Supplementary Figure 1-9 from Bortezomib Induces Anti–Multiple Myeloma Immune Response Mediated by cGAS/STING Pathway Activation Article Swipe

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Annamaria Gullà , Eugenio Morelli , Mehmet Samur , Cirino Botta , Teru Hideshima , Giada Bianchi , Mariateresa Fulciniti , Stefano Malvestiti , Rao Prabhala , Srikanth Talluri , Kenneth Wen , Yu‐Tzu Tai , Paul G. Richardson , Dharminder Chauhan , Tomasz Sewastianik , Ruben D. Carrasco , Nikhil C. Munshi , Kenneth C. Anderson ·

YOU? · · 2023 · Open Access · · DOI: https://doi.org/10.1158/2643-3230.22543534

Supp. Fig. 1 shows that bortezomib induces ICD in vitro. Suppl. Fig.2 shows that bortezomib treatment of co-culture of dendritic and T cells does not induce T cell maturation. Suppl. Fig. 3 shows that bortezomib-induced MM cell death promotes proliferation of CD4+ and CD8+ naïve T cells. Suppl. Fig.4 shows that bortezomib treatment generates a robust immune response against MM cells. Suppl. Fig. 5 shows pathways enriched by bortezomib treatment in vivo. Suppl. Fig. 6 shows Gene Ontology analysis of ICD signature genes. Suppl. Fig. 7 shows that MM cells engage in a type-I IFN response after treatment with bortezomib. Suppl. Fig. 8 shows type-I IFN response after bortezomib in MM is STING dependent. Suppl. Fig. 9 shows STING agonists potentiate bortezomib-induced anti-tumor immunity.

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Bortezomib Sting Immune system Multiple myeloma CD8 In vivo Cancer research In vitro Chemistry Medicine Biology Immunology Biochemistry Aerospace engineering Engineering Biotechnology

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Type: preprint
Language: en
Landing Page: https://doi.org/10.1158/2643-3230.22543534
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Title: Supplementary Figure 1-9 from Bortezomib Induces Anti–Multiple Myeloma Immune Response Mediated by cGAS/STING Pathway Activation

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Publication year: 2023

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Publication date: 2023-04-04

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Authors: Annamaria Gullà, Eugenio Morelli, Mehmet Samur, Cirino Botta, Teru Hideshima, Giada Bianchi, Mariateresa Fulciniti, Stefano Malvestiti, Rao Prabhala, Srikanth Talluri, Kenneth Wen, Yu‐Tzu Tai, Paul G. Richardson, Dharminder Chauhan, Tomasz Sewastianik, Ruben D. Carrasco, Nikhil C. Munshi, Kenneth C. Anderson

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Landing page: https://doi.org/10.1158/2643-3230.22543534

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Concepts: Bortezomib, Sting, Immune system, Multiple myeloma, CD8, In vivo, Cancer research, In vitro, Chemistry, Medicine, Biology, Immunology, Biochemistry, Aerospace engineering, Engineering, Biotechnology

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