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Olaf Klingbeil , Damianos Skopelitis , Claudia Tonelli , Toyoki Yoshimoto , Aktan Alpsoy , Maria C. Panepinto , Francesca Minicozzi , Joseph R. Merrill , Amanda M. Cafiero , Disha Aggarwal , Suzanne Russo , Taehoon Ha , Osama E. Demerdash , Tse-Luen Wee , David L. Spector , Scott K. Lyons , David A. Tuveson , Paolo Cifani , Christopher R. Vakoc ·

YOU? · · 2024 · Open Access · · DOI: https://doi.org/10.1158/2159-8290.27938732

A, IP–western blot analysis evaluating the interaction between 14-3-3e and YAPWT and YAP5D mutants or TAZWT and TAZ4D mutants in HEK-293T cells. Aspartate mutant reversion to wild-type S/T is indicated. Data are representative of two independent experiments. B, mRNA expression log2 fold-change of YAP/TAZ target genes (n=78 genes significantly downregulated upon YAP/TAZdKO and upregulated upon YAPWT expression) following YAP mutant overexpression compared to Ctrl in RH-30 cells. n=2 C, Rescue experiment of MARK2+3dKO following lentiviral YAP mutant overexpression in RH-30 cells. Data shown are the mean ± SD of %GFP+ (normalized to day 3 after infection). n=3. P values are calculated using a mixed effects model (considering the interaction of experimental groups over time) compared to Ctrl group and corrected with Bonferroni-Holm (BH). Data are an extension of Figure 4E. D, Western blot analysis in RH-30 cells following cDNA overexpression of YAP mutants. E,F, Representative immunofluorescence (IF) images of HA-YAP or HA-TAZ mutants, DAPI, and alpha-tubulin following lentiviral overexpression of indicated mutants in HEK-293T cells. scale bar: 30µm.

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Kinase Cancer research Medicine Chemistry Biochemistry

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Type: preprint
Language: en
Landing Page: https://doi.org/10.1158/2159-8290.27938732
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Title: Supplementary Figure S7 from MARK2/MARK3 Kinases Are Catalytic Codependencies of YAP/TAZ in Human Cancer

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Publication year: 2024

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Authors: Olaf Klingbeil, Damianos Skopelitis, Claudia Tonelli, Toyoki Yoshimoto, Aktan Alpsoy, Maria C. Panepinto, Francesca Minicozzi, Joseph R. Merrill, Amanda M. Cafiero, Disha Aggarwal, Suzanne Russo, Taehoon Ha, Osama E. Demerdash, Tse-Luen Wee, David L. Spector, Scott K. Lyons, David A. Tuveson, Paolo Cifani, Christopher R. Vakoc

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Concepts: Kinase, Cancer research, Medicine, Chemistry, Biochemistry

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