Supplementary Figure 8 from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers Article Swipe

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Dylan T. Jones , Alessandro Valli , Syed Haider , Zuo‐Feng Zhang , Elizabeth A. Smethurst , Zachary T. Schug , Barrie Peck , Eric O. Aboagye , Susan E. Critchlow , Almut Schulze , Eyal Gottlieb , Michael J.O. Wakelam , Adrian L. Harris ·

YOU? · · 2023 · Open Access · · DOI: https://doi.org/10.1158/1535-7163.22508356.v1

Analysis of saturated, mono-unsaturated and poly-unsaturated phospholipids in MDA-MB-468 and PC3 spheroids. Levels of PC, PE, PI, PS, and SM in MDA-MB-468 and PC3 spheroids treated with inhibitors against metabolic enzymes PDHK, ACC, FASN and DGAT, and signalling enzymes PI3K, Akt and mTOR at two different concentrations. Data were converted to log2 scale for each replicate. Abundance of saturated, monounsaturated and polyunsaturated members within each family were then compared using one-way ANOVA, followed by Tukey Post-hoc test for pair-wise comparison (* p<0.05).

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Enzyme Chemistry PI3K/AKT/mTOR pathway Post hoc Kinase Analysis of variance Lipid metabolism Pathway analysis Biochemistry Internal medicine Gene Signal transduction Medicine Gene expression

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Language: en
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Title: Supplementary Figure 8 from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers

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Language: en

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Publication year: 2023

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Publication date: 2023-04-03

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Authors: Dylan T. Jones, Alessandro Valli, Syed Haider, Zuo‐Feng Zhang, Elizabeth A. Smethurst, Zachary T. Schug, Barrie Peck, Eric O. Aboagye, Susan E. Critchlow, Almut Schulze, Eyal Gottlieb, Michael J.O. Wakelam, Adrian L. Harris

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Concepts: Enzyme, Chemistry, PI3K/AKT/mTOR pathway, Post hoc, Kinase, Analysis of variance, Lipid metabolism, Pathway analysis, Biochemistry, Internal medicine, Gene, Signal transduction, Medicine, Gene expression

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