Mutant Cancers Article Swipe

View

Patricia J. Keller , Elizabeth J. Adams , Rentian Wu , Alexandre Côté , Shilpi Arora , Nico Cantone , Rosana Meyer , Jennifer A. Mertz , Victor Gehling , Jike Cui , Jacob I. Stuckey , Avinash Khanna , Feng Zhao , Zehua Chen , Ziyang Yu , Richard Cummings , Mohammed Taimi , Nehal J. Lakhani , Drew Rasco , Martin Gutierrez , Linda Duska , Michael Devitt , Ronda Rippley , Julian Levell , Jennifer Truong , Jing Wang , Kaiming Sun , Patrick Trojer ·

YOU? · · 2024 · Open Access · · DOI: https://doi.org/10.1158/0008-5472.26423915.v1

Tulmimetostat improves cisplatin responsiveness in chemotherapy-resistant bladder cancer cells.

Related Topics

Concepts

EZH2 Cisplatin Mutant Cancer research ARID1A Chemotherapy Medicine Internal medicine Biology Mutation Gene Epigenetics Genetics

Metadata

Type: preprint
Language: en
Landing Page: https://doi.org/10.1158/0008-5472.26423915.v1
OA Status: gold
Related Works: 10
OpenAlex ID: https://openalex.org/W4401205237

All OpenAlex metadata

Raw OpenAlex JSON

OpenAlex ID: https://openalex.org/W4401205237

Canonical identifier for this work in OpenAlex
DOI: https://doi.org/10.1158/0008-5472.26423915.v1

Digital Object Identifier
Title: Supplementary Figure S5 from Comprehensive Target Engagement by the EZH2 Inhibitor Tulmimetostat Allows for Targeting of <i>ARID1A</i> Mutant Cancers

Work title
Type: preprint

OpenAlex work type
Language: en

Primary language
Publication year: 2024

Year of publication
Publication date: 2024-08-01

Full publication date if available
Authors: Patricia J. Keller, Elizabeth J. Adams, Rentian Wu, Alexandre Côté, Shilpi Arora, Nico Cantone, Rosana Meyer, Jennifer A. Mertz, Victor Gehling, Jike Cui, Jacob I. Stuckey, Avinash Khanna, Feng Zhao, Zehua Chen, Ziyang Yu, Richard Cummings, Mohammed Taimi, Nehal J. Lakhani, Drew Rasco, Martin Gutierrez, Linda Duska, Michael Devitt, Ronda Rippley, Julian Levell, Jennifer Truong, Jing Wang, Kaiming Sun, Patrick Trojer

List of authors in order
Landing page: https://doi.org/10.1158/0008-5472.26423915.v1

Publisher landing page
Open access: Yes

Whether a free full text is available
OA status: gold

Open access status per OpenAlex
OA URL: https://doi.org/10.1158/0008-5472.26423915.v1

Direct OA link when available
Concepts: EZH2, Cisplatin, Mutant, Cancer research, ARID1A, Chemotherapy, Medicine, Internal medicine, Biology, Mutation, Gene, Epigenetics, Genetics

