Supplementary Figure S2 from Multiomic Mapping of Acquired Chromosome 1 Copy-Number and Structural Variants to Identify Therapeutic Vulnerabilities in Multiple Myeloma Article Swipe
Eileen M. Boyle
,
Patrick Blaney
,
James H. Stoeckle
,
Yubao Wang
,
Hussein Ghamlouch
,
Dylan Gagler
,
Marc Braunstein
,
Ariel Siegel
,
Xiaoyi Chen
,
Gaurav Varma
,
Monica Jinsi
,
David Kaminetzky
,
Arnaldo Arbini
,
Lydia Montes
,
Jill Corre
,
Even H. Rustad
,
Ola Landgren
,
Francesco Maura
,
Brian A. Walker
,
Michael Bauer
,
Benedetto Bruno
,
Aristotelis Tsirigos
,
Faith E. Davies
,
Gareth J. Morgan
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1158/1078-0432.30709528
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1158/1078-0432.30709528
Chromatin state of different gain region. The regions of gain tend to fall within active chromatin regions with G3, G4, G5, G6, and G8 lying exclusively within A-compartments (100%) across B-cell differentiation states and MM cell lines (U266, RPMI8226, and KMS11). The G1 region also followed this pattern with the exception of KMS11 (where A-compartment represented only 78% of the region). The G2 region showed variability between the normal and malignant phenotype, with moderate switching from to B-compartments of 24%, 21%, and 37% in U266, RPMI8226, and KMS11 respectively. The compartment profile of the G7 region is interesting as each sample contained considerable B-compartment percentage (range 16-82%) but within the conserved A-compartment across all samples lies the well characterised oncogene ABL2. The G9 region showed the greatest variability across all samples and was shifted more towards inactive chromatin (range 45-97%). NBC=Naïve B-cell, MBC=Memory B-cell, GCBC=Germinal Center B-cell, PC=plasma cell.
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https://openalex.org/W4416629533Canonical identifier for this work in OpenAlex
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https://doi.org/10.1158/1078-0432.30709528Digital Object Identifier
- Title
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Supplementary Figure S2 from Multiomic Mapping of Acquired Chromosome 1 Copy-Number and Structural Variants to Identify Therapeutic Vulnerabilities in Multiple MyelomaWork title
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articleOpenAlex work type
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2025Year of publication
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2025-11-25Full publication date if available
- Authors
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Eileen M. Boyle, Patrick Blaney, James H. Stoeckle, Yubao Wang, Hussein Ghamlouch, Dylan Gagler, Marc Braunstein, Ariel Siegel, Xiaoyi Chen, Gaurav Varma, Monica Jinsi, David Kaminetzky, Arnaldo Arbini, Lydia Montes, Jill Corre, Even H. Rustad, Ola Landgren, Francesco Maura, Brian A. Walker, Michael Bauer, Benedetto Bruno, Aristotelis Tsirigos, Faith E. Davies, Gareth J. MorganList of authors in order
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https://doi.org/10.1158/1078-0432.30709528Publisher landing page
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https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_S2_from_Multiomic_Mapping_of_Acquired_Chromosome_1_Copy-Number_and_Structural_Variants_to_Identify_Therapeutic_Vulnerabilities_in_Multiple_Myeloma/30709528/1/files/59834347.pdfDirect link to full text PDF
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goldOpen access status per OpenAlex
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https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_S2_from_Multiomic_Mapping_of_Acquired_Chromosome_1_Copy-Number_and_Structural_Variants_to_Identify_Therapeutic_Vulnerabilities_in_Multiple_Myeloma/30709528/1/files/59834347.pdfDirect OA link when available
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