Supplementary Figure 2 from Cyclin E2 Overexpression Is Associated with Endocrine Resistance but not Insensitivity to CDK2 Inhibition in Human Breast Cancer Cells Article Swipe

PDF

C. Elizabeth Caldon , C. Marcelo Sergio , Jian Kang , Anita Muthukaruppan , Marijke N. Boersma , Andrew Stone , Jane Barraclough , Christine S. Lee , Michael A. Black , Lance D. Miller , Julia M.W. Gee , Rob I. Nicholson , Robert L. Sutherland , Cristin G. Print , Elizabeth A. Musgrove ·

YOU? · · 2023 · Open Access · · DOI: https://doi.org/10.1158/1535-7163.22496370

PDF file, 78KB, Supplementary Figure 2: Deregulation of cyclin E in tamoxifen-resistant cells. MCF-7C and TAMR cells were treated with vehicle, OH-Tam (100 nM) or fulvestrant (10 nM). A: S phase percentage derived from flow cytometry of propidium iodide-stained cells. B: Densitometry of Western blots using GAPDH as a loading control. Data represent the mean � range of duplicate experiments.

Related Topics

Concepts

Fulvestrant Propidium iodide Flow cytometry Cyclin E Tamoxifen Cancer research Chemistry Breast cancer Internal medicine Cyclin Molecular biology Endocrinology Cancer Medicine Biology Cell cycle Apoptosis Biochemistry Programmed cell death

Metadata

Type: preprint
Language: en
Landing Page: https://doi.org/10.1158/1535-7163.22496370
PDF: https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_Cyclin_E2_Overexpression_Is_Associated_with_Endocrine_Resistance_but_not_Insensitivity_to_CDK2_Inhibition_in_Human_Breast_Cancer_Cells/22496370/1/files/39954384.pdf
OA Status: gold
Related Works: 10
OpenAlex ID: https://openalex.org/W4362479607

All OpenAlex metadata

Raw OpenAlex JSON

OpenAlex ID: https://openalex.org/W4362479607

Canonical identifier for this work in OpenAlex
DOI: https://doi.org/10.1158/1535-7163.22496370

Digital Object Identifier
Title: Supplementary Figure 2 from Cyclin E2 Overexpression Is Associated with Endocrine Resistance but not Insensitivity to CDK2 Inhibition in Human Breast Cancer Cells

Work title
Type: preprint

OpenAlex work type
Language: en

Primary language
Publication year: 2023

Year of publication
Publication date: 2023-04-03

Full publication date if available
Authors: C. Elizabeth Caldon, C. Marcelo Sergio, Jian Kang, Anita Muthukaruppan, Marijke N. Boersma, Andrew Stone, Jane Barraclough, Christine S. Lee, Michael A. Black, Lance D. Miller, Julia M.W. Gee, Rob I. Nicholson, Robert L. Sutherland, Cristin G. Print, Elizabeth A. Musgrove

List of authors in order
Landing page: https://doi.org/10.1158/1535-7163.22496370

Publisher landing page
PDF URL: https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_Cyclin_E2_Overexpression_Is_Associated_with_Endocrine_Resistance_but_not_Insensitivity_to_CDK2_Inhibition_in_Human_Breast_Cancer_Cells/22496370/1/files/39954384.pdf

Direct link to full text PDF
Open access: Yes

Whether a free full text is available
OA status: gold

Open access status per OpenAlex
OA URL: https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_Cyclin_E2_Overexpression_Is_Associated_with_Endocrine_Resistance_but_not_Insensitivity_to_CDK2_Inhibition_in_Human_Breast_Cancer_Cells/22496370/1/files/39954384.pdf

Direct OA link when available
Concepts: Fulvestrant, Propidium iodide, Flow cytometry, Cyclin E, Tamoxifen, Cancer research, Chemistry, Breast cancer, Internal medicine, Cyclin, Molecular biology, Endocrinology, Cancer, Medicine, Biology, Cell cycle, Apoptosis, Biochemistry, Programmed cell death