Top concepts (fields/topics) attached by OpenAlex
Cited by: 0

Total citation count in OpenAlex
Related works (count): 10

Other works algorithmically related by OpenAlex

Full payload

id	https://openalex.org/W4401205237
doi	https://doi.org/10.1158/0008-5472.26423915.v1
ids.doi	https://doi.org/10.1158/0008-5472.26423915.v1
ids.openalex	https://openalex.org/W4401205237
fwci	0.0
type	preprint
title	Supplementary Figure S5 from Comprehensive Target Engagement by the EZH2 Inhibitor Tulmimetostat Allows for Targeting of <i>ARID1A</i> Mutant Cancers
biblio.issue
biblio.volume
biblio.last_page
biblio.first_page
topics[0].id	https://openalex.org/T12820
topics[0].field.id	https://openalex.org/fields/13
topics[0].field.display_name	Biochemistry, Genetics and Molecular Biology
topics[0].score	0.987500011920929
topics[0].domain.id	https://openalex.org/domains/1
topics[0].domain.display_name	Life Sciences
topics[0].subfield.id	https://openalex.org/subfields/1312
topics[0].subfield.display_name	Molecular Biology
topics[0].display_name	Chromatin Remodeling and Cancer
topics[1].id	https://openalex.org/T12505
topics[1].field.id	https://openalex.org/fields/27
topics[1].field.display_name	Medicine
topics[1].score	0.9563000202178955
topics[1].domain.id	https://openalex.org/domains/4
topics[1].domain.display_name	Health Sciences
topics[1].subfield.id	https://openalex.org/subfields/2730
topics[1].subfield.display_name	Oncology
topics[1].display_name	Peptidase Inhibition and Analysis
topics[2].id	https://openalex.org/T13437
topics[2].field.id	https://openalex.org/fields/13
topics[2].field.display_name	Biochemistry, Genetics and Molecular Biology
topics[2].score	0.9541000127792358
topics[2].domain.id	https://openalex.org/domains/1
topics[2].domain.display_name	Life Sciences
topics[2].subfield.id	https://openalex.org/subfields/1312
topics[2].subfield.display_name	Molecular Biology
topics[2].display_name	Mechanisms of cancer metastasis
is_xpac	False
apc_list
apc_paid
concepts[0].id	https://openalex.org/C50171091
concepts[0].level	4
concepts[0].score	0.7663858532905579
concepts[0].wikidata	https://www.wikidata.org/wiki/Q17917770
concepts[0].display_name	EZH2
concepts[1].id	https://openalex.org/C2778239845
concepts[1].level	3
concepts[1].score	0.740480899810791
concepts[1].wikidata	https://www.wikidata.org/wiki/Q412415
concepts[1].display_name	Cisplatin
concepts[2].id	https://openalex.org/C143065580
concepts[2].level	3
concepts[2].score	0.6705126166343689
concepts[2].wikidata	https://www.wikidata.org/wiki/Q3285695
concepts[2].display_name	Mutant
concepts[3].id	https://openalex.org/C502942594
concepts[3].level	1
concepts[3].score	0.5856425762176514
concepts[3].wikidata	https://www.wikidata.org/wiki/Q3421914
concepts[3].display_name	Cancer research
concepts[4].id	https://openalex.org/C2781273526
concepts[4].level	4
concepts[4].score	0.4592888057231903
concepts[4].wikidata	https://www.wikidata.org/wiki/Q18032797
concepts[4].display_name	ARID1A
concepts[5].id	https://openalex.org/C2776694085
concepts[5].level	2
concepts[5].score	0.31704163551330566
concepts[5].wikidata	https://www.wikidata.org/wiki/Q974135
concepts[5].display_name	Chemotherapy
concepts[6].id	https://openalex.org/C71924100
concepts[6].level	0
concepts[6].score	0.3030586242675781
concepts[6].wikidata	https://www.wikidata.org/wiki/Q11190
concepts[6].display_name	Medicine
concepts[7].id	https://openalex.org/C126322002
concepts[7].level	1
concepts[7].score	0.2867259383201599
concepts[7].wikidata	https://www.wikidata.org/wiki/Q11180
concepts[7].display_name	Internal medicine
concepts[8].id	https://openalex.org/C86803240
concepts[8].level	0
concepts[8].score	0.2581166625022888
concepts[8].wikidata	https://www.wikidata.org/wiki/Q420
concepts[8].display_name	Biology
concepts[9].id	https://openalex.org/C501734568
concepts[9].level	3
