Supplementary Figure 2 from PF-04691502, a Potent and Selective Oral Inhibitor of PI3K and mTOR Kinases with Antitumor Activity Article Swipe

PDF

Jing Yuan , Pramod P. Mehta , Min-Jean Yin , Shaoxian Sun , Aihua Zou , Jeffrey Chen , Kristina Rafidi , Feng Zheng , Jeffrey C. Nickel , Jon Engebretsen , Jill Hallin , Alessandra Blasina , Eric Zhang , Leslie Nguyen , Minghao Sun , Peter K. Vogt , Aileen McHarg , Hengmiao Cheng , James G. Christensen , Julie L.C. Kan , Shubha Bagrodia ·

YOU? · · 2023 · Open Access · · DOI: https://doi.org/10.1158/1535-7163.22496632.v1

PDF file - 271K

Related Topics

Concepts

Kinase Discovery and development of mTOR inhibitors PI3K/AKT/mTOR pathway Chemistry Pharmacology Cancer research Medicine Biochemistry Signal transduction

Metadata

Type: preprint
Language: en
Landing Page: https://doi.org/10.1158/1535-7163.22496632.v1
PDF: https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_PF-04691502_a_Potent_and_Selective_Oral_Inhibitor_of_PI3K_and_mTOR_Kinases_with_Antitumor_Activity/22496632/1/files/39954658.pdf
OA Status: gold
Related Works: 10
OpenAlex ID: https://openalex.org/W4362620017

All OpenAlex metadata

Raw OpenAlex JSON

OpenAlex ID: https://openalex.org/W4362620017

Canonical identifier for this work in OpenAlex
DOI: https://doi.org/10.1158/1535-7163.22496632.v1

Digital Object Identifier
Title: Supplementary Figure 2 from PF-04691502, a Potent and Selective Oral Inhibitor of PI3K and mTOR Kinases with Antitumor Activity

Work title
Type: preprint

OpenAlex work type
Language: en

Primary language
Publication year: 2023

Year of publication
Publication date: 2023-04-03

Full publication date if available
Authors: Jing Yuan, Pramod P. Mehta, Min-Jean Yin, Shaoxian Sun, Aihua Zou, Jeffrey Chen, Kristina Rafidi, Feng Zheng, Jeffrey C. Nickel, Jon Engebretsen, Jill Hallin, Alessandra Blasina, Eric Zhang, Leslie Nguyen, Minghao Sun, Peter K. Vogt, Aileen McHarg, Hengmiao Cheng, James G. Christensen, Julie L.C. Kan, Shubha Bagrodia

List of authors in order
Landing page: https://doi.org/10.1158/1535-7163.22496632.v1

Publisher landing page
PDF URL: https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_PF-04691502_a_Potent_and_Selective_Oral_Inhibitor_of_PI3K_and_mTOR_Kinases_with_Antitumor_Activity/22496632/1/files/39954658.pdf

Direct link to full text PDF
Open access: Yes

Whether a free full text is available
OA status: gold

Open access status per OpenAlex
OA URL: https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_PF-04691502_a_Potent_and_Selective_Oral_Inhibitor_of_PI3K_and_mTOR_Kinases_with_Antitumor_Activity/22496632/1/files/39954658.pdf

Direct OA link when available
Concepts: Kinase, Discovery and development of mTOR inhibitors, PI3K/AKT/mTOR pathway, Chemistry, Pharmacology, Cancer research, Medicine, Biochemistry, Signal transduction