Top concepts (fields/topics) attached by OpenAlex
Cited by: 0

Total citation count in OpenAlex
Related works (count): 10

Other works algorithmically related by OpenAlex

Full payload

id	https://openalex.org/W4362479607
doi	https://doi.org/10.1158/1535-7163.22496370
ids.doi	https://doi.org/10.1158/1535-7163.22496370
ids.openalex	https://openalex.org/W4362479607
fwci	0.0
type	preprint
title	Supplementary Figure 2 from Cyclin E2 Overexpression Is Associated with Endocrine Resistance but not Insensitivity to CDK2 Inhibition in Human Breast Cancer Cells
biblio.issue
biblio.volume
biblio.last_page
biblio.first_page
topics[0].id	https://openalex.org/T10885
topics[0].field.id	https://openalex.org/fields/13
topics[0].field.display_name	Biochemistry, Genetics and Molecular Biology
topics[0].score	0.5370000004768372
topics[0].domain.id	https://openalex.org/domains/1
topics[0].domain.display_name	Life Sciences
topics[0].subfield.id	https://openalex.org/subfields/1312
topics[0].subfield.display_name	Molecular Biology
topics[0].display_name	Gene expression and cancer classification
is_xpac	False
apc_list
apc_paid
concepts[0].id	https://openalex.org/C2780482068
concepts[0].level	5
concepts[0].score	0.7587882280349731
concepts[0].wikidata	https://www.wikidata.org/wiki/Q5508491
concepts[0].display_name	Fulvestrant
concepts[1].id	https://openalex.org/C2775934118
concepts[1].level	4
concepts[1].score	0.7448223829269409
concepts[1].wikidata	https://www.wikidata.org/wiki/Q424169
concepts[1].display_name	Propidium iodide
concepts[2].id	https://openalex.org/C553184892
concepts[2].level	2
concepts[2].score	0.5279392600059509
concepts[2].wikidata	https://www.wikidata.org/wiki/Q1141429
concepts[2].display_name	Flow cytometry
concepts[3].id	https://openalex.org/C94561458
concepts[3].level	5
concepts[3].score	0.4991605281829834
concepts[3].wikidata	https://www.wikidata.org/wiki/Q24724860
concepts[3].display_name	Cyclin E
concepts[4].id	https://openalex.org/C2777176818
concepts[4].level	4
concepts[4].score	0.45470932126045227
concepts[4].wikidata	https://www.wikidata.org/wiki/Q412178
concepts[4].display_name	Tamoxifen
concepts[5].id	https://openalex.org/C502942594
concepts[5].level	1
concepts[5].score	0.4063228666782379
concepts[5].wikidata	https://www.wikidata.org/wiki/Q3421914
concepts[5].display_name	Cancer research
concepts[6].id	https://openalex.org/C185592680
concepts[6].level	0
concepts[6].score	0.3894061744213104
concepts[6].wikidata	https://www.wikidata.org/wiki/Q2329
concepts[6].display_name	Chemistry
concepts[7].id	https://openalex.org/C530470458
concepts[7].level	3
concepts[7].score	0.36849159002304077
concepts[7].wikidata	https://www.wikidata.org/wiki/Q128581
concepts[7].display_name	Breast cancer
concepts[8].id	https://openalex.org/C126322002
concepts[8].level	1
concepts[8].score	0.3661314845085144
concepts[8].wikidata	https://www.wikidata.org/wiki/Q11180
concepts[8].display_name	Internal medicine
concepts[9].id	https://openalex.org/C120089663
concepts[9].level	4
concepts[9].score	0.35504889488220215
concepts[9].wikidata	https://www.wikidata.org/wiki/Q59250999
concepts[9].display_name	Cyclin
concepts[10].id	https://openalex.org/C153911025
concepts[10].level	1
concepts[10].score	0.34845006465911865
concepts[10].wikidata	https://www.wikidata.org/wiki/Q7202
concepts[10].display_name	Molecular biology
concepts[11].id	https://openalex.org/C134018914
concepts[11].level	1
concepts[11].score	0.3285980224609375
concepts[11].wikidata	https://www.wikidata.org/wiki/Q162606