concepts[9].score	0.18379512429237366
concepts[9].wikidata	https://www.wikidata.org/wiki/Q42918
concepts[9].display_name	Mutation
concepts[10].id	https://openalex.org/C104317684
concepts[10].level	2
concepts[10].score	0.17864978313446045
concepts[10].wikidata	https://www.wikidata.org/wiki/Q7187
concepts[10].display_name	Gene
concepts[11].id	https://openalex.org/C41091548
concepts[11].level	3
concepts[11].score	0.13202792406082153
concepts[11].wikidata	https://www.wikidata.org/wiki/Q26939
concepts[11].display_name	Epigenetics
concepts[12].id	https://openalex.org/C54355233
concepts[12].level	1
concepts[12].score	0.11593788862228394
concepts[12].wikidata	https://www.wikidata.org/wiki/Q7162
concepts[12].display_name	Genetics
keywords[0].id	https://openalex.org/keywords/ezh2
keywords[0].score	0.7663858532905579
keywords[0].display_name	EZH2
keywords[1].id	https://openalex.org/keywords/cisplatin
keywords[1].score	0.740480899810791
keywords[1].display_name	Cisplatin
keywords[2].id	https://openalex.org/keywords/mutant
keywords[2].score	0.6705126166343689
keywords[2].display_name	Mutant
keywords[3].id	https://openalex.org/keywords/cancer-research
keywords[3].score	0.5856425762176514
keywords[3].display_name	Cancer research
keywords[4].id	https://openalex.org/keywords/arid1a
keywords[4].score	0.4592888057231903
keywords[4].display_name	ARID1A
keywords[5].id	https://openalex.org/keywords/chemotherapy
keywords[5].score	0.31704163551330566
keywords[5].display_name	Chemotherapy
keywords[6].id	https://openalex.org/keywords/medicine
keywords[6].score	0.3030586242675781
keywords[6].display_name	Medicine
keywords[7].id	https://openalex.org/keywords/internal-medicine
keywords[7].score	0.2867259383201599
keywords[7].display_name	Internal medicine
keywords[8].id	https://openalex.org/keywords/biology
keywords[8].score	0.2581166625022888
keywords[8].display_name	Biology
keywords[9].id	https://openalex.org/keywords/mutation
keywords[9].score	0.18379512429237366
keywords[9].display_name	Mutation
keywords[10].id	https://openalex.org/keywords/gene
keywords[10].score	0.17864978313446045
keywords[10].display_name	Gene
keywords[11].id	https://openalex.org/keywords/epigenetics
keywords[11].score	0.13202792406082153
keywords[11].display_name	Epigenetics
keywords[12].id	https://openalex.org/keywords/genetics
keywords[12].score	0.11593788862228394
keywords[12].display_name	Genetics
language	en
locations[0].id	doi:10.1158/0008-5472.26423915.v1
locations[0].is_oa	True
locations[0].source
locations[0].license	cc-by
locations[0].pdf_url
locations[0].version	acceptedVersion
locations[0].raw_type	posted-content
locations[0].license_id	https://openalex.org/licenses/cc-by
locations[0].is_accepted	True
locations[0].is_published	False
locations[0].raw_source_name
locations[0].landing_page_url	https://doi.org/10.1158/0008-5472.26423915.v1
locations[1].id	pmh:oai:figshare.com:article/26423915
locations[1].is_oa	True
locations[1].source.id	https://openalex.org/S4306400572
locations[1].source.issn
locations[1].source.type	repository
locations[1].source.is_oa	False
locations[1].source.issn_l
locations[1].source.is_core	False
locations[1].source.is_in_doaj	False
locations[1].source.display_name	OPAL (Open@LaTrobe) (La Trobe University)
locations[1].source.host_organization	https://openalex.org/I196829312
locations[1].source.host_organization_name	La Trobe University
locations[1].source.host_organization_lineage	https://openalex.org/I196829312
locations[1].license	cc-by
locations[1].pdf_url
locations[1].version	submittedVersion
locations[1].raw_type	Text
locations[1].license_id	https://openalex.org/licenses/cc-by
locations[1].is_accepted	False
locations[1].is_published	False
locations[1].raw_source_name
