Supplementary Data from ERK-Mediated Loss of miR-199a-3p and Induction of EGR1 Act as a “Toggle Switch” of GBM Cell Dedifferentiation into NANOG- and OCT4-Positive Cells Article Swipe

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Fabien Almairac , Laurent Turchi , Nathalie Sakakini , David Nicolas Debruyne , Sarah Elkeurti , Elisabet Gjernes , Béatrice Polo , Laurence Bianchini , Denys Fontaine , Philippe Paquis , Hervé Chneiweiss , Marie‐Pierre Junier , Patrick Verrando , Fanny Burel‐Vandenbos , Thierry Virolle ·

YOU? · · 2023 · Open Access · · DOI: https://doi.org/10.1158/0008-5472.22425114

These figures describe that : dedifferentiation restores stem-like and tumorigenic properties (sup fig 5); EGFR and ERK inhibitions on the dedifferentiation process (sup fig 6 and 7).

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Homeobox protein NANOG EGR1 MAPK/ERK pathway Cell biology Cancer research Chemistry Biology Downregulation and upregulation Embryonic stem cell Kinase Genetics Gene Induced pluripotent stem cell

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Type: preprint
Language: en
Landing Page: https://doi.org/10.1158/0008-5472.22425114
OA Status: gold
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OpenAlex ID: https://openalex.org/W4361877461

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DOI: https://doi.org/10.1158/0008-5472.22425114

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Title: Supplementary Data from ERK-Mediated Loss of miR-199a-3p and Induction of EGR1 Act as a “Toggle Switch” of GBM Cell Dedifferentiation into NANOG- and OCT4-Positive Cells

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Language: en

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Publication year: 2023

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Publication date: 2023-03-31

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Authors: Fabien Almairac, Laurent Turchi, Nathalie Sakakini, David Nicolas Debruyne, Sarah Elkeurti, Elisabet Gjernes, Béatrice Polo, Laurence Bianchini, Denys Fontaine, Philippe Paquis, Hervé Chneiweiss, Marie‐Pierre Junier, Patrick Verrando, Fanny Burel‐Vandenbos, Thierry Virolle

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Landing page: https://doi.org/10.1158/0008-5472.22425114

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Concepts: Homeobox protein NANOG, EGR1, MAPK/ERK pathway, Cell biology, Cancer research, Chemistry, Biology, Downregulation and upregulation, Embryonic stem cell, Kinase, Genetics, Gene, Induced pluripotent stem cell

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