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Tiffany A. Katz , Serena G. Liao , Vincent J. Palmieri , Robert K. Dearth , Thushangi N. Pathiraja , Zhiguang Huo , Patricia Shaw , Sarah Small , Nancy E. Davidson , David G. Peters , George C. Tseng , Steffi Oesterreich , Adrian V. Lee ·

YOU? · · 2023 · Open Access · · DOI: https://doi.org/10.1158/1940-6207.22526112.v1

Supplementary Figure S1. Experimental design and quality control analysis for Methyl-Seq data. (A) FVB mice were bred to become pregnant (parous, P) and underwent a complete pregnancy (Pr), lactation (L), and Involution (I). Animals were then euthanized immediately after involution (Early, E), or 6.5 months post-involution (Late, Lt). Nulliparous (NP) age matched controls were included at each time point. Mammary glands were harvested and genomic DNA was isolated and processed for input into the SureSelectXT Mouse Methy-Seq Enrichment Platform for DNA methylation analysis. (B) Quantitative RT-PCR of cell type specific transcripts. Each data point represents an animal, and bars represent mean ? SEM.

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Involution (esoterism) DNA methylation Lactation Biology Methylation genomic DNA Andrology DNA Molecular biology Internal medicine Genetics Pregnancy Endocrinology Gene Gene expression Medicine Neuroscience Consciousness

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Type: preprint
Language: en
Landing Page: https://doi.org/10.1158/1940-6207.22526112.v1
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DOI: https://doi.org/10.1158/1940-6207.22526112.v1

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Title: Supplementary Figure 1 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition

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Language: en

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Publication year: 2023

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Publication date: 2023-04-03

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Authors: Tiffany A. Katz, Serena G. Liao, Vincent J. Palmieri, Robert K. Dearth, Thushangi N. Pathiraja, Zhiguang Huo, Patricia Shaw, Sarah Small, Nancy E. Davidson, David G. Peters, George C. Tseng, Steffi Oesterreich, Adrian V. Lee

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Concepts: Involution (esoterism), DNA methylation, Lactation, Biology, Methylation, genomic DNA, Andrology, DNA, Molecular biology, Internal medicine, Genetics, Pregnancy, Endocrinology, Gene, Gene expression, Medicine, Neuroscience, Consciousness

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