Supplementary Figure S14 from TR-107, an Agonist of Caseinolytic Peptidase Proteolytic Subunit, Disrupts Mitochondrial Metabolism and Inhibits the Growth of Human Colorectal Cancer Cells Article Swipe

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Michael Giarrizzo , Joseph F. LaComb , Hetvi R. Patel , Rohan G. Reddy , John D. Haley , Lee M. Graves , Edwin J. Iwanowicz , Agnieszka B. Bialkowska ·

YOU? · · 2024 · Open Access · · DOI: https://doi.org/10.1158/1535-7163.27950889

Supplementary Figure S14. TR-107 treatment impacts the transcriptomic profile of DLD-1 cells. (A) and (B) RT-PCR analysis of components of ISR and ferroptosis pathways in DLD-1 after 24 and 72 hours of TR-107 treatment, respectively. The green lane denotes a 2-fold cut-off, and the red lane – is a 0.5-fold cut-off. Data are presented as mean ± SD values (N=3). *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001.

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Chemistry Metabolism Internal medicine Endocrinology Molecular biology Biology Biochemistry Medicine

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Title: Supplementary Figure S14 from TR-107, an Agonist of Caseinolytic Peptidase Proteolytic Subunit, Disrupts Mitochondrial Metabolism and Inhibits the Growth of Human Colorectal Cancer Cells

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Authors: Michael Giarrizzo, Joseph F. LaComb, Hetvi R. Patel, Rohan G. Reddy, John D. Haley, Lee M. Graves, Edwin J. Iwanowicz, Agnieszka B. Bialkowska

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Concepts: Chemistry, Metabolism, Internal medicine, Endocrinology, Molecular biology, Biology, Biochemistry, Medicine

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