locations[1].landing_page_url	https://figshare.com/articles/journal_contribution/Supplementary_Figure_S5_from_Comprehensive_Target_Engagement_by_the_EZH2_Inhibitor_Tulmimetostat_Allows_for_Targeting_of_i_ARID1A_i_Mutant_Cancers/26423915
indexed_in	crossref
authorships[0].author.id	https://openalex.org/A5023605713
authorships[0].author.orcid	https://orcid.org/0000-0002-7252-7843
authorships[0].author.display_name	Patricia J. Keller
authorships[0].author_position	first
authorships[0].raw_author_name	Patricia J. Keller
authorships[0].is_corresponding	False
authorships[1].author.id	https://openalex.org/A5103143974
authorships[1].author.orcid	https://orcid.org/0009-0008-0693-9955
authorships[1].author.display_name	Elizabeth J. Adams
authorships[1].author_position	middle
authorships[1].raw_author_name	Elizabeth J. Adams
authorships[1].is_corresponding	False
authorships[2].author.id	https://openalex.org/A5064347182
authorships[2].author.orcid	https://orcid.org/0000-0003-3862-6394
authorships[2].author.display_name	Rentian Wu
authorships[2].author_position	middle
authorships[2].raw_author_name	Rentian Wu
authorships[2].is_corresponding	False
authorships[3].author.id	https://openalex.org/A5085416763
authorships[3].author.orcid	https://orcid.org/0000-0002-0007-7492
authorships[3].author.display_name	Alexandre Côté
authorships[3].author_position	middle
authorships[3].raw_author_name	Alexandre Côté
authorships[3].is_corresponding	False
authorships[4].author.id	https://openalex.org/A5103101188
authorships[4].author.orcid	https://orcid.org/0000-0002-8918-6061
authorships[4].author.display_name	Shilpi Arora
authorships[4].author_position	middle
authorships[4].raw_author_name	Shilpi Arora
authorships[4].is_corresponding	False
authorships[5].author.id	https://openalex.org/A5071082430
authorships[5].author.orcid	https://orcid.org/0000-0001-9709-8830
authorships[5].author.display_name	Nico Cantone
authorships[5].author_position	middle
authorships[5].raw_author_name	Nico Cantone
authorships[5].is_corresponding	False
authorships[6].author.id	https://openalex.org/A5031505899
authorships[6].author.orcid	https://orcid.org/0009-0004-1211-0220
authorships[6].author.display_name	Rosana Meyer
authorships[6].author_position	middle
authorships[6].raw_author_name	Rosana Meyer
authorships[6].is_corresponding	False
authorships[7].author.id	https://openalex.org/A5078816311
authorships[7].author.orcid	https://orcid.org/0000-0002-4716-1077
authorships[7].author.display_name	Jennifer A. Mertz
authorships[7].author_position	middle
authorships[7].raw_author_name	Jennifer A. Mertz
authorships[7].is_corresponding	False
authorships[8].author.id	https://openalex.org/A5073237176
authorships[8].author.orcid	https://orcid.org/0000-0003-1741-7040
authorships[8].author.display_name	Victor Gehling
authorships[8].author_position	middle
authorships[8].raw_author_name	Victor Gehling
authorships[8].is_corresponding	False
authorships[9].author.id	https://openalex.org/A5022991992
authorships[9].author.orcid	https://orcid.org/0009-0007-9795-8950
authorships[9].author.display_name	Jike Cui
authorships[9].author_position	middle
authorships[9].raw_author_name	Jike Cui
authorships[9].is_corresponding	False
authorships[10].author.id	https://openalex.org/A5016485485
authorships[10].author.orcid	https://orcid.org/0009-0003-1389-5819
authorships[10].author.display_name	Jacob I. Stuckey
authorships[10].author_position	middle
authorships[10].raw_author_name	Jacob I. Stuckey
authorships[10].is_corresponding	False
authorships[11].author.id	https://openalex.org/A5001854130
authorships[11].author.orcid	https://orcid.org/0000-0003-0471-8573
authorships[11].author.display_name	Avinash Khanna
authorships[11].author_position	middle
authorships[11].raw_author_name	Avinash Khanna
authorships[11].is_corresponding	False
authorships[12].author.id	https://openalex.org/A5064728048
authorships[12].author.orcid	https://orcid.org/0009-0003-7826-9229
