Supplementary Figure S1 from TR-107, an Agonist of Caseinolytic Peptidase Proteolytic Subunit, Disrupts Mitochondrial Metabolism and Inhibits the Growth of Human Colorectal Cancer Cells Article Swipe

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Michael Giarrizzo , Joseph F. LaComb , Hetvi R. Patel , Rohan G. Reddy , John D. Haley , Lee M. Graves , Edwin J. Iwanowicz , Agnieszka B. Bialkowska ·

YOU? · · 2024 · Open Access · · DOI: https://doi.org/10.1158/1535-7163.27950904

Supplementary Figure S1. Assessment of IC50 of TR-107 in NIH 3T3 cells. (A) NIH 3T3 cells were treated with vehicle control (0.1% DMSO) or various log-fold concentrations of TR-107 as described in Materials and Methods. CellTiter-Glo cell viability assay was performed 72 hours post-treatment. IC50 values (nmol/L) were calculated with GraphPad Prism and listed on each respective graph. Data are presented as mean ± SD (N=6).

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IC50 Viability assay Molecular biology Metabolism Chemistry Cell Biology Biochemistry In vitro

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Language: en
Landing Page: https://doi.org/10.1158/1535-7163.27950904
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Title: Supplementary Figure S1 from TR-107, an Agonist of Caseinolytic Peptidase Proteolytic Subunit, Disrupts Mitochondrial Metabolism and Inhibits the Growth of Human Colorectal Cancer Cells

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Authors: Michael Giarrizzo, Joseph F. LaComb, Hetvi R. Patel, Rohan G. Reddy, John D. Haley, Lee M. Graves, Edwin J. Iwanowicz, Agnieszka B. Bialkowska

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Concepts: IC50, Viability assay, Molecular biology, Metabolism, Chemistry, Cell, Biology, Biochemistry, In vitro

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