Top concepts (fields/topics) attached by OpenAlex
Cited by: 0

Total citation count in OpenAlex
Related works (count): 10

Other works algorithmically related by OpenAlex

Full payload

id	https://openalex.org/W4362620017
doi	https://doi.org/10.1158/1535-7163.22496632.v1
ids.doi	https://doi.org/10.1158/1535-7163.22496632.v1
ids.openalex	https://openalex.org/W4362620017
fwci	0.0
type	preprint
title	Supplementary Figure 2 from PF-04691502, a Potent and Selective Oral Inhibitor of PI3K and mTOR Kinases with Antitumor Activity
biblio.issue
biblio.volume
biblio.last_page
biblio.first_page
topics[0].id	https://openalex.org/T10952
topics[0].field.id	https://openalex.org/fields/13
topics[0].field.display_name	Biochemistry, Genetics and Molecular Biology
topics[0].score	0.7926999926567078
topics[0].domain.id	https://openalex.org/domains/1
topics[0].domain.display_name	Life Sciences
topics[0].subfield.id	https://openalex.org/subfields/1312
topics[0].subfield.display_name	Molecular Biology
topics[0].display_name	PI3K/AKT/mTOR signaling in cancer
is_xpac	False
apc_list
apc_paid
concepts[0].id	https://openalex.org/C184235292
concepts[0].level	2
concepts[0].score	0.7159504294395447
concepts[0].wikidata	https://www.wikidata.org/wiki/Q421851
concepts[0].display_name	Kinase
concepts[1].id	https://openalex.org/C183713625
concepts[1].level	4
concepts[1].score	0.7126555442810059
concepts[1].wikidata	https://www.wikidata.org/wiki/Q5282002
concepts[1].display_name	Discovery and development of mTOR inhibitors
concepts[2].id	https://openalex.org/C86554907
concepts[2].level	3
concepts[2].score	0.6705779433250427
concepts[2].wikidata	https://www.wikidata.org/wiki/Q285613
concepts[2].display_name	PI3K/AKT/mTOR pathway
concepts[3].id	https://openalex.org/C185592680
concepts[3].level	0
concepts[3].score	0.44391822814941406
concepts[3].wikidata	https://www.wikidata.org/wiki/Q2329
concepts[3].display_name	Chemistry
concepts[4].id	https://openalex.org/C98274493
concepts[4].level	1
concepts[4].score	0.41692879796028137
concepts[4].wikidata	https://www.wikidata.org/wiki/Q128406
concepts[4].display_name	Pharmacology
concepts[5].id	https://openalex.org/C502942594
concepts[5].level	1
concepts[5].score	0.33804598450660706
concepts[5].wikidata	https://www.wikidata.org/wiki/Q3421914
concepts[5].display_name	Cancer research
concepts[6].id	https://openalex.org/C71924100
concepts[6].level	0
concepts[6].score	0.27683523297309875
concepts[6].wikidata	https://www.wikidata.org/wiki/Q11190
concepts[6].display_name	Medicine
concepts[7].id	https://openalex.org/C55493867
concepts[7].level	1
concepts[7].score	0.18398046493530273
concepts[7].wikidata	https://www.wikidata.org/wiki/Q7094
concepts[7].display_name	Biochemistry
concepts[8].id	https://openalex.org/C62478195
concepts[8].level	2
concepts[8].score	0.09340611100196838
concepts[8].wikidata	https://www.wikidata.org/wiki/Q828130
concepts[8].display_name	Signal transduction
keywords[0].id	https://openalex.org/keywords/kinase
keywords[0].score	0.7159504294395447
keywords[0].display_name	Kinase
keywords[1].id	https://openalex.org/keywords/discovery-and-development-of-mtor-inhibitors
keywords[1].score	0.7126555442810059
keywords[1].display_name	Discovery and development of mTOR inhibitors
keywords[2].id	https://openalex.org/keywords/pi3k/akt/mtor-pathway
keywords[2].score	0.6705779433250427
keywords[2].display_name	PI3K/AKT/mTOR pathway
keywords[3].id	https://openalex.org/keywords/chemistry
keywords[3].score	0.44391822814941406
keywords[3].display_name	Chemistry
keywords[4].id	https://openalex.org/keywords/pharmacology
keywords[4].score	0.41692879796028137
keywords[4].display_name	Pharmacology
keywords[5].id	https://openalex.org/keywords/cancer-research
keywords[5].score	0.33804598450660706
