Supplementary Figure S8 from MARK2/MARK3 Kinases Are Catalytic Codependencies of YAP/TAZ in Human Cancer Article Swipe
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· 2024
· Open Access
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· DOI: https://doi.org/10.1158/2159-8290.27938729
A, Rescue experiment of MARK2+3dKO in Cas9+ YAPC cells following knockout of indicated genes. Data shown are the mean ± SD of %GFP+ (normalized to day 3 after infection). n=3-6. P values are calculated using a mixed effects model (considering the interaction of experimental groups over time) compared to Ctrl group and corrected with Bonferroni-Holm (BH). B, Western blot analysis of YAPC cells. C, Normalized relative luminescence units (RLU) from CellTiter-Glo viability measurements of Cas9+ YAPC-MARK2+3dKO + MARK2M129G cells following 5 days of combinational treatment of 1NM-PP1 and either +DMSO (0.1%), +500nM MST1/2 inhibitor (XMU-MP-1) or + 5µM LATS1/2 inhibitor (Lats-IN-1). Data are shown as mean ± SD. n=9 measurements from three biological replicates performed in triplicate. Four-parameter dose-response curves were plotted. D,E Competition-based fitness assays for Ctrl and knockout of essential gene CDK1 corresponding to rescue experiment shown in Fig. 5A, 5E. Data shown are the mean ± SD of %GFP+ (normalized to day 3 after infection). n=3-6.
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- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1158/2159-8290.27938729
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https://openalex.org/W4404933603Canonical identifier for this work in OpenAlex
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https://doi.org/10.1158/2159-8290.27938729Digital Object Identifier
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Supplementary Figure S8 from MARK2/MARK3 Kinases Are Catalytic Codependencies of YAP/TAZ in Human CancerWork title
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preprintOpenAlex work type
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enPrimary language
- Publication year
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2024Year of publication
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2024-12-02Full publication date if available
- Authors
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Olaf Klingbeil, Damianos Skopelitis, Claudia Tonelli, Toyoki Yoshimoto, Aktan Alpsoy, Maria C. Panepinto, Francesca Minicozzi, Joseph R. Merrill, Amanda M. Cafiero, Disha Aggarwal, Suzanne Russo, Taehoon Ha, Osama E. Demerdash, Tse-Luen Wee, David L. Spector, Scott K. Lyons, David A. Tuveson, Paolo Cifani, Christopher R. VakocList of authors in order
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https://doi.org/10.1158/2159-8290.27938729Publisher landing page
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https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_S8_from_MARK2_MARK3_Kinases_Are_Catalytic_Codependencies_of_YAP_TAZ_in_Human_Cancer/27938729/1/files/50907185.pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_S8_from_MARK2_MARK3_Kinases_Are_Catalytic_Codependencies_of_YAP_TAZ_in_Human_Cancer/27938729/1/files/50907185.pdfDirect OA link when available
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Kinase, Cyclin-dependent kinase 1, Molecular biology, Apoptosis, Gene knockout, Andrology, Gene, Chemistry, Biology, Cell cycle, Medicine, GeneticsTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.over | 45 |
| abstract_inverted_index.were | 120 |
| abstract_inverted_index.with | 53 |
| abstract_inverted_index.%GFP+ | 22, 151 |
| abstract_inverted_index.(BH). | 55 |
| abstract_inverted_index.(RLU) | 68 |
| abstract_inverted_index.+DMSO | 89 |
| abstract_inverted_index.Cas9+ | 6, 74 |
| abstract_inverted_index.after | 27, 156 |
| abstract_inverted_index.cells | 8, 78 |
| abstract_inverted_index.group | 50 |
| abstract_inverted_index.mixed | 36 |
| abstract_inverted_index.model | 38 |
| abstract_inverted_index.shown | 15, 103, 138, 144 |
| abstract_inverted_index.three | 111 |
| abstract_inverted_index.time) | 46 |
| abstract_inverted_index.units | 67 |
| abstract_inverted_index.using | 34 |
| abstract_inverted_index.+500nM | 91 |
| abstract_inverted_index.MST1/2 | 92 |
| abstract_inverted_index.Rescue | 1 |
| abstract_inverted_index.assays | 125 |
| abstract_inverted_index.cells. | 62 |
| abstract_inverted_index.curves | 119 |
| abstract_inverted_index.either | 88 |
| abstract_inverted_index.genes. | 13 |
| abstract_inverted_index.groups | 44 |
| abstract_inverted_index.n=3-6. | 29 |
| abstract_inverted_index.rescue | 136 |
| abstract_inverted_index.values | 31 |
| abstract_inverted_index.(0.1%), | 90 |
| abstract_inverted_index.1NM-PP1 | 86 |
| abstract_inverted_index.LATS1/2 | 98 |
| abstract_inverted_index.Western | 57 |
| abstract_inverted_index.effects | 37 |
| abstract_inverted_index.fitness | 124 |
| abstract_inverted_index.analysis | 59 |
| abstract_inverted_index.compared | 47 |
| abstract_inverted_index.knockout | 10, 129 |
| abstract_inverted_index.plotted. | 121 |
| abstract_inverted_index.relative | 65 |
| abstract_inverted_index.corrected | 52 |
| abstract_inverted_index.essential | 131 |
| abstract_inverted_index.following | 9, 79 |
| abstract_inverted_index.indicated | 12 |
| abstract_inverted_index.inhibitor | 93, 99 |
| abstract_inverted_index.performed | 114 |
| abstract_inverted_index.treatment | 84 |
| abstract_inverted_index.viability | 71 |
| abstract_inverted_index.(XMU-MP-1) | 94 |
| abstract_inverted_index.MARK2+3dKO | 4 |
| abstract_inverted_index.MARK2M129G | 77 |
| abstract_inverted_index.Normalized | 64 |
| abstract_inverted_index.biological | 112 |
| abstract_inverted_index.calculated | 33 |
| abstract_inverted_index.experiment | 2, 137 |
| abstract_inverted_index.replicates | 113 |
| abstract_inverted_index.<p>A, | 0 |
| abstract_inverted_index.(normalized | 23, 152 |
| abstract_inverted_index.infection). | 28, 157 |
| abstract_inverted_index.interaction | 41 |
| abstract_inverted_index.triplicate. | 116 |
| abstract_inverted_index.(Lats-IN-1). | 100 |
| abstract_inverted_index.(considering | 39 |
| abstract_inverted_index.experimental | 43 |
| abstract_inverted_index.luminescence | 66 |
| abstract_inverted_index.measurements | 72, 109 |
| abstract_inverted_index.CellTiter-Glo | 70 |
| abstract_inverted_index.combinational | 83 |
| abstract_inverted_index.corresponding | 134 |
| abstract_inverted_index.dose-response | 118 |
| abstract_inverted_index.Four-parameter | 117 |
| abstract_inverted_index.Bonferroni-Holm | 54 |
| abstract_inverted_index.YAPC-MARK2+3dKO | 75 |
| abstract_inverted_index.n=3-6.</p> | 158 |
| abstract_inverted_index.Competition-based | 123 |
| cited_by_percentile_year | |
| countries_distinct_count | 0 |
| institutions_distinct_count | 19 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.6200000047683716 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.37672644 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |