Supplementary Figure S2 from Efficacy and Imaging-Enabled Pharmacodynamic Profiling of KRAS G12C Inhibitors in Xenograft and Genetically Engineered Mouse Models of Cancer Article Swipe

View

Catherine Lee , Ziyue Karen Jiang , Simon Planken , Lisa K. Manzuk , Roberto Ortiz , Michael Hall , Kavon Noorbehesht , Sripad Ram , Timothy Affolter , Gabriel E. Troche , Nathan T. Ihle , Theodore Johnson , Youngwook Ahn , Manfred Kraus , Anand Giddabasappa ·

YOU? · · 2025 · Open Access · · DOI: https://doi.org/10.1158/1535-7163.30733968

Compound A modulates glucose metabolism and pERK signaling in MiaPaCa2 tumors after 3 days of treatment in the PET imaging cohort of animals

Related Topics

Concepts

KRAS Medicine Cancer Cancer research Genetically engineered Pharmacodynamics Pharmacology Profiling (computer programming) Cancer drugs Pharmacokinetics Cancer cell Bioinformatics Metabolism Drug Mutation Synthetic lethality

Metadata

Type: article
Landing Page: https://doi.org/10.1158/1535-7163.30733968
OA Status: gold
OpenAlex ID: https://openalex.org/W7106787114

All OpenAlex metadata

Raw OpenAlex JSON

OpenAlex ID: https://openalex.org/W7106787114

Canonical identifier for this work in OpenAlex
DOI: https://doi.org/10.1158/1535-7163.30733968

Digital Object Identifier
Title: Supplementary Figure S2 from Efficacy and Imaging-Enabled Pharmacodynamic Profiling of KRAS G12C Inhibitors in Xenograft and Genetically Engineered Mouse Models of Cancer

Work title
Type: article

OpenAlex work type
Publication year: 2025

Year of publication
Publication date: 2025-11-27

Full publication date if available
Authors: Catherine Lee, Ziyue Karen Jiang, Simon Planken, Lisa K. Manzuk, Roberto Ortiz, Michael Hall, Kavon Noorbehesht, Sripad Ram, Timothy Affolter, Gabriel E. Troche, Nathan T. Ihle, Theodore Johnson, Youngwook Ahn, Manfred Kraus, Anand Giddabasappa

List of authors in order
Landing page: https://doi.org/10.1158/1535-7163.30733968

Publisher landing page
Open access: Yes

Whether a free full text is available
OA status: gold

Open access status per OpenAlex
OA URL: https://doi.org/10.1158/1535-7163.30733968

Direct OA link when available
Concepts: KRAS, Medicine, Cancer, Cancer research, Genetically engineered, Pharmacodynamics, Pharmacology, Profiling (computer programming), Cancer drugs, Pharmacokinetics, Cancer cell, Bioinformatics, Metabolism, Drug, Mutation, Synthetic lethality

Top concepts (fields/topics) attached by OpenAlex
Cited by: 0

Total citation count in OpenAlex

Full payload

id	https://openalex.org/W7106787114
doi	https://doi.org/10.1158/1535-7163.30733968
ids.doi	https://doi.org/10.1158/1535-7163.30733968
ids.openalex	https://openalex.org/W7106787114
fwci	0.0
type	article
title	Supplementary Figure S2 from Efficacy and Imaging-Enabled Pharmacodynamic Profiling of KRAS G12C Inhibitors in Xenograft and Genetically Engineered Mouse Models of Cancer
biblio.issue
biblio.volume
biblio.last_page
biblio.first_page
is_xpac	False
apc_list
apc_paid
concepts[0].id	https://openalex.org/C2781187634
concepts[0].level	4
concepts[0].score	0.6885621547698975
concepts[0].wikidata	https://www.wikidata.org/wiki/Q20969980
concepts[0].display_name	KRAS
concepts[1].id	https://openalex.org/C71924100
concepts[1].level	0
concepts[1].score	0.6566455960273743
concepts[1].wikidata	https://www.wikidata.org/wiki/Q11190
concepts[1].display_name	Medicine
concepts[2].id	https://openalex.org/C121608353
concepts[2].level	2
concepts[2].score	0.6023414731025696
concepts[2].wikidata	https://www.wikidata.org/wiki/Q12078
concepts[2].display_name	Cancer
concepts[3].id	https://openalex.org/C502942594
concepts[3].level	1
concepts[3].score	0.5926122665405273
concepts[3].wikidata	https://www.wikidata.org/wiki/Q3421914
concepts[3].display_name	Cancer research
concepts[4].id	https://openalex.org/C3019111730
concepts[4].level	3
concepts[4].score	0.5723017454147339
concepts[4].wikidata	https://www.wikidata.org/wiki/Q159236
concepts[4].display_name	Genetically engineered
concepts[5].id	https://openalex.org/C111113717
concepts[5].level	3
concepts[5].score	0.4608411490917206
concepts[5].wikidata	https://www.wikidata.org/wiki/Q725307
concepts[5].display_name	Pharmacodynamics
concepts[6].id	https://openalex.org/C98274493
concepts[6].level	1
concepts[6].score	0.3679147958755493
concepts[6].wikidata	https://www.wikidata.org/wiki/Q128406
concepts[6].display_name	Pharmacology
concepts[7].id	https://openalex.org/C187191949
concepts[7].level	2
concepts[7].score	0.34699150919914246
concepts[7].wikidata	https://www.wikidata.org/wiki/Q1138496
concepts[7].display_name	Profiling (computer programming)
concepts[8].id	https://openalex.org/C3020340455
concepts[8].level	3
concepts[8].score	0.32903051376342773
concepts[8].wikidata	https://www.wikidata.org/wiki/Q974135
concepts[8].display_name	Cancer drugs
concepts[9].id	https://openalex.org/C112705442
concepts[9].level	2
concepts[9].score	0.32067152857780457
concepts[9].wikidata	https://www.wikidata.org/wiki/Q323936
concepts[9].display_name	Pharmacokinetics
concepts[10].id	https://openalex.org/C96232424
concepts[10].level	3
concepts[10].score	0.2999395728111267
concepts[10].wikidata	https://www.wikidata.org/wiki/Q4118072
concepts[10].display_name	Cancer cell
concepts[11].id	https://openalex.org/C60644358
concepts[11].level	1
concepts[11].score	0.2968522906303406
concepts[11].wikidata	https://www.wikidata.org/wiki/Q128570
concepts[11].display_name	Bioinformatics
concepts[12].id	https://openalex.org/C62231903
concepts[12].level	2
concepts[12].score	0.26056578755378723
concepts[12].wikidata	https://www.wikidata.org/wiki/Q1057
concepts[12].display_name	Metabolism
concepts[13].id	https://openalex.org/C2780035454
concepts[13].level	2
concepts[13].score	0.2601521909236908
concepts[13].wikidata	https://www.wikidata.org/wiki/Q8386
concepts[13].display_name	Drug
concepts[14].id	https://openalex.org/C501734568
concepts[14].level	3
concepts[14].score	0.2534503936767578
concepts[14].wikidata	https://www.wikidata.org/wiki/Q42918
concepts[14].display_name	Mutation
concepts[15].id	https://openalex.org/C2778502085
concepts[15].level	4
concepts[15].score	0.2530752420425415
concepts[15].wikidata	https://www.wikidata.org/wiki/Q7662767
concepts[15].display_name	Synthetic lethality
keywords[0].id	https://openalex.org/keywords/kras
keywords[0].score	0.6885621547698975
keywords[0].display_name	KRAS
keywords[1].id	https://openalex.org/keywords/cancer
keywords[1].score	0.6023414731025696
keywords[1].display_name	Cancer
keywords[2].id	https://openalex.org/keywords/genetically-engineered
keywords[2].score	0.5723017454147339
keywords[2].display_name	Genetically engineered
keywords[3].id	https://openalex.org/keywords/pharmacodynamics
keywords[3].score	0.4608411490917206
keywords[3].display_name	Pharmacodynamics
keywords[4].id	https://openalex.org/keywords/profiling
keywords[4].score	0.34699150919914246
keywords[4].display_name	Profiling (computer programming)
keywords[5].id	https://openalex.org/keywords/cancer-drugs
keywords[5].score	0.32903051376342773
keywords[5].display_name	Cancer drugs
language
locations[0].id	doi:10.1158/1535-7163.30733968
locations[0].is_oa	True
locations[0].source
locations[0].license	cc-by
locations[0].pdf_url
locations[0].version	acceptedVersion
locations[0].raw_type	posted-content
locations[0].license_id	https://openalex.org/licenses/cc-by
locations[0].is_accepted	True
locations[0].is_published	False
locations[0].raw_source_name
locations[0].landing_page_url	https://doi.org/10.1158/1535-7163.30733968
indexed_in	crossref
authorships[0].author.id	https://openalex.org/A2096595723
authorships[0].author.orcid	https://orcid.org/0000-0001-5999-2452
authorships[0].author.display_name	Catherine Lee
authorships[0].author_position	first
authorships[0].raw_author_name	Catherine Lee
authorships[0].is_corresponding	True
authorships[1].author.id	https://openalex.org/A2188542289
authorships[1].author.orcid	https://orcid.org/0009-0007-4158-4689
authorships[1].author.display_name	Ziyue Karen Jiang
authorships[1].author_position	middle
authorships[1].raw_author_name	Ziyue Karen Jiang
authorships[1].is_corresponding	False
authorships[2].author.id	https://openalex.org/A2713411454
authorships[2].author.orcid	https://orcid.org/0000-0001-8901-8992
authorships[2].author.display_name	Simon Planken
authorships[2].author_position	middle
authorships[2].raw_author_name	Simon Planken
authorships[2].is_corresponding	False
authorships[3].author.id	https://openalex.org/A4316246736
authorships[3].author.orcid	https://orcid.org/0009-0002-0127-0339
authorships[3].author.display_name	Lisa K. Manzuk
authorships[3].author_position	middle
authorships[3].raw_author_name	Lisa K. Manzuk
authorships[3].is_corresponding	False
authorships[4].author.id	https://openalex.org/A2131614771
authorships[4].author.orcid	https://orcid.org/0000-0002-6578-1966
authorships[4].author.display_name	Roberto Ortiz
authorships[4].author_position	middle
authorships[4].raw_author_name	Roberto Ortiz
authorships[4].is_corresponding	False
authorships[5].author.id	https://openalex.org/A1959815153
authorships[5].author.orcid	https://orcid.org/0000-0001-5652-5971
authorships[5].author.display_name	Michael Hall
authorships[5].author_position	middle
authorships[5].raw_author_name	Michael Hall
authorships[5].is_corresponding	False
authorships[6].author.id	https://openalex.org/A2416835883
authorships[6].author.orcid
authorships[6].author.display_name	Kavon Noorbehesht
authorships[6].author_position	middle
authorships[6].raw_author_name	Kavon Noorbehesht
authorships[6].is_corresponding	False
authorships[7].author.id	https://openalex.org/A2132741038
authorships[7].author.orcid	https://orcid.org/0000-0002-9770-106X
authorships[7].author.display_name	Sripad Ram
authorships[7].author_position	middle
authorships[7].raw_author_name	Sripad Ram
authorships[7].is_corresponding	False
authorships[8].author.id	https://openalex.org/A1952862655
authorships[8].author.orcid
authorships[8].author.display_name	Timothy Affolter
authorships[8].author_position	middle
authorships[8].raw_author_name	Timothy Affolter
authorships[8].is_corresponding	False
authorships[9].author.id	https://openalex.org/A4377305970
authorships[9].author.orcid	https://orcid.org/0000-0003-4466-0732
authorships[9].author.display_name	Gabriel E. Troche
authorships[9].author_position	middle
authorships[9].raw_author_name	Gabriel E. Troche
authorships[9].is_corresponding	False
authorships[10].author.id	https://openalex.org/A2561376595
authorships[10].author.orcid	https://orcid.org/0009-0006-2991-2742
authorships[10].author.display_name	Nathan T. Ihle
authorships[10].author_position	middle
authorships[10].raw_author_name	Nathan T. Ihle
authorships[10].is_corresponding	False
authorships[11].author.id	https://openalex.org/A2168523976
authorships[11].author.orcid	https://orcid.org/0000-0002-8387-6192
authorships[11].author.display_name	Theodore Johnson
authorships[11].author_position	middle
authorships[11].raw_author_name	Theodore Johnson
authorships[11].is_corresponding	False
authorships[12].author.id	https://openalex.org/A2131182459
authorships[12].author.orcid	https://orcid.org/0000-0001-5988-7388
authorships[12].author.display_name	Youngwook Ahn
authorships[12].author_position	middle
authorships[12].raw_author_name	Youngwook Ahn
authorships[12].is_corresponding	False
authorships[13].author.id	https://openalex.org/A1784651053
authorships[13].author.orcid	https://orcid.org/0000-0001-6668-6699
authorships[13].author.display_name	Manfred Kraus
authorships[13].author_position	middle
authorships[13].raw_author_name	Manfred Kraus
authorships[13].is_corresponding	False
authorships[14].author.id	https://openalex.org/A2310667381
authorships[14].author.orcid	https://orcid.org/0000-0002-1546-2481
authorships[14].author.display_name	Anand Giddabasappa
authorships[14].author_position	last
authorships[14].raw_author_name	Anand Giddabasappa
authorships[14].is_corresponding	False
has_content.pdf	False
has_content.grobid_xml	False
is_paratext	False
open_access.is_oa	True
open_access.oa_url	https://doi.org/10.1158/1535-7163.30733968
open_access.oa_status	gold
open_access.any_repository_has_fulltext	False
created_date	2025-11-28T00:00:00
display_name	Supplementary Figure S2 from Efficacy and Imaging-Enabled Pharmacodynamic Profiling of KRAS G12C Inhibitors in Xenograft and Genetically Engineered Mouse Models of Cancer
has_fulltext	False
is_retracted	False
updated_date	2025-11-28T02:12:24.556248
primary_topic
cited_by_count	0
locations_count	1
best_oa_location.id	doi:10.1158/1535-7163.30733968
best_oa_location.is_oa	True
best_oa_location.source
best_oa_location.license	cc-by
best_oa_location.pdf_url
best_oa_location.version	acceptedVersion
best_oa_location.raw_type	posted-content
best_oa_location.license_id	https://openalex.org/licenses/cc-by
best_oa_location.is_accepted	True
best_oa_location.is_published	False
best_oa_location.raw_source_name
best_oa_location.landing_page_url	https://doi.org/10.1158/1535-7163.30733968
primary_location.id	doi:10.1158/1535-7163.30733968
primary_location.is_oa	True
primary_location.source
primary_location.license	cc-by
primary_location.pdf_url
primary_location.version	acceptedVersion
primary_location.raw_type	posted-content
primary_location.license_id	https://openalex.org/licenses/cc-by
primary_location.is_accepted	True
primary_location.is_published	False
primary_location.raw_source_name
primary_location.landing_page_url	https://doi.org/10.1158/1535-7163.30733968
publication_date	2025-11-27
publication_year	2025
referenced_works_count	0
abstract_inverted_index.3	12
abstract_inverted_index.A	1
abstract_inverted_index.in	8, 16
abstract_inverted_index.of	14, 21
abstract_inverted_index.PET	18
abstract_inverted_index.and	5
abstract_inverted_index.the	17
abstract_inverted_index.days	13
abstract_inverted_index.pERK	6
abstract_inverted_index.after	11
abstract_inverted_index.cohort	20
abstract_inverted_index.tumors	10
abstract_inverted_index.glucose	3
abstract_inverted_index.imaging	19
abstract_inverted_index.MiaPaCa2	9
abstract_inverted_index.modulates	2
abstract_inverted_index.signaling	7
abstract_inverted_index.treatment	15
abstract_inverted_index.metabolism	4
abstract_inverted_index.<p>Compound	0
abstract_inverted_index.animals</p>	22
cited_by_percentile_year
countries_distinct_count	0
institutions_distinct_count	15
citation_normalized_percentile