Supplementary Figure S4 from Multiomic Mapping of Acquired Chromosome 1 Copy-Number and Structural Variants to Identify Therapeutic Vulnerabilities in Multiple Myeloma

Exploring foci of: doi.org Supplementary Figure S4 from Multiomic Mapping of Acquired Chromosome 1 Copy-Number and Structural Variants to Identify Therapeutic Vulnerabilities in Multiple Myeloma November 2025 • Eileen M. Boyle, Yubao Wang, Dylan Gagler, Louis Williams, Avital Tenenbaum, Ariel Siegel, Gaurav Varma, Jason Avigan, Monica Jinsi, David Kaminetzky… &lt;p&gt;Chromatin state of varying deleted regions. There is a greater variability in terms of chromatin composition of the lost regions in comparision to the region of gain. The D1 region had identical an A-compartment percentage (56%) across all samples and reflected loss of significant subtelomeric region, including TNFRSF4. The D2 region was consistent across all samples (range 96-100% A-compartment) with the exception of KMS11 (47%), however this switch to a B-compartment occurred in a gene-sparse region. Th… Open Article Page

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