keywords[5].display_name	Cancer research
keywords[6].id	https://openalex.org/keywords/medicine
keywords[6].score	0.27683523297309875
keywords[6].display_name	Medicine
keywords[7].id	https://openalex.org/keywords/biochemistry
keywords[7].score	0.18398046493530273
keywords[7].display_name	Biochemistry
keywords[8].id	https://openalex.org/keywords/signal-transduction
keywords[8].score	0.09340611100196838
keywords[8].display_name	Signal transduction
language	en
locations[0].id	doi:10.1158/1535-7163.22496632.v1
locations[0].is_oa	True
locations[0].source
locations[0].license	cc-by
locations[0].pdf_url	https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_PF-04691502_a_Potent_and_Selective_Oral_Inhibitor_of_PI3K_and_mTOR_Kinases_with_Antitumor_Activity/22496632/1/files/39954658.pdf
locations[0].version	acceptedVersion
locations[0].raw_type	posted-content
locations[0].license_id	https://openalex.org/licenses/cc-by
locations[0].is_accepted	True
locations[0].is_published	False
locations[0].raw_source_name
locations[0].landing_page_url	https://doi.org/10.1158/1535-7163.22496632.v1
locations[1].id	pmh:oai:figshare.com:article/22496632
locations[1].is_oa	True
locations[1].source.id	https://openalex.org/S4306400572
locations[1].source.issn
locations[1].source.type	repository
locations[1].source.is_oa	False
locations[1].source.issn_l
locations[1].source.is_core	False
locations[1].source.is_in_doaj	False
locations[1].source.display_name	OPAL (Open@LaTrobe) (La Trobe University)
locations[1].source.host_organization	https://openalex.org/I196829312
locations[1].source.host_organization_name	La Trobe University
locations[1].source.host_organization_lineage	https://openalex.org/I196829312
locations[1].license	cc-by
locations[1].pdf_url
locations[1].version	submittedVersion
locations[1].raw_type	Text
locations[1].license_id	https://openalex.org/licenses/cc-by
locations[1].is_accepted	False
locations[1].is_published	False
locations[1].raw_source_name
locations[1].landing_page_url	https://figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_PF-04691502_a_Potent_and_Selective_Oral_Inhibitor_of_PI3K_and_mTOR_Kinases_with_Antitumor_Activity/22496632
indexed_in	crossref
authorships[0].author.id	https://openalex.org/A5082434173
authorships[0].author.orcid	https://orcid.org/0000-0001-9050-4496
authorships[0].author.display_name	Jing Yuan
authorships[0].author_position	first
authorships[0].raw_author_name	Jing Yuan
authorships[0].is_corresponding	False
authorships[1].author.id	https://openalex.org/A5051851544
authorships[1].author.orcid
authorships[1].author.display_name	Pramod P. Mehta
authorships[1].author_position	middle
authorships[1].raw_author_name	Pramod P. Mehta
authorships[1].is_corresponding	False
authorships[2].author.id	https://openalex.org/A5103416325
authorships[2].author.orcid
authorships[2].author.display_name	Min-Jean Yin
authorships[2].author_position	middle
authorships[2].raw_author_name	Min-Jean Yin
authorships[2].is_corresponding	False
authorships[3].author.id	https://openalex.org/A5062122586
authorships[3].author.orcid	https://orcid.org/0000-0003-4751-3025
authorships[3].author.display_name	Shaoxian Sun
authorships[3].author_position	middle
authorships[3].raw_author_name	Shaoxian Sun
authorships[3].is_corresponding	False
authorships[4].author.id	https://openalex.org/A5103075880
authorships[4].author.orcid	https://orcid.org/0000-0002-7672-828X
authorships[4].author.display_name	Aihua Zou
authorships[4].author_position	middle
authorships[4].raw_author_name	Aihua Zou
authorships[4].is_corresponding	False
authorships[5].author.id	https://openalex.org/A5072570750
authorships[5].author.orcid	https://orcid.org/0000-0001-7430-1517
authorships[5].author.display_name	Jeffrey Chen
authorships[5].author_position	middle