concepts[11].display_name	Endocrinology
concepts[12].id	https://openalex.org/C121608353
concepts[12].level	2
concepts[12].score	0.32774752378463745
concepts[12].wikidata	https://www.wikidata.org/wiki/Q12078
concepts[12].display_name	Cancer
concepts[13].id	https://openalex.org/C71924100
concepts[13].level	0
concepts[13].score	0.322867214679718
concepts[13].wikidata	https://www.wikidata.org/wiki/Q11190
concepts[13].display_name	Medicine
concepts[14].id	https://openalex.org/C86803240
concepts[14].level	0
concepts[14].score	0.28647327423095703
concepts[14].wikidata	https://www.wikidata.org/wiki/Q420
concepts[14].display_name	Biology
concepts[15].id	https://openalex.org/C29537977
concepts[15].level	3
concepts[15].score	0.2681276798248291
concepts[15].wikidata	https://www.wikidata.org/wiki/Q188941
concepts[15].display_name	Cell cycle
concepts[16].id	https://openalex.org/C190283241
concepts[16].level	2
concepts[16].score	0.1664009690284729
concepts[16].wikidata	https://www.wikidata.org/wiki/Q14599311
concepts[16].display_name	Apoptosis
concepts[17].id	https://openalex.org/C55493867
concepts[17].level	1
concepts[17].score	0.1099405586719513
concepts[17].wikidata	https://www.wikidata.org/wiki/Q7094
concepts[17].display_name	Biochemistry
concepts[18].id	https://openalex.org/C31573885
concepts[18].level	3
concepts[18].score	0.0
concepts[18].wikidata	https://www.wikidata.org/wiki/Q304484
concepts[18].display_name	Programmed cell death
keywords[0].id	https://openalex.org/keywords/fulvestrant
keywords[0].score	0.7587882280349731
keywords[0].display_name	Fulvestrant
keywords[1].id	https://openalex.org/keywords/propidium-iodide
keywords[1].score	0.7448223829269409
keywords[1].display_name	Propidium iodide
keywords[2].id	https://openalex.org/keywords/flow-cytometry
keywords[2].score	0.5279392600059509
keywords[2].display_name	Flow cytometry
keywords[3].id	https://openalex.org/keywords/cyclin-e
keywords[3].score	0.4991605281829834
keywords[3].display_name	Cyclin E
keywords[4].id	https://openalex.org/keywords/tamoxifen
keywords[4].score	0.45470932126045227
keywords[4].display_name	Tamoxifen
keywords[5].id	https://openalex.org/keywords/cancer-research
keywords[5].score	0.4063228666782379
keywords[5].display_name	Cancer research
keywords[6].id	https://openalex.org/keywords/chemistry
keywords[6].score	0.3894061744213104
keywords[6].display_name	Chemistry
keywords[7].id	https://openalex.org/keywords/breast-cancer
keywords[7].score	0.36849159002304077
keywords[7].display_name	Breast cancer
keywords[8].id	https://openalex.org/keywords/internal-medicine
keywords[8].score	0.3661314845085144
keywords[8].display_name	Internal medicine
keywords[9].id	https://openalex.org/keywords/cyclin
keywords[9].score	0.35504889488220215
keywords[9].display_name	Cyclin
keywords[10].id	https://openalex.org/keywords/molecular-biology
keywords[10].score	0.34845006465911865
keywords[10].display_name	Molecular biology
keywords[11].id	https://openalex.org/keywords/endocrinology
keywords[11].score	0.3285980224609375
keywords[11].display_name	Endocrinology
keywords[12].id	https://openalex.org/keywords/cancer
keywords[12].score	0.32774752378463745
keywords[12].display_name	Cancer
keywords[13].id	https://openalex.org/keywords/medicine
keywords[13].score	0.322867214679718
keywords[13].display_name	Medicine
keywords[14].id	https://openalex.org/keywords/biology
keywords[14].score	0.28647327423095703
keywords[14].display_name	Biology
keywords[15].id	https://openalex.org/keywords/cell-cycle
keywords[15].score	0.2681276798248291