authorships[12].author.display_name	Feng Zhao
authorships[12].author_position	middle
authorships[12].raw_author_name	Feng Zhao
authorships[12].is_corresponding	False
authorships[13].author.id	https://openalex.org/A5006369073
authorships[13].author.orcid	https://orcid.org/0009-0002-2968-6379
authorships[13].author.display_name	Zehua Chen
authorships[13].author_position	middle
authorships[13].raw_author_name	Zehua Chen
authorships[13].is_corresponding	False
authorships[14].author.id	https://openalex.org/A5004328787
authorships[14].author.orcid	https://orcid.org/0009-0000-5297-3232
authorships[14].author.display_name	Ziyang Yu
authorships[14].author_position	middle
authorships[14].raw_author_name	Ziyang Yu
authorships[14].is_corresponding	False
authorships[15].author.id	https://openalex.org/A5056521805
authorships[15].author.orcid	https://orcid.org/0000-0002-8514-8287
authorships[15].author.display_name	Richard Cummings
authorships[15].author_position	middle
authorships[15].raw_author_name	Richard T. Cummings
authorships[15].is_corresponding	False
authorships[16].author.id	https://openalex.org/A5078987885
authorships[16].author.orcid	https://orcid.org/0009-0000-9549-4506
authorships[16].author.display_name	Mohammed Taimi
authorships[16].author_position	middle
authorships[16].raw_author_name	Mohammed Taimi
authorships[16].is_corresponding	False
authorships[17].author.id	https://openalex.org/A5003770647
authorships[17].author.orcid	https://orcid.org/0009-0005-6327-0176
authorships[17].author.display_name	Nehal J. Lakhani
authorships[17].author_position	middle
authorships[17].raw_author_name	Nehal J. Lakhani
authorships[17].is_corresponding	False
authorships[18].author.id	https://openalex.org/A5073134832
authorships[18].author.orcid	https://orcid.org/0009-0009-6619-2854
authorships[18].author.display_name	Drew Rasco
authorships[18].author_position	middle
authorships[18].raw_author_name	Drew Rasco
authorships[18].is_corresponding	False
authorships[19].author.id	https://openalex.org/A5022339242
authorships[19].author.orcid
authorships[19].author.display_name	Martin Gutierrez
authorships[19].author_position	middle
authorships[19].raw_author_name	Martin Gutierrez
authorships[19].is_corresponding	False
authorships[20].author.id	https://openalex.org/A5054372225
authorships[20].author.orcid	https://orcid.org/0000-0002-8878-4123
authorships[20].author.display_name	Linda Duska
authorships[20].author_position	middle
authorships[20].raw_author_name	Linda Duska
authorships[20].is_corresponding	False
authorships[21].author.id	https://openalex.org/A5040044206
authorships[21].author.orcid	https://orcid.org/0000-0001-7502-1584
authorships[21].author.display_name	Michael Devitt
authorships[21].author_position	middle
authorships[21].raw_author_name	Michael Devitt
authorships[21].is_corresponding	False
authorships[22].author.id	https://openalex.org/A5073524401
authorships[22].author.orcid	https://orcid.org/0009-0007-7558-8485
authorships[22].author.display_name	Ronda Rippley
authorships[22].author_position	middle
authorships[22].raw_author_name	Ronda Rippley
authorships[22].is_corresponding	False
authorships[23].author.id	https://openalex.org/A5069805829
authorships[23].author.orcid	https://orcid.org/0000-0002-6171-3819
authorships[23].author.display_name	Julian Levell
authorships[23].author_position	middle
authorships[23].raw_author_name	Julian Levell
authorships[23].is_corresponding	False
authorships[24].author.id	https://openalex.org/A5099011040
authorships[24].author.orcid	https://orcid.org/0000-0002-8161-3567
authorships[24].author.display_name	Jennifer Truong
authorships[24].author_position	middle
authorships[24].raw_author_name	Jennifer Truong
authorships[24].is_corresponding	False
authorships[25].author.id	https://openalex.org/A5103096994
