Supplementary Figure S4 from Multiomic Mapping of Acquired Chromosome 1 Copy-Number and Structural Variants to Identify Therapeutic Vulnerabilities in Multiple Myeloma Article Swipe

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Eileen M. Boyle , Yubao Wang , Dylan Gagler , Louis Williams , Avital Tenenbaum , Ariel Siegel , Gaurav Varma , Jason Avigan , Monica Jinsi , David Kaminetzky , Arnaldo Arbini , Jill Corre , Benedetto Bruno , Faith E. Davies , Gareth J. Morgan ·

YOU? · · 2025 · Open Access · · DOI: https://doi.org/10.1158/1078-0432.30709522

Chromatin state of varying deleted regions. There is a greater variability in terms of chromatin composition of the lost regions in comparision to the region of gain. The D1 region had identical an A-compartment percentage (56%) across all samples and reflected loss of significant subtelomeric region, including TNFRSF4. The D2 region was consistent across all samples (range 96-100% A-compartment) with the exception of KMS11 (47%), however this switch to a B-compartment occurred in a gene-sparse region. The D3 region encompasses the tumour suppressor genes CDKN2C and FAF1 and had similar active chromatin profiles (range 44-77%) except in RPMI8226 (0%). The D4 and D5 regions lie completely (100%) and near completely (>87%) in inactive compartments. Interestingly, the small A-compartments in D5 across U266 and RPMI8226 correspond to the tumour suppressor FUBP1. The D6 region showed conserved A-compartment across the samples specifically at the RPL5 and MTF2 loci while EVI5 and GFI1 showed switching from B-A across the differentiation stages. The D7 region, focused on TENT5C lies within an A-compartment across all samples except for KMS11, NBC=Naïve B-cell, MBC=Memory B-cell, GCBC=Germinal Center B-cell, PC=plasma cell.

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Landing Page: https://doi.org/10.1158/1078-0432.30709522
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DOI: https://doi.org/10.1158/1078-0432.30709522

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Title: Supplementary Figure S4 from Multiomic Mapping of Acquired Chromosome 1 Copy-Number and Structural Variants to Identify Therapeutic Vulnerabilities in Multiple Myeloma

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Authors: Eileen M. Boyle, Yubao Wang, Dylan Gagler, Louis Williams, Avital Tenenbaum, Ariel Siegel, Gaurav Varma, Jason Avigan, Monica Jinsi, David Kaminetzky, Arnaldo Arbini, Jill Corre, Benedetto Bruno, Faith E. Davies, Gareth J. Morgan

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