keywords[15].display_name	Cell cycle
keywords[16].id	https://openalex.org/keywords/apoptosis
keywords[16].score	0.1664009690284729
keywords[16].display_name	Apoptosis
keywords[17].id	https://openalex.org/keywords/biochemistry
keywords[17].score	0.1099405586719513
keywords[17].display_name	Biochemistry
language	en
locations[0].id	doi:10.1158/1535-7163.22496370
locations[0].is_oa	True
locations[0].source
locations[0].license	cc-by
locations[0].pdf_url	https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_Cyclin_E2_Overexpression_Is_Associated_with_Endocrine_Resistance_but_not_Insensitivity_to_CDK2_Inhibition_in_Human_Breast_Cancer_Cells/22496370/1/files/39954384.pdf
locations[0].version	acceptedVersion
locations[0].raw_type	posted-content
locations[0].license_id	https://openalex.org/licenses/cc-by
locations[0].is_accepted	True
locations[0].is_published	False
locations[0].raw_source_name
locations[0].landing_page_url	https://doi.org/10.1158/1535-7163.22496370
indexed_in	crossref
authorships[0].author.id	https://openalex.org/A5018714307
authorships[0].author.orcid
authorships[0].author.display_name	C. Elizabeth Caldon
authorships[0].author_position	first
authorships[0].raw_author_name	C. Elizabeth Caldon
authorships[0].is_corresponding	False
authorships[1].author.id	https://openalex.org/A5049710826
authorships[1].author.orcid	https://orcid.org/0000-0002-5426-0583
authorships[1].author.display_name	C. Marcelo Sergio
authorships[1].author_position	middle
authorships[1].raw_author_name	C. Marcelo Sergio
authorships[1].is_corresponding	False
authorships[2].author.id	https://openalex.org/A5100447381
authorships[2].author.orcid	https://orcid.org/0000-0001-8995-5636
authorships[2].author.display_name	Jian Kang
authorships[2].author_position	middle
authorships[2].raw_author_name	Jian Kang
authorships[2].is_corresponding	False
authorships[3].author.id	https://openalex.org/A5020330950
authorships[3].author.orcid
authorships[3].author.display_name	Anita Muthukaruppan
authorships[3].author_position	middle
authorships[3].raw_author_name	Anita Muthukaruppan
authorships[3].is_corresponding	False
authorships[4].author.id	https://openalex.org/A5057160141
authorships[4].author.orcid
authorships[4].author.display_name	Marijke N. Boersma
authorships[4].author_position	middle
authorships[4].raw_author_name	Marijke N. Boersma
authorships[4].is_corresponding	False
authorships[5].author.id	https://openalex.org/A5103937255
authorships[5].author.orcid
authorships[5].author.display_name	Andrew Stone
authorships[5].author_position	middle
authorships[5].raw_author_name	Andrew Stone
authorships[5].is_corresponding	False
authorships[6].author.id	https://openalex.org/A5074300293
authorships[6].author.orcid
authorships[6].author.display_name	Jane Barraclough
authorships[6].author_position	middle
authorships[6].raw_author_name	Jane Barraclough
authorships[6].is_corresponding	False
authorships[7].author.id	https://openalex.org/A5048203748
authorships[7].author.orcid
authorships[7].author.display_name	Christine S. Lee
authorships[7].author_position	middle
authorships[7].raw_author_name	Christine S. Lee
authorships[7].is_corresponding	False
authorships[8].author.id	https://openalex.org/A5063087649
authorships[8].author.orcid	https://orcid.org/0000-0003-1174-6054
authorships[8].author.display_name	Michael A. Black
authorships[8].author_position	middle
authorships[8].raw_author_name	Michael A. Black
authorships[8].is_corresponding	False
authorships[9].author.id	https://openalex.org/A5024804165