authorships[25].author.orcid	https://orcid.org/0009-0006-4171-5397
authorships[25].author.display_name	Jing Wang
authorships[25].author_position	middle
authorships[25].raw_author_name	Jing Wang
authorships[25].is_corresponding	False
authorships[26].author.id	https://openalex.org/A5002236657
authorships[26].author.orcid	https://orcid.org/0000-0001-5376-1266
authorships[26].author.display_name	Kaiming Sun
authorships[26].author_position	middle
authorships[26].raw_author_name	Kaiming Sun
authorships[26].is_corresponding	False
authorships[27].author.id	https://openalex.org/A5013707401
authorships[27].author.orcid	https://orcid.org/0000-0001-9969-9154
authorships[27].author.display_name	Patrick Trojer
authorships[27].author_position	last
authorships[27].raw_author_name	Patrick Trojer
authorships[27].is_corresponding	False
has_content.pdf	False
has_content.grobid_xml	False
is_paratext	False
open_access.is_oa	True
open_access.oa_url	https://doi.org/10.1158/0008-5472.26423915.v1
open_access.oa_status	gold
open_access.any_repository_has_fulltext	False
created_date	2025-10-10T00:00:00
display_name	Supplementary Figure S5 from Comprehensive Target Engagement by the EZH2 Inhibitor Tulmimetostat Allows for Targeting of <i>ARID1A</i> Mutant Cancers
has_fulltext	False
is_retracted	False
updated_date	2025-11-06T03:46:38.306776
primary_topic.id	https://openalex.org/T12820
primary_topic.field.id	https://openalex.org/fields/13
primary_topic.field.display_name	Biochemistry, Genetics and Molecular Biology
primary_topic.score	0.987500011920929
primary_topic.domain.id	https://openalex.org/domains/1
primary_topic.domain.display_name	Life Sciences
primary_topic.subfield.id	https://openalex.org/subfields/1312
primary_topic.subfield.display_name	Molecular Biology
primary_topic.display_name	Chromatin Remodeling and Cancer
related_works	https://openalex.org/W2808297012, https://openalex.org/W2797161045, https://openalex.org/W2048122601, https://openalex.org/W2402801680, https://openalex.org/W3049101641, https://openalex.org/W3166420098, https://openalex.org/W2399487273, https://openalex.org/W3119406774, https://openalex.org/W3023592350, https://openalex.org/W2767008663
cited_by_count	0
locations_count	2
best_oa_location.id	doi:10.1158/0008-5472.26423915.v1
best_oa_location.is_oa	True
best_oa_location.source
best_oa_location.license	cc-by
best_oa_location.pdf_url
best_oa_location.version	acceptedVersion
best_oa_location.raw_type	posted-content
best_oa_location.license_id	https://openalex.org/licenses/cc-by
best_oa_location.is_accepted	True
best_oa_location.is_published	False
best_oa_location.raw_source_name
best_oa_location.landing_page_url	https://doi.org/10.1158/0008-5472.26423915.v1
primary_location.id	doi:10.1158/0008-5472.26423915.v1
primary_location.is_oa	True
primary_location.source
primary_location.license	cc-by
primary_location.pdf_url
primary_location.version	acceptedVersion
primary_location.raw_type	posted-content
primary_location.license_id	https://openalex.org/licenses/cc-by
primary_location.is_accepted	True
primary_location.is_published	False
primary_location.raw_source_name
primary_location.landing_page_url	https://doi.org/10.1158/0008-5472.26423915.v1
publication_date	2024-08-01
publication_year	2024
referenced_works_count	0
abstract_inverted_index.in	4
abstract_inverted_index.cancer	7
abstract_inverted_index.bladder	6
abstract_inverted_index.improves	1
abstract_inverted_index.cisplatin	2
abstract_inverted_index.responsiveness	3
abstract_inverted_index.cells.</p>	8
abstract_inverted_index.<p>Tulmimetostat	0
abstract_inverted_index.chemotherapy-resistant	5
cited_by_percentile_year
countries_distinct_count	0
institutions_distinct_count	28
citation_normalized_percentile.value	0.1409443
citation_normalized_percentile.is_in_top_1_percent	False
citation_normalized_percentile.is_in_top_10_percent	False