authorships[5].raw_author_name	Jeffrey Chen
authorships[5].is_corresponding	False
authorships[6].author.id	https://openalex.org/A5056475776
authorships[6].author.orcid
authorships[6].author.display_name	Kristina Rafidi
authorships[6].author_position	middle
authorships[6].raw_author_name	Kristina Rafidi
authorships[6].is_corresponding	False
authorships[7].author.id	https://openalex.org/A5101733681
authorships[7].author.orcid	https://orcid.org/0000-0002-0721-5288
authorships[7].author.display_name	Feng Zheng
authorships[7].author_position	middle
authorships[7].raw_author_name	Zheng Feng
authorships[7].is_corresponding	False
authorships[8].author.id	https://openalex.org/A5025292117
authorships[8].author.orcid	https://orcid.org/0000-0001-5239-082X
authorships[8].author.display_name	Jeffrey C. Nickel
authorships[8].author_position	middle
authorships[8].raw_author_name	Jeffrey Nickel
authorships[8].is_corresponding	False
authorships[9].author.id	https://openalex.org/A5067457924
authorships[9].author.orcid
authorships[9].author.display_name	Jon Engebretsen
authorships[9].author_position	middle
authorships[9].raw_author_name	Jon Engebretsen
authorships[9].is_corresponding	False
authorships[10].author.id	https://openalex.org/A5009869639
authorships[10].author.orcid	https://orcid.org/0000-0002-8443-7116
authorships[10].author.display_name	Jill Hallin
authorships[10].author_position	middle
authorships[10].raw_author_name	Jill Hallin
authorships[10].is_corresponding	False
authorships[11].author.id	https://openalex.org/A5011956067
authorships[11].author.orcid
authorships[11].author.display_name	Alessandra Blasina
authorships[11].author_position	middle
authorships[11].raw_author_name	Alessandra Blasina
authorships[11].is_corresponding	False
authorships[12].author.id	https://openalex.org/A5104111156
authorships[12].author.orcid
authorships[12].author.display_name	Eric Zhang
authorships[12].author_position	middle
authorships[12].raw_author_name	Eric Zhang
authorships[12].is_corresponding	False
authorships[13].author.id	https://openalex.org/A5081339930
authorships[13].author.orcid
authorships[13].author.display_name	Leslie Nguyen
authorships[13].author_position	middle
authorships[13].raw_author_name	Leslie Nguyen
authorships[13].is_corresponding	False
authorships[14].author.id	https://openalex.org/A5083970082
authorships[14].author.orcid	https://orcid.org/0000-0001-5658-7806
authorships[14].author.display_name	Minghao Sun
authorships[14].author_position	middle
authorships[14].raw_author_name	Minghao Sun
authorships[14].is_corresponding	False
authorships[15].author.id	https://openalex.org/A5010679975
authorships[15].author.orcid	https://orcid.org/0000-0002-4519-7500
authorships[15].author.display_name	Peter K. Vogt
authorships[15].author_position	middle
authorships[15].raw_author_name	Peter K. Vogt
authorships[15].is_corresponding	False
authorships[16].author.id	https://openalex.org/A5027127057
authorships[16].author.orcid
authorships[16].author.display_name	Aileen McHarg
authorships[16].author_position	middle
authorships[16].raw_author_name	Aileen McHarg
authorships[16].is_corresponding	False
authorships[17].author.id	https://openalex.org/A5043590615
authorships[17].author.orcid
authorships[17].author.display_name	Hengmiao Cheng
authorships[17].author_position	middle
authorships[17].raw_author_name	Hengmiao Cheng
authorships[17].is_corresponding	False
authorships[18].author.id	https://openalex.org/A5074923974
authorships[18].author.orcid	https://orcid.org/0000-0003-1835-0335
authorships[18].author.display_name	James G. Christensen
authorships[18].author_position	middle
authorships[18].raw_author_name	James G. Christensen
authorships[18].is_corresponding	False
authorships[19].author.id	https://openalex.org/A5110212693