authorships[9].author.orcid	https://orcid.org/0000-0003-3799-2528
authorships[9].author.display_name	Lance D. Miller
authorships[9].author_position	middle
authorships[9].raw_author_name	Lance D. Miller
authorships[9].is_corresponding	False
authorships[10].author.id	https://openalex.org/A5012364827
authorships[10].author.orcid	https://orcid.org/0000-0001-6483-2015
authorships[10].author.display_name	Julia M.W. Gee
authorships[10].author_position	middle
authorships[10].raw_author_name	Julia M. Gee
authorships[10].is_corresponding	False
authorships[11].author.id	https://openalex.org/A5112863661
authorships[11].author.orcid
authorships[11].author.display_name	Rob I. Nicholson
authorships[11].author_position	middle
authorships[11].raw_author_name	Rob I. Nicholson
authorships[11].is_corresponding	False
authorships[12].author.id	https://openalex.org/A5110319158
authorships[12].author.orcid
authorships[12].author.display_name	Robert L. Sutherland
authorships[12].author_position	middle
authorships[12].raw_author_name	Robert L. Sutherland
authorships[12].is_corresponding	False
authorships[13].author.id	https://openalex.org/A5064023142
authorships[13].author.orcid	https://orcid.org/0000-0001-8345-7812
authorships[13].author.display_name	Cristin G. Print
authorships[13].author_position	middle
authorships[13].raw_author_name	Cristin G. Print
authorships[13].is_corresponding	False
authorships[14].author.id	https://openalex.org/A5067798845
authorships[14].author.orcid
authorships[14].author.display_name	Elizabeth A. Musgrove
authorships[14].author_position	last
authorships[14].raw_author_name	Elizabeth A. Musgrove
authorships[14].is_corresponding	False
has_content.pdf	True
has_content.grobid_xml	True
is_paratext	False
open_access.is_oa	True
open_access.oa_url	https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_Cyclin_E2_Overexpression_Is_Associated_with_Endocrine_Resistance_but_not_Insensitivity_to_CDK2_Inhibition_in_Human_Breast_Cancer_Cells/22496370/1/files/39954384.pdf
open_access.oa_status	gold
open_access.any_repository_has_fulltext	False
created_date	2025-10-10T00:00:00
display_name	Supplementary Figure 2 from Cyclin E2 Overexpression Is Associated with Endocrine Resistance but not Insensitivity to CDK2 Inhibition in Human Breast Cancer Cells
has_fulltext	False
is_retracted	False
updated_date	2025-11-06T03:46:38.306776
primary_topic.id	https://openalex.org/T10885
primary_topic.field.id	https://openalex.org/fields/13
primary_topic.field.display_name	Biochemistry, Genetics and Molecular Biology
primary_topic.score	0.5370000004768372
primary_topic.domain.id	https://openalex.org/domains/1
primary_topic.domain.display_name	Life Sciences
primary_topic.subfield.id	https://openalex.org/subfields/1312
primary_topic.subfield.display_name	Molecular Biology
primary_topic.display_name	Gene expression and cancer classification
related_works	https://openalex.org/W2166171580, https://openalex.org/W1966383348, https://openalex.org/W2366177270, https://openalex.org/W3088795248, https://openalex.org/W1988393949, https://openalex.org/W2074501545, https://openalex.org/W2327045279, https://openalex.org/W2124716540, https://openalex.org/W2096993973, https://openalex.org/W1998738134
cited_by_count	0
locations_count	1
best_oa_location.id	doi:10.1158/1535-7163.22496370
best_oa_location.is_oa	True
best_oa_location.source
best_oa_location.license	cc-by
best_oa_location.pdf_url	https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_Cyclin_E2_Overexpression_Is_Associated_with_Endocrine_Resistance_but_not_Insensitivity_to_CDK2_Inhibition_in_Human_Breast_Cancer_Cells/22496370/1/files/39954384.pdf
