In vitro, Mechanical engineering, Gene

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