T Cells Improves Survival in Human Colorectal Cancer Article Swipe

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Valeria Governa , Emanuele Trella , Valentina Mele , Luigi Tornillo , Francesca Amicarella , Eleonora Cremonesi , Manuele Giuseppe Muraro , Hui Xu , Raoul A. Droeser , Silvio Däster , Martin Bolli , Raffaele Rosso , Daniel Oertli , Serenella Eppenberger‐Castori , Luigi Terracciano , Giandomenica Iezzi , Giulio C. Spagnoli ·

YOU? · · 2023 · Open Access · · DOI: https://doi.org/10.1158/1078-0432.22467263

CD8+/PBN cross-talk is contact dependent. (A) Cumulative flow-cytometry histograms documenting CD69 expression in CD8+ T cells activated by using different concentrations of surface bound anti-CD3 (TR66, 0.5 and 2Î¼g/ml) and soluble anti CD28 (1Î¼g/ml) upon overnight co-culture in the presence or absence of neutrophils. (B) Representative dot plots showing CD69 expression in peripheral blood CD8+ cells stimulated by suboptimal concentrations of anti-CD3/ anti-CD28 in presence or absence of autologous PBN and in control and transwell conditions, preventing cell-cell contact. (C) Representative plots documenting the effects of anti CD11a mAb on CD69 expression in CD8+ T cells activated by a suboptimal concentration of anti-CD3/anti-CD28 in the presence of autologous PBNs. (D) CFSE dilution was used to assess CD8+ T cell proliferation in cultured stimulated with suboptimal concentrations of anti CD3 mAbs and anti CD28 in the presence or absence of PBN.

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CD28 Flow cytometry CD8 Molecular biology T cell CD3 Chemistry Cytotoxic T cell Biology Immunology Immune system In vitro Biochemistry

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Type: preprint
Language: en
Landing Page: https://doi.org/10.1158/1078-0432.22467263
OA Status: gold
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OpenAlex ID: https://openalex.org/W4362403471

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DOI: https://doi.org/10.1158/1078-0432.22467263

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Title: Supplementary Figure 3 from The Interplay Between Neutrophils and CD8<sup>+</sup> T Cells Improves Survival in Human Colorectal Cancer

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Language: en

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Publication year: 2023

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Publication date: 2023-03-31

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Authors: Valeria Governa, Emanuele Trella, Valentina Mele, Luigi Tornillo, Francesca Amicarella, Eleonora Cremonesi, Manuele Giuseppe Muraro, Hui Xu, Raoul A. Droeser, Silvio Däster, Martin Bolli, Raffaele Rosso, Daniel Oertli, Serenella Eppenberger‐Castori, Luigi Terracciano, Giandomenica Iezzi, Giulio C. Spagnoli

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Landing page: https://doi.org/10.1158/1078-0432.22467263

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Concepts: CD28, Flow cytometry, CD8, Molecular biology, T cell, CD3, Chemistry, Cytotoxic T cell, Biology, Immunology, Immune system, In vitro, Biochemistry

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