Supplementary Fig. S5 from Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity Article Swipe

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Tae‐Min Kim , Seung‐Hyun Jung , Chang Hyeok An , Sung Hak Lee , In-Pyo Baek , Min Sung Kim , Sung‐Won Park , Je‐Keun Rhee , Sug-Hyung Lee , Yeun‐Jun Chung ·

YOU? · · 2023 · Open Access · · DOI: https://doi.org/10.1158/1078-0432.22459461.v1

Supplementary Fig. S5. Validation of redundant APC mutations. A, For one case (CRC2), two redundant APC mutations are validated by Sanger sequencing. One nonsense mutation (C>T; left) and one frameshift indel (AG>A; right) are shown for seven regional biopsies for the given case. For one primary case (CRC2-P1), the nonsense mutation is not observed, consistent with the metastasis-clonal presentation of this mutation. B, The copy number changes of the entire chromosome 5 are shown for seven regional biopsies. Entire loss of chromosome 5 is observed for CRC-P1. APC locus is incidated with a red dotted line.

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Sanger sequencing Frameshift mutation Genetics Indel Nonsense mutation Colorectal cancer Biology Genetic heterogeneity Mutation Cancer research Cancer Missense mutation Gene Genotype Single-nucleotide polymorphism Phenotype

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Language: en
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Title: Supplementary Fig. S5 from Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity

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Publication year: 2023

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Authors: Tae‐Min Kim, Seung‐Hyun Jung, Chang Hyeok An, Sung Hak Lee, In-Pyo Baek, Min Sung Kim, Sung‐Won Park, Je‐Keun Rhee, Sug-Hyung Lee, Yeun‐Jun Chung

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Concepts: Sanger sequencing, Frameshift mutation, Genetics, Indel, Nonsense mutation, Colorectal cancer, Biology, Genetic heterogeneity, Mutation, Cancer research, Cancer, Missense mutation, Gene, Genotype, Single-nucleotide polymorphism, Phenotype

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