Supplemental Figures S1-5 from Pharmacologically Increasing Mdm2 Inhibits DNA Repair and Cooperates with Genotoxic Agents to Kill p53-Inactivated Ovarian Cancer Cells Article Swipe

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Mdm2 Cancer research Ovarian cancer Mutant DNA damage Cancer Cancer cell Genotoxicity Chemistry DNA Biology Cell culture Medicine Gene Internal medicine Genetics Toxicity

Alexia M. Carrillo , Mellissa Hicks , Dineo Khabele , Christine M. Eischen ·

YOU? · · 2023 · Open Access · · DOI: https://doi.org/10.1158/1541-7786.22514469 · OA: W4362610777

<p>Supplemental Figures S1-5. Figure S1. Nutlin inhibits γH2AX foci formation and prolongs resolution. Figure S2. Inhibition of pS/TQ foci formation and resolution by Nutlin. Figure S3. Nutlin inhibits γH2AX foci formation and resolution in ovarian cancer cells. Figure S4. Nutlin cooperates with genotoxic agents in p53-inactivated ovarian cancer cells. Figure S5. Nutlin and DNA damaging drugs combine to kill ovarian cancer cells that harbor mutant p53.</p>