best_oa_location.version	acceptedVersion
best_oa_location.raw_type	posted-content
best_oa_location.license_id	https://openalex.org/licenses/cc-by
best_oa_location.is_accepted	True
best_oa_location.is_published	False
best_oa_location.raw_source_name
best_oa_location.landing_page_url	https://doi.org/10.1158/1535-7163.22496370
primary_location.id	doi:10.1158/1535-7163.22496370
primary_location.is_oa	True
primary_location.source
primary_location.license	cc-by
primary_location.pdf_url	https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_Cyclin_E2_Overexpression_Is_Associated_with_Endocrine_Resistance_but_not_Insensitivity_to_CDK2_Inhibition_in_Human_Breast_Cancer_Cells/22496370/1/files/39954384.pdf
primary_location.version	acceptedVersion
primary_location.raw_type	posted-content
primary_location.license_id	https://openalex.org/licenses/cc-by
primary_location.is_accepted	True
primary_location.is_published	False
primary_location.raw_source_name
primary_location.landing_page_url	https://doi.org/10.1158/1535-7163.22496370
publication_date	2023-04-03
publication_year	2023
referenced_works_count	0
abstract_inverted_index.E	9
abstract_inverted_index.S	29
abstract_inverted_index.a	48
abstract_inverted_index.2:	5
abstract_inverted_index.A:	28
abstract_inverted_index.B:	40
abstract_inverted_index.as	47
abstract_inverted_index.in	10
abstract_inverted_index.of	7, 36, 42, 57
abstract_inverted_index.or	24
abstract_inverted_index.(10	26
abstract_inverted_index.and	14
abstract_inverted_index.nM)	23
abstract_inverted_index.the	53
abstract_inverted_index.�	55
abstract_inverted_index.(100	22
abstract_inverted_index.Data	51
abstract_inverted_index.TAMR	15
abstract_inverted_index.flow	34
abstract_inverted_index.from	33
abstract_inverted_index.mean	54
abstract_inverted_index.nM).	27
abstract_inverted_index.were	17
abstract_inverted_index.with	19
abstract_inverted_index.78KB,	2
abstract_inverted_index.GAPDH	46
abstract_inverted_index.blots	44
abstract_inverted_index.cells	16
abstract_inverted_index.file,	1
abstract_inverted_index.phase	30
abstract_inverted_index.range	56
abstract_inverted_index.using	45
abstract_inverted_index.Figure	4
abstract_inverted_index.MCF-7C	13
abstract_inverted_index.OH-Tam	21
abstract_inverted_index.cells.	12, 39
abstract_inverted_index.cyclin	8
abstract_inverted_index.Western	43
abstract_inverted_index.derived	32
abstract_inverted_index.loading	49
abstract_inverted_index.treated	18
abstract_inverted_index.control.	50
abstract_inverted_index.vehicle,	20
abstract_inverted_index.cytometry	35
abstract_inverted_index.duplicate	58
abstract_inverted_index.propidium	37
abstract_inverted_index.represent	52
abstract_inverted_index.percentage	31
abstract_inverted_index.fulvestrant	25
abstract_inverted_index.<p>PDF	0
abstract_inverted_index.Densitometry	41
abstract_inverted_index.Deregulation	6
abstract_inverted_index.Supplementary	3
abstract_inverted_index.iodide-stained	38
abstract_inverted_index.tamoxifen-resistant	11
abstract_inverted_index.experiments.</p>	59
cited_by_percentile_year
countries_distinct_count	0
institutions_distinct_count	15
sustainable_development_goals[0].id	https://metadata.un.org/sdg/3
sustainable_development_goals[0].score	0.8399999737739563
sustainable_development_goals[0].display_name	Good health and well-being
citation_normalized_percentile.value	0.16239581
citation_normalized_percentile.is_in_top_1_percent	False
citation_normalized_percentile.is_in_top_10_percent	False