Supplementary Figure 3. Western blot analysis of myeloma PC derived from three relapsed/refractory patients treated with selinexor and carfilzomib, alone and in combination. from Synergistic Myeloma Cell Death via Novel Intracellular Activation of Caspase-10–Dependent Apoptosis by Carfilzomib and Selinexor Article Swipe

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Shaun Rosebeck , Mattina M. Alonge , Malathi Kandarpa , Anoop Mayampurath , Samuel L. Volchenboum , Jagoda Jasielec , Dominik Dytfeld , Sean P. Maxwell , Stephanie J. Kraftson , Dilara McCauley , Sharon Shacham , Michael Kauffman , Andrzej Jakubowiak ·

YOU? · · 2023 · Open Access · · DOI: https://doi.org/10.1158/1535-7163.22503988

Plasma cells from patients that have failed on treatment regimens that have included proteasome inhibitors, immunomodulatory drugs, and DNA damaging agents were purified from fresh bone marrow aspirates and treated with selinexor and carfilzomib.

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Carfilzomib Western blot Multiple myeloma Intracellular Bone marrow Medicine Proteasome inhibitor Cancer research Refractory (planetary science) Proteasome Pharmacology Oncology Internal medicine Chemistry Biology Biochemistry Astrobiology Gene

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Type: preprint
Language: en
Landing Page: https://doi.org/10.1158/1535-7163.22503988
OA Status: gold
Related Works: 10
OpenAlex ID: https://openalex.org/W4362494976

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DOI: https://doi.org/10.1158/1535-7163.22503988

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Title: Supplementary Figure 3. Western blot analysis of myeloma PC derived from three relapsed/refractory patients treated with selinexor and carfilzomib, alone and in combination. from Synergistic Myeloma Cell Death via Novel Intracellular Activation of Caspase-10–Dependent Apoptosis by Carfilzomib and Selinexor

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Type: preprint

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Language: en

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Publication year: 2023

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Publication date: 2023-04-03

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Authors: Shaun Rosebeck, Mattina M. Alonge, Malathi Kandarpa, Anoop Mayampurath, Samuel L. Volchenboum, Jagoda Jasielec, Dominik Dytfeld, Sean P. Maxwell, Stephanie J. Kraftson, Dilara McCauley, Sharon Shacham, Michael Kauffman, Andrzej Jakubowiak

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Concepts: Carfilzomib, Western blot, Multiple myeloma, Intracellular, Bone marrow, Medicine, Proteasome inhibitor, Cancer research, Refractory (planetary science), Proteasome, Pharmacology, Oncology, Internal medicine, Chemistry, Biology, Biochemistry, Astrobiology, Gene

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