authorships[19].author.orcid
authorships[19].author.display_name	Julie L.C. Kan
authorships[19].author_position	middle
authorships[19].raw_author_name	Julie L.C. Kan
authorships[19].is_corresponding	False
authorships[20].author.id	https://openalex.org/A5026356938
authorships[20].author.orcid
authorships[20].author.display_name	Shubha Bagrodia
authorships[20].author_position	last
authorships[20].raw_author_name	Shubha Bagrodia
authorships[20].is_corresponding	False
has_content.pdf	True
has_content.grobid_xml	True
is_paratext	False
open_access.is_oa	True
open_access.oa_url	https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_PF-04691502_a_Potent_and_Selective_Oral_Inhibitor_of_PI3K_and_mTOR_Kinases_with_Antitumor_Activity/22496632/1/files/39954658.pdf
open_access.oa_status	gold
open_access.any_repository_has_fulltext	False
created_date	2025-10-10T00:00:00
display_name	Supplementary Figure 2 from PF-04691502, a Potent and Selective Oral Inhibitor of PI3K and mTOR Kinases with Antitumor Activity
has_fulltext	False
is_retracted	False
updated_date	2025-11-06T03:46:38.306776
primary_topic.id	https://openalex.org/T10952
primary_topic.field.id	https://openalex.org/fields/13
primary_topic.field.display_name	Biochemistry, Genetics and Molecular Biology
primary_topic.score	0.7926999926567078
primary_topic.domain.id	https://openalex.org/domains/1
primary_topic.domain.display_name	Life Sciences
primary_topic.subfield.id	https://openalex.org/subfields/1312
primary_topic.subfield.display_name	Molecular Biology
primary_topic.display_name	PI3K/AKT/mTOR signaling in cancer
related_works	https://openalex.org/W2118262694, https://openalex.org/W2080100938, https://openalex.org/W4361893109, https://openalex.org/W4323669281, https://openalex.org/W4361869770, https://openalex.org/W4361869773, https://openalex.org/W2008825756, https://openalex.org/W2968827568, https://openalex.org/W4361869624, https://openalex.org/W3012102643
cited_by_count	0
locations_count	2
best_oa_location.id	doi:10.1158/1535-7163.22496632.v1
best_oa_location.is_oa	True
best_oa_location.source
best_oa_location.license	cc-by
best_oa_location.pdf_url	https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_PF-04691502_a_Potent_and_Selective_Oral_Inhibitor_of_PI3K_and_mTOR_Kinases_with_Antitumor_Activity/22496632/1/files/39954658.pdf
best_oa_location.version	acceptedVersion
best_oa_location.raw_type	posted-content
best_oa_location.license_id	https://openalex.org/licenses/cc-by
best_oa_location.is_accepted	True
best_oa_location.is_published	False
best_oa_location.raw_source_name
best_oa_location.landing_page_url	https://doi.org/10.1158/1535-7163.22496632.v1
primary_location.id	doi:10.1158/1535-7163.22496632.v1
primary_location.is_oa	True
primary_location.source
primary_location.license	cc-by
primary_location.pdf_url	https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_PF-04691502_a_Potent_and_Selective_Oral_Inhibitor_of_PI3K_and_mTOR_Kinases_with_Antitumor_Activity/22496632/1/files/39954658.pdf
primary_location.version	acceptedVersion
primary_location.raw_type	posted-content
primary_location.license_id	https://openalex.org/licenses/cc-by
primary_location.is_accepted	True
primary_location.is_published	False
primary_location.raw_source_name
primary_location.landing_page_url	https://doi.org/10.1158/1535-7163.22496632.v1
publication_date	2023-04-03
publication_year	2023
referenced_works_count	0
abstract_inverted_index.-	2
abstract_inverted_index.file	1
abstract_inverted_index.<p>PDF	0
abstract_inverted_index.271K</p>	3
cited_by_percentile_year
countries_distinct_count	0
institutions_distinct_count	21
citation_normalized_percentile.value	0.2099113
citation_normalized_percentile.is_in_top_1_percent	False
citation_normalized_percentile.is_in_top_10_percent	False